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    Information about Glimepiride

    Glimepiride uses

    Glimepiride is used in the treatment of type 2 diabetes mellitus. It is used along with diet and exercise to improve blood sugar control in adults with type 2 diabetes.

    How glimepiride works

    Glimepiride is an antidiabetic medication. It works by increasing the amount of insulin released by the pancreas in order to lower blood glucose.

    Common side effects of glimepiride

    Hypoglycemia (low blood sugar level), Headache, Nausea, Dizziness
    Content Details
    Written By
    Dr. Betina Chandolia
    MDS, BDS
    Reviewed By
    Dr. Lalit Kanodia
    MD (Pharmacology), MBBS
    Last updated on:
    10 Jan 2020 | 02:47 PM (IST)
    Want to know more?
    Read Our Editorial Policy

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    Expert advice for Glimepiride

    • Take it shortly before or with the first main meal of the day (usually breakfast). Avoid skipping meals.
    • Exercise regularly, eat a healthy diet and take your other diabetes medicines (if prescribed) alongside.
    • Monitor your blood sugar level regularly while you are taking this medicine. 
    • Be careful while driving or operating machinery until you know how Glimepiride affects you.
    • It can cause hypoglycemia (low blood sugar level) when used with other antidiabetic medicines, alcohol or if you delay or miss a meal.
    • Always carry some sugary food or fruit juice with you in case you experience hypoglycemic symptoms such as cold sweats, cool pale skin, tremor and anxiety.
    • Your doctor may check your liver function regularly. Inform your doctor if you develop symptoms, such as abdominal pain, loss of appetite, or yellowing of the eyes or skin (jaundice).

    Frequently asked questions for Glimepiride


    Q. Does Glimepiride make you sleepy?

    Glimepiride itself does not cause sleepiness. However, it may cause hypoglycemia (low blood sugar) when used with other anti-diabetes medicine. Because of this you may feel sleepy or problems in sleeping.

    Q. Is Glimepiride safe for kidneys?

    Glimepiride does not affect kidneys in patients with normal kidney function. However, its use should be avoided in patients with severe kidney disease since Glimepiride is principally eliminated by the kidneys.

    Q. Does Glimepiride cause memory loss?

    No, it is not known that Glimepiride causes memory loss. However, use of Glimepiride may cause low blood sugar which may cause problems with concentration and reduced alertness.

    Q. Who should not take Glimepiride?

    Glimepiride should be avoided by patients who are allergic to it, have severe kidney or liver disease, have G6PD-deficiency (an inherited condition affecting red blood cells), or are due to have surgery. Along with that, patients who are trying to get pregnant, are pregnant, or breastfeeding, or have insulin-dependent diabetes (type 1 diabetes mellitus) should also avoid taking Glimepiride.

    Q. How long does it take for Glimepiride to start working?

    Glimepiride takes about 2 to 3 hours to reduce blood sugar levels. You may not feel any difference, but this does not mean it is not working. So, continue the medication as directed by your doctor and if you have any concerns, discuss it with your doctor.

    Q. How long do I need to take Glimepiride? Can I stop the medication?

    Treatment for diabetes is usually for life. You may have to continue the treatment life long. Do not stop taking Glimepiride without talking to your doctor. If you stop taking Glimepiride suddenly your diabetes may get worse.

    Q. How and when to take Glimepiride?

    Glimepiride tablets are available in 1mg, 2mg, 3mg and 4mg doses. The dose and frequency of the medicine will be decided by your doctor. Generally, a single daily dose of Glimepiride is sufficient to control blood sugar levels. The dose should be taken whole with water shortly before or during breakfast, but if you skip breakfast then it should be taken shortly before or during your first main meal.

    Q. What can happen if I take more than the recommended dose of Glimepiride?

    Overdose of Glimepiride may significantly decrease your blood sugar levels (hypoglycemia). If you have taken an excess dose then you should instantly consume enough sugar (e.g., a small bar of sugar cubes, sweet juice or sweetened tea) and inform a doctor immediately. Severe cases of hypoglycemia accompanied by loss of consciousness and coma are cases of medical emergency requiring immediate medical treatment and admission into hospital.

    Content on this page was last updated on 10 January, 2020, by Dr. Varun Gupta (MD Pharmacology)