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ASCA - IgG antibody

ASCA - IgG antibody

Also referred as
Anti-Saccharomyces Cerevisiae Antibody IgG Test
Crohn's Disease Antibody Test
IgG Antibodies to Saccharomyces Cerevisiae Test
For men & women
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The ASCA - IgG antibody test is a blood test that detects IgG antibodies against Saccharomyces cerevisiae, a type of yeast present in the digestive tract. This test helps differentiate between inflammatory bowel diseases (IBD), particularly Crohn’s disease and ulcerative colitis.

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Understanding ASCA - IgG antibody

Saccharomyces cerevisiae is a normally harmless yeast found in the body and the environment. In some people, however, the immune system reacts by producing antibodies against it. These antibodies, known as anti-Saccharomyces cerevisiae antibodies (ASCA), are commonly linked with Crohn’s disease. Detecting ASCA-IgG in the blood helps differentiate Crohn’s disease from ulcerative colitis. While both conditions fall under the category of IBD, they affect different regions of the gastrointestinal tract and often require distinct treatment approaches.

The ASCA - IgG antibody test is recommended for individuals showing gastrointestinal symptoms such as persistent diarrhea, abdominal pain, weight loss, or rectal bleeding, especially when the clinical features do not clearly point towards either ulcerative colitis or Crohn’s disease. It is also valuable in cases with atypical or overlapping IBD symptoms where additional diagnostic information is needed. By identifying elevated ASCA-IgG levels, clinicians can tailor treatment more precisely to the patient’s condition.

No special preparation is needed for getting the ASCA - IgG antibody test done. However, be sure to inform the doctor about any medications or supplements being taken, as they may affect the test results. 

Lab test results may vary across different laboratories. Abnormal test results require expert interpretation. Therefore, never try to self-medicate based solely on these results. Always consult a doctor for a proper understanding of the test resul

Please note: This is an outsourced test. The sample for this test is collected by TATA 1MG and processed at a NABL accredited partnered lab.

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What does ASCA - IgG antibody measure?

The ASCA - IgG antibody test detects the presence of IgG antibodies produced by the immune system in response to Saccharomyces cerevisiae. These antibodies are usually present at very low levels in healthy individuals. Elevated IgG antibody levels suggest an abnormal immune reaction to yeast antigens, which is strongly associated with Crohn’s disease. While a positive result does not confirm the disease on its own, it provides supportive evidence when correlated with clinical signs and other laboratory tests. This test does not diagnose ulcerative colitis but can help differentiate between Crohn’s disease and ulcerative colitis, as ASCA positivity is far more common in Crohn’s disease.

FAQs related to ASCA - IgG antibody

The ASCA - IgG antibody test is a blood test that detects antibodies against Saccharomyces cerevisiae, a yeast commonly present in the digestive tract. It is mainly used to help differentiate between Crohn’s disease and ulcerative colitis, the two primary types of inflammatory bowel disease (IBD).
This test is recommended for individuals showing symptoms of IBD, such as persistent diarrhea, abdominal pain, weight loss, or rectal bleeding. It is especially useful when symptoms are unclear or when there is overlap between Crohn’s disease and ulcerative colitis, and a more precise diagnosis is needed to guide treatment.
The ASCA test is a simple blood test. A small blood sample is drawn from a vein in the arm and analyzed in the laboratory for the presence of ASCA antibodies.
A positive ASCA test indicates a higher likelihood of Crohn’s disease. However, results should not be interpreted in isolation and must be considered alongside clinical evaluation, colonoscopy, biopsy, and other diagnostic tests.
A negative result does not completely rule out inflammatory bowel disease but may be more consistent with ulcerative colitis or other gastrointestinal conditions. Doctors often combine this test with other findings to reach a final diagnosis.
Fasting is not required for the ASCA test. You can eat and drink normally unless your doctor advises otherwise.
The ASCA test is a simple blood test, and the risks are minimal. You may feel slight pain, bruising, or discomfort at the site where the needle is inserted, but these effects usually resolve quickly.
The need for repeat testing depends on the severity of your condition and your treatment plan. ASCA is mainly used for diagnosis rather than monitoring, so your doctor will decide whether additional testing is necessary during follow-up.
Yes. While a positive ASCA result is most strongly linked with Crohn’s disease, it may also be seen in other forms of inflammatory bowel disease and, in some cases, in conditions like celiac disease. This is why results should always be interpreted along with other clinical findings.
Yes, it is possible. Not all patients with Crohn’s disease have detectable ASCA antibodies. A negative result does not rule out the condition, and further tests are usually needed for an accurate diagnosis.
Both tests look for antibodies against Saccharomyces cerevisiae, but they measure different types. IgG antibodies are more common and circulate in the blood, while IgA antibodies are usually associated with mucosal surfaces such as the intestinal lining. Sometimes, both tests are ordered together for more diagnostic clarity.
Yes, although it is uncommon. A person without gastrointestinal symptoms may test positive, but this finding alone does not confirm the disease. Doctors usually investigate further only if there are related symptoms or risk factors.
No. Although Crohn’s disease is the condition most often associated with ASCA positivity, some patients with ulcerative colitis or other inflammatory conditions may also show positive results.
Tata 1mg ensures accurate lab test results through certified laboratories that use advanced technology and adhere to stringent quality control measures. This commitment to high standards guarantees reliable results.
Content created by
Written by:
Dr. Lipika Khurana
PGDHHM, BDS
Reviewed by:
Dr. Swati Gupta (Anand)
MBBS, MD Lab Medicine
Want to know moreRead our editorial policy
Last Updated15th Jun 2026

ASCA - IgG antibody test price for other cities

Price inKolkataRs. 1599
Price inNavi MumbaiRs. 2129
Price inNew DelhiRs. 1499
Price inThaneRs. 2129
Price inMumbaiRs. 2129

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ASCA - IgG antibody