Onoctone 25 Tablet

Written By Dr. Lipika Khurana, PGDHHM, BDS

Reviewed By Dr. Mekhala Chandra, MD, MBBS

Last updated on 14 Apr 2026 | 04:20 PM (IST)

Onoctone 25 Tablet is a medicine known as a diuretic (water pill). It is mainly used in the treatment of heart failure and high blood pressure. It reduces the swelling (edema) caused by some other conditions. This medicine is also used to treat low potassium levels in the body (hypokalemia).

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General Information

Contains

Spironolactone (25mg)

Marketer

Zeelab Pharmacy Pvt Ltd

Storage

Store below 25°C

The content is shown in English

Product introduction

Onoctone 25 Tablet can be taken with or without food, but you should take it in the same way each time to get the most benefit. Taking it with food can reduce some side effects and taking it early in the day can prevent you from having to get up at night to go to the toilet. You should keep using this medicine as it has been prescribed, even if you feel well. If you stop taking it, your condition may get worse. Follow your doctor's advice about the type and amount of liquids you should drink. If you are being treated for high blood pressure, lifestyle changes such as taking regular exercise and changes to your diet may increase the effectiveness of this medicine.

The common side effects include feeling or being sick, vomiting, dizziness and swelling or tenderness of your breasts (men and women). If these bother you, or appear serious, let your doctor know. There may be ways of reducing or preventing them. Drinking alcohol can increase certain side effects.

You should be careful about using Onoctone 25 Tablet if you have kidney problems or are unable to urinate. Before taking it, tell your doctor if you have ever had kidney, liver or heart disease or are pregnant. Also let your healthcare team know about all other medications you are using as they may affect, or be affected by this medicine. This medicine should only be used if it is clearly needed during pregnancy and while breastfeeding. While using this medicine, you may be advised to limit your intake of salt or salt substitutes, and you should have your blood pressure checked frequently. Some other tests will be done to monitor your progress.

Uses of Onoctone Tablet

Benefits of Onoctone Tablet

Heart Failure
Heart failure means your heart is weak and cannot pump enough blood to your lungs and the rest of your body. The most common symptoms are breathlessness, tiredness, and swelling in your legs, ankles, abdomen, and other parts of your body.

This medicine will help relieve your symptoms, making you feel better and more energetic. You should make appropriate lifestyle changes (such as eating healthily and keeping active) to help this medicine be effective. Take it regularly and keep taking it even if you feel better.

Low potassium
Onoctone 25 Tablet prevents your body from absorbing too much salt, removes excess water and keeps your potassium levels from getting too low.

Side effects of Onoctone Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Onoctone

Nausea
Vomiting
Leg cramps
Dizziness
Drowsiness
Breast enlargement in male

How to use Onoctone Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Onoctone 25 Tablet should be taken with or after food.

How Onoctone Tablet works

Onoctone 25 Tablet is a potassium-sparing diuretic. It lowers blood pressure and swelling by removing the extra water and electrolytes from the body without loss of potassium.

All substitutes for Onoctone 25 Tablet

For information purposes only. Consult a doctor before taking any medicine.

aldactone Tablet

by RPG Life Sciences Ltd

₹2.15/tablet

26% costlier

Quick tips

It can make you feel dizzy for the first few days. Do not drive or do anything requiring concentration until you know how Onoctone 25 Tablet affects you.
It may increase the level of potassium in your blood. Avoid taking potassium supplements and potassium-rich foods such as banana and broccoli.
Your doctor will regularly check your kidney function and the amount of potassium in your blood while you are on this medicine.
Notify your doctor if you experience dizziness, diarrhea, vomiting, fast or irregular heartbeat, swelling in feet, or difficulty breathing.
Onoctone 25 Tablet may cause breast pain/swelling, irregular periods (women), or trouble with sexual performance.
Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Onoctone 25 Tablet. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

The safety of Onoctone 25 Tablet during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.

Breast feeding

CAUTION

Onoctone 25 Tablet should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from the body.

Driving

UNSAFE

Onoctone 25 Tablet may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Kidney

CAUTION

Onoctone 25 Tablet should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.

Liver

CAUTION

Onoctone 25 Tablet should be used with caution in patients with severe liver disease. Dose adjustment may be needed.

Interaction with drugs

Taking Onoctone with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Severe

Telmisartan (Oral Route)

If concurrent use is essential, watch out for symptoms such as dizziness, fatigue, confusion, weight loss, tingling in hands and feet, nausea, diarrhea, loss of appetite, difficulty concentrating, or taste changes, and consult your doctor if you experience them. They may adjust the doses as per the observations.

Severe

Losartan (Oral Route)

Severe

Olmesartan Medoxomil (Oral Route)

Severe

Ramipril (Oral Route)

Do not consume Ramipril with Spironolactone in case of kidney disorders. If concurrent use is essential, your doctor may closely monitor your kidney function and adjust or discontinue the medicines accordingly.

Severe

Abiraterone Acetate (Oral Route)

Do not consume Abiraterone Acetate with Spironolactone. Spironolactone may reduce the efficacy of Abiraterone Acetate.

