Sazine DS 1000mg Tablet is a medicine used to treat various inflammatory conditions of the joints (rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis), skin (psoriasis), and bowel (ulcerative colitis, Crohn’s disease).

Sazine DS 1000mg Tablet is to be taken with food. This will help you prevent an upset stomach. You should take it regularly and at the same time each day to get the maximum benefit from it. Keep taking it as recommended by your doctor and complete the dose even if you feel better. Taking it with plenty of water can help you avoid kidney problems such as kidney stones.

Using this medicine may cause some common side effects such as nausea, headache, loss of appetite, vomiting, diarrhea, and gastrointestinal discomfort. You should consult with your doctor if any of these side effects do resolve with time or get worse. Your doctor may help with ways to reduce or prevent these symptoms.

To make sure the medicine is safe for you, before taking this medicine, let your doctor know if you have any problem with your heart, kidneys, or liver. Also, tell your doctor about all the other medicines you are taking. Your doctor may recommend regular blood tests to check your kidney and liver functions, and blood components. Pregnant and breastfeeding mothers should consult with their doctors before taking the medicine.

Uses of Sazine Tablet

Ulcerative colitis
Crohn’s disease
Systemic lupus erythematosus (SLE)
Wilson's disease
Ankylosing spondylitis
Psoriatic arthritis
Rheumatoid arthritis
Type 2 diabetes mellitus

Side effects of Sazine Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Sazine

Diarrhea
Gastrointestinal discomfort
Headache
Loss of appetite
Nausea
Oligospermia (low sperm count)
Vomiting

How to use Sazine Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Sazine DS 1000mg Tablet is to be taken with food.

How Sazine Tablet works

Sazine DS 1000mg Tablet is a Disease Modifying Anti-Rheumatoid Drug (DMARD). It works by suppressing the overactivity of the immune system in autoimmune diseases and blocks the chemical messengers that cause inflammation (swelling).

Safety advice

Alcohol

UNSAFE

It is unsafe to consume alcohol with Sazine DS 1000mg Tablet.

Pregnancy

SAFE IF PRESCRIBED

Sazine DS 1000mg Tablet is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.

Breast feeding

CONSULT YOUR DOCTOR

Sazine DS 1000mg Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

Driving

SAFE

Sazine DS 1000mg Tablet does not usually affect your ability to drive.

Kidney

CAUTION

Sazine DS 1000mg Tablet should be used with caution in patients with kidney disease. Dose adjustment of Sazine DS 1000mg Tablet may be needed. Please consult your doctor.
Regular monitoring of kidney function tests is advisable while you are taking this medicine.

Liver

UNSAFE

Sazine DS 1000mg Tablet is probably unsafe to use in patients with liver disease and should be avoided. Please consult your doctor.

What if you forget to take Sazine Tablet?

If you miss a dose of Sazine DS 1000mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.

Sazine DS 1000mg Tablet

₹14.9/Tablet

Sazo 1000mg Tablet

Wallace Pharmaceuticals Pvt Ltd

₹18.4/tablet

23% costlier

SFZ DS Tablet

TBG pharma ltd

₹14.5/tablet

3% cheaper

Saaz-DS Tablet

Ipca Laboratories Ltd

₹17.1/tablet

15% costlier

Sulseas DS Tablet

Overseas Healthcare Pvt Ltd

₹16.67/tablet

12% costlier

Salazar DS Tablet

Zydus Cadila

₹18.6/tablet

25% costlier

View all substitutes

Quick tips

Take it with food to avoid an upset stomach.
It may take 6-8 weeks for Sazine DS 1000mg Tablet to work. Keep taking it as prescribed.
Drink plenty of fluids while taking Sazine DS 1000mg Tablet in order to avoid kidney problems such as kidney stones.
It may cause a deficiency of folic acid. Take the supplements as suggested by the doctor.
Do not take Sazine DS 1000mg Tablet if you are allergic to sulfa drugs or aspirin.
It may discolour your skin, urine, saliva and tears an orange/yellow colour. This is normal and not harmful.
Regular blood tests to monitor your liver function, kidney function, and the levels of your blood components are required while taking this medicine.
Do not stop taking the medication suddenly without talking to your doctor.

Fact Box

Chemical Class

Aminosalicylic Acids Derivative

Habit Forming

Therapeutic Class

GASTRO INTESTINAL

Action Class

Non-Biologic DMARDs (Disease Modifying Anti-Rheumatoid Drugs)

Interaction with drugs

Taking Sazine with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Leflunomide (Oral Route) Moderate

Leflunomide may raise blood levels of Sulfasalazine. watch out for symptoms of Sulfasalazine side effects such as diarrhea, headache, loss of appetite, nausea or vomiting and cons... More

Clozapine (Oral Route) Moderate

Concurrent use may increase the risk of low blood cell counts. Your doctor may monitor your blood cell count and adjust the doses as per the observations.

Digoxin (Oral Route) Moderate

Sulfasalazine may reduce blood levels of Digoxin. Your doctor may monitor the effects of Digoxin along with your overall treatment and adjust the doses as per the observations.

Cholestyramine (Oral Route) Moderate

Sulfasalazine may increase the effect of Cholestyramine. To take Sulfasalazine, ensure a gap of 1 hour before and 6 hours after taking Cholestyramine.

