Glimepiride + Metformin + Voglibose is a combination of three antidiabetic medicines: Glimepiride, metformin and voglibose. They work by different mechanisms to provide better control of blood sugar when single or dual therapy is not effective. Glimepiride is a sulfonylurea which works by increasing the amount of insulin released by the pancreas to lower the blood glucose. Metformin is a biguanide which lowers glucose production in the liver, delays glucose absorption from intestines and increases the body's sensitivity to insulin. Voglibose is an alpha-glucosidase inhibitor which prevents breakdown of complex sugars into simple sugars such as glucose. This prevents the blood glucose levels from rising to very high levels after meals.
Xmet-Trio is a combination of three medicines: Glimepiride, Metformin and Voglibose. This medicine is used in the treatment of type 2 diabetes mellitus (DM). It improves the blood glucose levels in adults when taken along with proper diet and regular exercise. Glimepiride lowers the blood glucose levels by increasing the release of insulin from the pancreas. Metformin works by lowering the glucose production in the liver and improving insulin sensitivity. Voglibose is an alpha-glucosidase inhibitor which lowers the postprandial (after meals) glucose levels in the body. This combination is not indicated for the treatment of Type 1 DM.
Q. What are the possible side effects of Xmet-Trio?
The use of Xmet-Trio is associated with common side effects like hypoglycemia (low blood sugar level), nausea, diarrhea, altered taste, flatulence, stomach pain, headache, skin rash and respiratory tract infection.
Q. Are there any specific conditions in which Xmet-Trio should not be taken?
The use of Xmet-Trio should be avoided in patients with known allergy to any of the components or excipients of this medicine. The use of this medicine is also avoided in patients with moderate to severe kidney disease and in patients with inflammatory bowel disease, colonic ulcerations and underlying metabolic acidosis including diabetic ketoacidosis.
Q. Is it safe to take alcohol while I am also taking Xmet-Trio?
No, it is not safe to take Xmet-Trio along with alcohol. It may lower your low blood sugar levels (hypoglycemia) and can increase the chances of lactic acidosis.
Q. Can the use of Xmet-Trio cause hypoglycemia?
Yes, the use of Xmet-Trio can cause hypoglycemia (low blood sugar level). Symptoms of hypoglycemia include nausea, headache, irritability, hunger, sweating, dizziness, fast heart rate, and feeling anxious or shaky. It happens more often if you miss or delay your food, drink alcohol, over-exercise or take other antidiabetic medicine along with it. So, regular monitoring of blood sugar level is important. Always keep glucose tablets, honey or fruit juice with you.
Q. What are the instructions for the storage and disposal of Xmet-Trio?
Keep this medicine in the packet or the container it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.
Information last updated by Dr. Varun Gupta, MD Pharmacology on 14th May 2019. The medicine details are for information purpose only. Consult a doctor before taking any medicine.