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DOXIn 25mg Capsule

Written By Dr. Swati Mishra, BDS
Reviewed By Dr. Mekhala Chandra, MD, MBBS
Last updated on 07 Apr 2026 | 02:54 PM (IST)
DOXIn 25mg Capsule is a tricyclic antidepressant. It is used in the treatment of insomnia (difficulty in sleeping). It is also used in patients intolerant of or unresponsive to alternative (other) treatment options for depression and anxiety disorders.
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DOXIn 25mg Capsule
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General Information

The content is shown in English
DOXIn 25mg Capsule image
DOXIn 25mg Capsule image
DOXIn 25mg Capsule image
DOXIn 25mg Capsule image

Product introduction

DOXIn 25mg Capsule works by increasing the levels of chemical messengers in the brain that stabilizes and enhances the mood. It is usually advised to take it before bedtime because it can make you feel drowsy. It can be taken with or without food, but you should take it at a fixed time each day for better efficacy. The dose and duration will be decided by your doctor so that you get the right amount to control your symptoms. If you have missed any dose, take it as soon as you remember it. Do not skip any dose and finish the full course of treatment even if you feel better. This medication must not be stopped suddenly without talking to the doctor. Your dose may be modified or gradually decreased before stopping the medicine.

The most common side effects of this medicine include increased heart rate, blurred vision, dryness in the mouth, difficulty in urination, and constipation. Initially, this medicine may also cause a sudden drop in blood pressure, especially when you change positions. It may even cause dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you. To lower the chances of dizziness, rise slowly if you have been sitting or lying down. It may also lead to weight gain in some people. Most of the common side effects tend to be mild and temporary. Your doctor may be able to suggest ways of preventing or reducing side effects if they bother you or do not go away. Serious side effects associated with this medicine are rare.

Before taking this medicine, it is important to tell your doctor if you are taking or have recently taken any other medicines for the same or any other diseases. Pregnant and breastfeeding women should take this medicine with proper consultation and caution. This medicine is not known to be addictive, but you can experience additional side effects (withdrawal symptoms) if you stop taking it suddenly. If you notice any sudden mood change or get suicidal or self-harm thoughts, you must consult the doctor without delay. Also, remember to take this medicine as advised by the doctor as an overdose of this medication may lead to a serious health emergency. Consumption of alcohol should be avoided as alcohol interacts with this medicine to cause serious health issues.

Benefits of DOXIn Capsule

Treatment of Anxiety disorder
DOXIn 25mg Capsule reduces the symptoms of excessive anxiety and worry. It can also reduce feelings of restlessness, tiredness, difficulty concentrating, feeling irritable and sleep problems that often come with Anxiety Disorder. It will therefore help you go about your daily activities more easily and be more productive. Keep taking this medicine even if you feel well. Stopping suddenly can cause serious problems.

Side effects of DOXIn Capsule

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of DOXIn
  • Increased heart rate
  • Blurred vision
  • Constipation
  • Difficulty in urination
  • Dryness in mouth
  • Orthostatic hypotension (sudden lowering of blood pressure on standing)
  • Weight gain

How to use DOXIn Capsule

Take this medicine in the dose and duration as advised by your doctor. DOXIn 25mg Capsule may be taken with or without food.

How DOXIn Capsule works

DOXIn 25mg Capsule is a tricyclic antidepressant. It increases the levels of chemical messengers in the brain that help in regulating the mood and treat depression.

