HLA B27 (Human Leukocyte Antigen B27) - PCR

Human Leukocyte Antigens (HLAs) genes play a crucial role in the immune system, and the HLA B27 variant is associated with certain autoimmune conditions, especially a group of joint-related conditions known as seronegative spondyloarthropathies. These include ankylosing spondylitis, reactive arthritis, psoriatic arthritis, and juvenile idiopathic arthritis.

This test uses a method called PCR (polymerase chain reaction), which is more accurate and sensitive than other methods like flow cytometry. It helps doctors detect the HLA-B27 gene, assess the risk, and monitor the condition if symptoms are already present.

The doctor may suggest an HLA B27 (Human Leukocyte Antigen B27) - PCR test if there are signs and symptoms such as chronic back pain, joint pain, stiffness, or inflammation in the eyes, urethra, and joints, or have a family history of autoimmune conditions. The HLA B27 test is also used to match donated tissue to the tissue of the organ transplant recipient.

Usually, no special preparation is needed for this test. Eat and drink as per the daily routine. Also, inform the doctor about any medications being taken, as some medications may influence the test results if taken before this test.

Test result ranges may vary slightly across laboratories. Talk to your doctor to understand what the result means. Based on the findings, they may recommend lifestyle changes or medications to manage your health.