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Glimepiride is used in the treatment of type 2 diabetes

How it works

Glimepiride increases the amount of insulin released by the pancreas, which in turn lowers the blood glucose levels.

Common side effects

Fall in blood sugar level, Nausea, Headache, Dizziness

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Expert advice

  • Type 2 diabetes can be controlled with a proper diet alone or a diet along with exercise. A planned diet and exercising are always important when you have diabetes, even when you are taking antidiabetic medicines.
  • Low blood sugar is life-threatening. Low blood sugar may develop due to:
    • Delay or missing scheduled meals or snacks. 
    • Exercising more than usual. 
    • Drinking a significant amount of alcohol.
    • Using too much insulin. 
    • Sickness (vomiting or diarrhea).
  • Symptoms of low blood sugar (alarming signs) are fast heartbeat, sweating, cool and pale skin, feeling shaky, confusion or irritability, headache, nausea, and nightmares. Make sure that you have access to quick-acting sugar sources that treat low blood sugar. Consuming some form of quick-acting sugars immediately after the appearance of the symptoms will prevent the low blood sugar levels from worsening.
  • Consuming alcohol may increase the chance of severe low blood sugar.
  • Glimepiride does not help patients who have type 1 diabetes.

Frequently asked questions



Is glimepiride a generic drug?
Yes, glimepiride is a generic drug sold under several pharmaceutical brand names (Amaryl, Zoryl, etc.)


Can I take glimepiride with metformin or insulin?
Glimepiride may be given in combination with metformin and/or insulin depending on your medical condition and as prescribed by the doctor


Does glimepiride cause fluctuations in weight,diarrhea, hair loss, erectile dysfunction, swelling, constipation?
Glimepiride is reported to cause low blood sugar level,weight gain, and swelling, but is not reported to cause diarrhea, constipation, hair loss, or erectile dysfunction

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Is glimepiride a fast acting sulfa drug?
Glimepiride is a medium- to long-acting sulfonylurea drug against type 2 diabetes mellitus (action lasts for 24 hours). Its maximum effect is seen after 2-3 hours of drug intake


Is glimepiride same as glipizide, glyburide, metformin, or insulin?
They are not same. Glimepiride, glipizide and glyburide belong to the same class of drugs called sulfonylureas. Metformin belong to class called biguanides.Glimepiride causes release of insulin but it is not insulin.It should only be used if no other alternative drug is available. Please follow your doctor's advice regarding its use.

Content on this page was last updated on 22 February, 2017, by Dr. Varun Gupta (MD Pharmacology)