Erythrocyte Sedimentation Rate
What is ESR?
Erythrocyte Sedimentation Rate (ESR) Test, also known as sedimentation rate test or sed rate test is a blood test which can detect inflammatory activity in the body. ESR test doesn’t diagnose one specific condition. Instead, it helps to diagnose or monitor the progress of an inflammatory disease.
Why is ESR done?
To detect any inflammation in the body which may be caused due to conditions such as infections, cancers, and autoimmune diseases
To monitor the progress of inflammatory diseases
To evaluate the response to treatment of inflammatory diseases
What does ESR Measure?
The ESR test measures the rate at which red blood cells (erythrocytes) settle (sediment) at the bottom of a tube that contains a blood sample in one hour. The test result is expressed in millimeters per hour (mm/hr).
In the presence of inflammation, certain proteins mainly fibrinogen increase in blood. This high proportion of fibrinogen in the blood causes the red blood cells to form a stack (rouleaux formation) which settle quickly due to their high density.
The ESR test is a non-specific measure of inflammation. An ESR can be affected by conditions other than inflammation also. Although a high ESR can detect the presence of inflammation, it cannot provide any information regarding the cause and site of inflammation. Hence, an ESR test is done along with other tests.
Interpreting ESR results
The normal reference range for Erythrocyte Sedimentation Rate (ESR) is:
0-15 millimetres per hour (mm/hr), or 0-20 mm/hr for men older than 50
0-20 mm/hr, or 0-30 mm/hr for women older than 50
High ESR can be seen in:
Inflammatory disease such as Arthritis (Inflammation of joints), vasculitis (Inflammation of blood vessels)
Infection, such as pneumonia, pelvic inflammatory disease, appendicitis, skin infection, bone infection, heart valve infection
Autoimmune diseases, such as systemic lupus erythematosus or rheumatoid arthritis
Chronic kidney disease
Cancer, such as lymphoma or multiple myeloma
Low ESR can be seen in:
Congestive heart failure
Sickle cell disease
Severe liver disease