Azathioprine (Oral Route) Moderate

Concurrent use may increase the risk of harmful effects on the blood, such as a decrease in blood cell counts, etc. If concurrent use is essential, your doctor may monitor blood c... More

View all drug interactions

Patient concerns

Suffering from type 2 diabetes rheumatoid arthritis , asthma which medicine should I use

Dr. Jagruti Mahendra Parikh

Diabetology

Most of the diabetic drugs can be given in Rheumatoid arthritis and asthma patients however however steroids treatments is given many times in asthma and Rhumatoid arthritis should be given with very caution in diabetic patients if indicatedMost suitable some times are insulin injections

I am looking for SLE systemic lupus erythematosus treatment. Do we have a cure in Ayurveda? If yes, old suggest a way out.

Dr. Deepak Kumar Soni

Ayurveda

Hi Kindly consult to any Ayurvedic Panchkarma center Ayurvedic Panchkarma will give you best result

Is there any permanent cure for rheumatoid arthritis doctor?

Vipul Aggarwal

The disease can be controlled with medicines and regular exercises it is an autoimmune disease and there will always be waxing and waning phenomena sometimes the disease process will be very much controlled but it can get aggravated no one can actually predict the cause of the disease It's always better to consult a remark largest as they deal with that betterLet me know if I can help you in any other way

FAQs

Is Sazine DS 1000mg Tablet a steroid or a painkiller?

Sazine DS 1000mg Tablet is neither a steroid nor a painkiller. It is an anti-inflammatory medicine. It is used to treat and manage ulcerative colitis and Crohn's disease in which the intestines become inflamed (swelling of intestines). It is also used to treat rheumatoid arthritis (painful joint disease).

What is Sazine DS 1000mg Tablet and what is it used for?

Sazine DS 1000mg Tablet belongs to a group of medicines called aminosalicylates. It is an anti-inflammatory disease and is used to treat bowel inflammation, diarrhea (stool frequency), rectal bleeding, and abdominal pain in patients with ulcerative colitis and Crohn’s disease. In rheumatoid arthritis, it helps prevent damage to the joints and works slowly to reduce swelling and stiffness in your joints.

I have been prescribed Sazine DS 1000mg Tablet for rheumatoid arthritis. When can I expect the pain in joints to be better?

Sazine DS 1000mg Tablet does not work right away. It takes about 6 to 12 weeks to deliver the full effect.You may start feeling better in 4 weeks after starting Sazine DS 1000mg Tablet, but it can vary from person to person and some of the patients may notice improvement after 3 months. Consumption of medicine should not be stopped without consulting your doctor.

For how long do I need to take Sazine DS 1000mg Tablet?

If you are able to tolerate Sazine DS 1000mg Tablet which means the side effects do not bother you, then you have to continue Sazine DS 1000mg Tablet till the disease remains in remission. It is better to take Sazine DS 1000mg Tablet for the prescribed period.

Does the use of Sazine DS 1000mg Tablet for the treatment of arthritis affect the kidney function?

Though it is uncommon, Sazine DS 1000mg Tablet may affect your kidney function. Therefore, it is important that your kidney function remains normal before you start taking Sazine DS 1000mg Tablet. If during treatment with Sazine DS 1000mg Tablet your kidney functions become abnormal, you should consult your doctor.

Do I need to get any blood tests done while on Sazine DS 1000mg Tablet therapy?

Your doctor will advise you blood tests to check your blood cell counts and your kidney function before starting your treatment and regularly during treatment. The tests should also be done to measure substances produced by your liver known as enzymes (liver function tests) and urine for protein and blood before you start treatment and at regular intervals.

Can Sazine DS 1000mg Tablet affect my fertility?

Decreased sperm count and infertility have been reported in some males. These may disappear once Sazine DS 1000mg Tablet is discontinued.

Can I take azathioprine along with Sazine DS 1000mg Tablet?

You should avoid using Sazine DS 1000mg Tablet with azathioprine since there are chances of decrease in blood cell count, which can be a serious side effect.

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Disclaimer:

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

Furst DE, Ulrich RW, Varkey-Altamirano C. Nonsteroidal Anti-Inflammatory Drugs, Disease Modifying Antirheumatic Drugs, Nonopioids Analgesics, & Drugs Used in Gout. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 632-33.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1295-97.
Sulfasalazine. Sandwich, Kent: Pfizer Limited; 2010 [revised Feb. 2014]. [Accessed 23 Jan. 2019] (online) Avaialble from:
Sulfasalazine. Uppsala, Sweden: Recipharm, Uppsala; 2018. [Accessed 18 Jun. 2019] (online) Available from:
Sulfasalazine. New York, New York: Pharmacia & Upjohn Co.; 2014. [Accessed 18 Jun. 2019] (online) Available from:
Oxford Radcliffe Hospitals: NHS Trust. Sulfasalazine. [Accessed 18 Jun. 2018] (online) Available from:
Chaves RG, Lamounier JA. Breastfeeding and maternal medications. J Pediatr (Rio J). 2004;80(5 Suppl):S189-S198. [Accessed 02 Apr. 2019] (online) Available from:
Choi J, Fenando A. Sulfasalazine. [Updated 2022 Nov 11]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023. [Accessed 06 Aug. 2023]. (online) Available from:
National Health Service. Sulfasalazine. [Accessed 06 Aug. 2023]. (online) Available from:
Versus Arthritis. Sulfasalazine [Information Booklet]. [Accessed 06 Aug. 2023]. (online) Available from:

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