All substitutes for DOXIn 25mg Capsule

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

  • DOXIn 25mg Capsule helps in the treatment of insomnia, depression and anxiety.
  • Inform your doctor if you notice behavioral changes, mood changes and suicidal thoughts while taking this medicine. 
  • Inform your doctor if you notice a loss of consciousness, agitation, reduced breathing rate, convulsions, muscle rigidity, and mouth dryness.
  • You may be asked for regular blood tests to monitor the blood cell count or level of sodium and sugar in the blood.
  • Do not drive or do anything that requires concentration until you know how the medicine affects you.
  • Do not stop taking the medication suddenly without talking to your doctor.
  • The main dose should be taken at night as this medicine may produce drowsiness or sleepiness.
  • It can take 2 to 3 weeks for DOXIn 25mg Capsule to start working.
  • You should continue the treatment for at least 6 months after you feel better to stop depression from coming back.
  • If your doctor asks you to stop DOXIn 25mg Capsule, you should reduce the dose slowly over 4 weeks. You should not discontinue it abruptly.
  • Avoid driving or operating machinery as it may decrease alertness.
  • Avoid consuming alcohol when taking the DOXIn 25mg Capsule, as it may cause excessive drowsiness and calmness.
  • The addiction/dependence potential of DOXIn 25mg Capsule is very less.
  • It may be extremely dangerous in overdose. 

Safety advice

Alcohol

Alcohol

UNSAFE
Do not drink alcohol while you are taking this medicine. DOXIn 25mg Capsule may cause excessive drowsiness when taken with alcohol.
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
The safety of DOXIn 25mg Capsule during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
DOXIn 25mg Capsule may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.
The baby should be monitored carefully for excessive sleepiness, and adequate weight gain.
Driving

Driving

UNSAFE
DOXIn 25mg Capsule may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney

Kidney

SAFE IF PRESCRIBED
DOXIn 25mg Capsule is probably safe to use in patients with kidney disease. Limited data suggest dose adjustment may not be needed.
However, talk to your doctor if you have any underlying kidney disease.
Liver

Liver

CAUTION
DOXIn 25mg Capsule should be used with caution in patients with liver disease. Dose adjustment may be needed.

Interaction with drugs

Taking DOXIn with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Life-threatening

Moclobemide (Oral Route)

Do not consume Moclobemide with Doxepin. If Moclobemide is essential, ensure a gap of at least 1 day after discontinuing Doxepin. Please consult your doctor.
Life-threatening

Domperidone (Oral Route)

Do not consume Domperidone with Doxepin.
Life-threatening

Tranylcypromine (Oral Route)

Do not consume Tranylcypromine with Doxepin. If Tranylcypromine is essential, ensure a gap of at least 2 weeks after discontinuing Doxepin. Please consult your doctor.
Severe

Tramadol (Injection Route)

Careful consideration is advised if you have epilepsy. Watch out for symptoms of serotonin syndrome, such as sedation, respiratory impairment, tremors, fever, diarrhea, or agitation, and consult your doctor if you experience them. Your doctor may alter or discontinue the medicines accordingly.
Severe

Thioridazine (Oral Route)

If concurrent use is essential, watch out for symptoms such as sleepiness, dry mouth, impaired voluntary movements, weight gain, constipation, muscle stiffness or tremors and consult your doctor if you experience them. Factors such as old age, chronic heart issues, or low potassium levels may more frequently cause disturbance in heart rhythm, and your doctor may consider ECG monitoring in their presence.

