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Glimepiride is used in the treatment of type 2 diabetes

How it works

Glimepiride increases the amount of insulin released by the pancreas, which in turn lowers the blood glucose levels.

Common side effects

Hypoglycemia (Low blood sugar level), Nausea, Headache, Dizziness

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Expert advice

  • The most common and serious side effect is hypoglycemia (low blood sugar level). If you consume excessive alcohol or if you have irregular dietary patterns, you are at an increased risk of hypoglycemia (low blood sugar level). Do not skip meals when taking this medicine.
  • Please be aware of signs and symptoms of low blood sugar (dizziness, tremor, sweating, headache).
  • Inform your doctor if you have ever been diagnosed with kidney or liver problems.
  • Tell your doctor if you are planning to get pregnant or pregnant or breastfeeding.
  • It should be avoided or use with caution if you are also taking nonsteroidal anti-inflammatory agents (NSAIDs), alcohol, β-blockers and ACE inhibitors.
  • Do not change the dose without consulting your doctor.

Frequently asked questions



Is glimepiride a generic drug?
Yes, glimepiride is a generic drug sold under several pharmaceutical brand names (Amaryl, Zoryl, etc.)


Can I take glimepiride with metformin or insulin?
Glimepiride may be given in combination with metformin and/or insulin depending on your medical condition and as prescribed by the doctor


Does glimepiride cause fluctuations in weight,diarrhea, hair loss, erectile dysfunction, swelling, constipation?
Glimepiride is reported to cause low blood sugar level,weight gain, and swelling, but is not reported to cause diarrhea, constipation, hair loss, or erectile dysfunction

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Is glimepiride a fast acting sulfa drug?
Glimepiride is a medium- to long-acting sulfonylurea drug against type 2 diabetes mellitus (action lasts for 24 hours). Its maximum effect is seen after 2-3 hours of drug intake


Is glimepiride same as glipizide, glyburide, metformin, or insulin?
They are not same. Glimepiride, glipizide and glyburide belong to the same class of drugs called sulfonylureas. Metformin belong to class called biguanides.Glimepiride causes release of insulin but it is not insulin.It should only be used if no other alternative drug is available. Please follow your doctor's advice regarding its use.

Content on this page was last updated on 10 March, 2017, by Dr. Varun Gupta (MD Pharmacology)