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Domperidone is used in the treatment of heartburn and vomiting

How it works

Domperidone indirectly stimulates the release of acetylcholine, a chemical messenger that can increase the motility of the intestine.

Common side effects

Dry mouth

Available Medicine

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Expert advice

  • Do not take Domperidone, if you are allergic to it or to any other content in the tablets.
  • Do not take the medicine, if you notice black, tarry stools (bowel motions) or blood in your stools, blockage or tear in the intestines or if you have a tumor of the pituitary gland (prolactinoma).
  • Do not take the drug, if you have moderate to severe liver disease, heart problems (irregular heart rate or heart failure) or abnormal salt levels in the blood.
  • Do not crush or chew the tablets, swallow them whole with a glass of water.
  • Do not take the drug if you intend to drive or operate heavy machinery as it may cause drowsiness.
  • Always take the tablets 15 to 30 minutes before meals and, if needed, before going to bed at night.
  • Consult your doctor, if you are above 60 years of age and taking domperidone for a long period of time.
  • Inform your doctor, if you are already taking medicines for fungal infections (ketoconazole) or antibiotics (e.g. gentamycin, erythromycin).

Frequently asked questions



What is Domperidone/ domstal used for and how long can I take it?
Domperidone (also known as domstal) is used for the treatment of short-term (upto 48 hours) and long-term (upto 2 weeks) problems of nausea, vomiting, belching, gas, heartburn and bloating (not to be confused as laxative, steroid or antacid). Always take the drug exactly as your doctor has told you to


Is domperidone an over the counter drug?
No, domperidone is not an OTC drug and it is not advisable to take it without a prescription


Can I take domperidone with citalopram?
Domperidone may increase the sedative effect of citalopram and may interact with other drugs like antibiotics, pain-killers or anti-fungals. Consult your doctor if you are taking any of these medicines

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Does domperidone cause weight-gain?
No. Domperidone does not cause weight-gain. If you notice an abnormal weight-gain, visit your doctor


Does domperidone raise the blood pressure or cause depression?
These effects are generally not seen with use of domperidone. But if you are experiencing these side effects, please consult your doctor.

Content on this page was last updated on 24 February, 2017, by Dr. Varun Gupta (MD Pharmacology)