Frequently asked questions

No, you should always check with your doctor before you stop taking DOXIn 25mg Capsule. Stopping the medicine abruptly may cause withdrawal effects. So, your doctor may reduce your dose gradually before taking you off the medicine completely. This helps to prevent a recurrence of the symptoms of depression and also reduces the chances of withdrawal symptoms.
Yes, stopping the use of DOXIn 25mg Capsule abruptly results in withdrawal symptoms which include insomnia (trouble falling asleep), irritability and excessive sweating. You should consult your doctor if you need to stop DOXIn 25mg Capsule. You doctor may gradually reduce the dose of DOXIn 25mg Capsule before taking you off DOXIn 25mg Capsule completely.
You should not take DOXIn 25mg Capsule if you have ever had an allergic reaction to antidepressant medicines (such as DOXIn 25mg Capsule), or any of the inactive ingredients of DOXIn 25mg Capsule. Avoid taking DOXIn 25mg Capsule if you have glaucoma (increased eye pressure), liver problems, any difficulty in passing urine, if you are pregnant or breastfeeding. Do not take DOXIn 25mg Capsule if you are taking or have taken monoamine oxidase inhibitors (MAOIs) in the last two weeks or, if you suffer from mania (where you experience an abnormally elevated and excitable mood). It should not be given to children under 12 years of age.
Taking DOXIn 25mg Capsule may cause sleepiness, so you should avoid driving or working with machinery until the effect has worn off. Driving while taking DOXIn 25mg Capsule may increase the risk of sleep-driving. This refers to driving while not fully awake after taking a sleeping medicine that can lead to decreased awareness of the surroundings and cause accidents.
Overdose of DOXIn 25mg Capsule can be mild or severe. Signs and symptoms of mild overdose include drowsiness, blurred vision and excessive dryness of the mouth. Severe overdose may cause loss of consciousness, difficulty breathing, convulsions, low blood pressure, unusually fast heartbeat or palpitations. If you take too much of DOXIn 25mg Capsule, contact your doctor immediately or seek emergency medical help.
It may take several weeks or longer for you to experience significant benefits of DOXIn 25mg Capsule. Do not stop taking DOXIn 25mg Capsule without talking to your doctor, even if you feel better.
Yes. DOXIn 25mg Capsule is also used for the treatment of insomnia (difficulty sleeping). It is especially helpful for people who have trouble staying asleep.
No, you should not drink alcohol while taking DOXIn 25mg Capsule as alcohol can increase the sleepiness or dizziness that occur as side effects of DOXIn 25mg Capsule.
Generally DOXIn 25mg Capsule does not cause dependence and is therefore not addictive. But, you should not stop taking DOXIn 25mg Capsule abruptly as it may cause temporary withdrawal symptoms such as insomnia (trouble falling asleep), irritability and excessive sweating.
Yes, DOXIn 25mg Capsule can cause suicidal thoughts. This is more common in people who have previously had thoughts about killing or harming themselves, are younger than 25 years of age with a history of psychiatric conditions and who have earlier been treated with an antidepressant. If you experience suicidal thoughts, contact your doctor or go to a hospital straight away. You may also find it helpful to talk to a relative or close friend.
DOXIn 25mg Capsule may cause weight gain as well as loss of appetite, but it is not very common. Call your doctor if any of these bother you.
DOXIn 25mg Capsule should be taken in the dose and duration advised by the doctor. Your dose will depend on the illness you are being treated for. If you are taking DOXIn 25mg Capsule for insomnia, you should take it 30 minutes just before bedtime and you should not do anything that needs mental focus. If you are taking it for depression or anxiety, take it exactly as directed by your doctor. Remember to take this medicine at the same time each day to avoid missing doses.
The side effects of DOXIn 25mg Capsule include increased heart rate, weight gain, dryness in mouth, orthostatic hypotension (sudden lowering of blood pressure on standing), constipation and difficulty in urination. It may make your skin more sensitive to sunlight, cause chills and excessive sweating. Please consult your doctor if any of these side effects worry you or do not go away.

Fact Box

Chemical Class

Dibenzoxepines

Habit Forming

No

Therapeutic Class

NEURO CNS

Action Class

Tricyclic Antidepressants (TCAs)

References

  1. Stahl SM, editor. Doxepin. In: Stahl's Essential Pschopharmacology: Prescriber's Guide. 5th ed. New York, New York: Cambridge University Press; 2014. pp. 211-17.
  2. Skidgel RA, Kaplan AP, Erdös EG. Histamine, Bradykinin, and Their Antagonists. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 923.
  3. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 430-31.
  4. Doxepin. San Diego: Somaxon Pharmaceuticals; 1969 [revised date]. [Accessed 22 Mar. 2019] (online) Available from:
  5. Chaves RG, Lamounier JA. Breastfeeding and maternal medications. J Pediatr (Rio J). 2004;80(5 Suppl):S189-S198. [Accessed 20 Mar. 2019] (online) Available from:
  6. Central Drugs Standard Control Organisation (CDSCO). [Accessed 22 Mar. 2019] (online) Available from:
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User feedback

Once A Day
79%
Twice A Day
21%
Others
67%
Insomnia
33%
Poor
67%
Average
33%
Weight gain
50%
Constipation
50%
With food
100%
Expensive
100%
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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Intas Pharmaceuticals Ltd
Address: Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India.

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Country of origin: India
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