Treatment Of Rheumatoid Arthritis
Rheumatoid arthritis has no cure. However, an early diagnosis can help in selecting a treatment to keep the symptoms under control. Some medications, such as disease-modifying antirheumatic drugs (DMARDs), work in slowing down the progression of the disease and saving the joints from damage.
There are three methods of treating rheumatoid arthritis related pain and symptoms:
A. Medications
These are given depending upon the intensity of the symptoms and the progression of the disease.
1. NSAIDs: Nonsteroidal anti-inflammatory drugs (NSAIDs) are prescribed for reducing pain and inflammation. NSAIDs, like i
buprofen, are available as an over the counter drug, but for stronger NSAIDs, a doctor’s prescription is needed.
2. DMARDs: Disease-modifying antirheumatic drugs (DMARDs) slow down the progression of this disease. This action helps save the joints and tissues from damage and disability.
- Methotrexate: It is an immunosuppressant. It slows the activity of the body’s immune system and reduces pain, swelling, and stiffness.
- Leflunomide: It blocks the chemical messengers that cause inflammation and swelling.
- Hydroxychloroquine: It eases the progression of the disease and reduces pain, swelling, and redness.
- Sulfasalazine: It suppresses the overactivity of the immune system and blocks the chemical messengers that cause inflammation.
3. Steroids: Corticosteroids reduce inflammation and damage to the joints and provide relief from pain. These drugs have specific side effects, such as weight gain, diabetes, and thinning of the bones. Therefore, they are prescribed for a short duration and the dose is decreased gradually.
Prednisone is one such corticosteroid that is prescribed to patients with rheumatoid arthritis.
4. Biological DMRADs: These are some of the latest DMARDs that are prescribed for swelling and redness. These are also known as biologic response modifiers. They block the chemical messengers that cause inflammation and give relief from swelling and redness. This category includes drugs like:
- Rituximab: This drug works by targeting the unwanted activity of immune cells (B cells) in rheumatoid arthritis.
- Abatacept: It blocks the action of certain chemical messengers that are responsible for inflammation, swelling, and redness associated with certain joint diseases.
- Tocilizumab: This is an anti interleukin-6 (IL-6) medication. IL-6 plays a key role in driving the inflammation that is responsible for joint destruction in rheumatoid arthritis.
- Anakinra: Interleukin-1(IL-1) is another important chemical messenger responsible for the development of RA. This drug works by blocking interleukin-1.
5. Anti-TNF drugs: Tumor necrosis factor (TNF) is a cytokine involved in systemic inflammation which plays a major role in the pathogenesis of RA. Some anti-TNF drugs which can be used in this condition are:
6. Targeted synthetic DMARDs: If the conventional DMARDs and the biological agents do not work, then targeted synthetic DMARDs are prescribed. Take these as per the doctor’s prescription to notice their effect. Doctors can also advise regular blood tests to monitor the liver, kidneys, and blood count. Examples of these drugs include:
B. Therapy
Physical or occupational therapy helps improve flexibility and eases joint pain. A therapist may teach ways to simplify tasks and to reduce mental and physical strain and stress. They may also guide in selecting gadgets that don’t strain the painful joints.
C. Surgery
It is advised when medications and therapy fail to slow the damage. It improves the functioning of joints and restores one’s ability to lead a productive life. A rheumatologist will advise some of the following procedures:
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Tendon repair: This consists of repairing the tendons around the joints.
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Synovectomy: It’s a surgery to remove the inflamed lining of the joints.
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Joint fusion (arthrodesis): Fusing of two or more bones in a joint to get relief from pain.
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Total joint replacement surgery: It consists of removing the damaged parts of the joint and replacing them with a metallic or plastic prosthesis.