Frequently asked questions

What is Onoctone 25 Tablet?

Onoctone 25 Tablet is a medicine that belongs to the class of medicines known as potassium-sparing diuretics (water tablets). Onoctone 25 Tablet being a diuretic helps lose excess fluid from your body. It is used to treat conditions such as high blood pressure, congestive heart failure, edema (swelling) or low potassium levels. Edema may be caused due to problems with your liver (cirrhosis or ascites) and kidney disorders (such as nephrotic syndrome).

What is the best time to take Onoctone 25 Tablet?

Onoctone 25 Tablet should be taken as directed by your doctor. Onoctone 25 Tablet helps remove excess fluids from the body which can make you pass more urine. Therefore, it would be best to take Onoctone 25 Tablet during the day so as to avoid the frequent urge to urinate during sleep.

Does Onoctone 25 Tablet treat hypertension?

Yes, Onoctone 25 Tablet effectively treats hypertension (high blood pressure). However, it is used in combination with other medicines to get maximum benefit. Onoctone 25 Tablet is a diuretic commonly known as a water tablet. It works by removing excess fluid from your body which helps in lowering your blood pressure. Onoctone 25 Tablet should be taken only when prescribed by the doctor.

What foods should I avoid while taking Onoctone 25 Tablet?

You should avoid taking an excess amount of salt or salt substitutes while taking Onoctone 25 Tablet. Try to avoid foods containing potassium or potassium substitutes such as bananas, coconut water, spinach, sweet potatoes and avocados. These foods may increase your potassium levels and this can be fatal. Consult your doctor to know more about other food choices to be avoided while taking Onoctone 25 Tablet.

Can I use Onoctone 25 Tablet for weight control?

No, Aldactone should not be used for weight control. Onoctone 25 Tablet is not helpful in weight management. If you have weight related concerns, please consult a doctor who will let you know the best therapy for weight control.

What other lifestyle changes should I make while taking Onoctone 25 Tablet?

Lifestyle changes play a major role in keeping you healthy if you are taking Onoctone 25 Tablet. Avoid taking excess salt in your diet and find ways to reduce or manage stress in your life. Practice yoga or meditation or take up a hobby. Ensure that you have a sound sleep every night as this also helps to reduce stress levels and helps to keep your blood pressure normal. Stop smoking and alcohol consumption as this helps in lowering your blood pressure and preventing heart problems. Exercise regularly and take a balanced diet that includes whole grains, fresh fruits, vegetables and fat-free products. Consult your doctor if you need any further guidance to get the maximum benefit of Onoctone 25 Tablet and to keep yourself healthy.

Can I take Onoctone 25 Tablet with birth control?

Onoctone 25 Tablet can be taken with birth control pills (oral contraceptives) as there are no reports which suggest possible interactions or side effects while using these medicines together. However, in some cases, interactions may occur. Therefore, it would be best to first talk to your doctor before taking Onoctone 25 Tablet with any birth control pills (oral contraceptives).

Is Onoctone 25 Tablet harmful to the kidneys?

Onoctone 25 Tablet can lead to acute kidney failure particularly in those who already have impaired kidney function. Therefore, inform your doctor if you have kidney-related problems as you may need a different dose. In such cases, the doctor may suggest kidney function tests and closely monitor your condition.

Fact Box

Chemical Class

Spironolactone derivative

Habit Forming

Therapeutic Class

CARDIAC

Action Class

Potassium-Sparing Diuretics

Related lab tests

Kidney Function Test

Potassium

Sodium

Urine Potassium

References

Reilly RF, Jackson EK. Regulation of Renal Function and Vascular Volume. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 692-95.
Pfeffer MA, Opie LH. Inhibitors of the Renin-Angiotensin-Aldosterone System. In: Opie LH, Gersh BJ, editors. Drugs for the Heart. 8th ed. Philadelphia, Pennsylvania: Elsevier Saunders; 2013. pp. 159-61.
Chrousos GP. Adrenocorticosteroids & Adrenocortical Antagonists. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 695.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1278-79.
Chaves RG, Lamounier JA. Breastfeeding and maternal medications. J Pediatr (Rio J). 2004;80(5 Suppl):S189-S198. [Accessed 19 Mar. 2019] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 19 Mar. 2019] (online) Available from:
Spironolactone [Prescribing Information]. New York, NY: G.D. Searle LLC; 2018. [Accessed 20 Feb. 2024] (online) Available from:

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Zeelab Pharmacy Pvt Ltd
Address: 913, D-104, Pitampura, Delhi-110034

Vendor Details

Country of origin: India

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Why we need a prescription?

Onoctone 25 Tablet

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General Information

Contains

Marketer

Storage

Product introduction

Uses of Onoctone Tablet

Benefits of Onoctone Tablet

Side effects of Onoctone Tablet

How to use Onoctone Tablet

How Onoctone Tablet works

All substitutes for Onoctone 25 Tablet

aldactone Tablet

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Telmisartan (Oral Route)

Losartan (Oral Route)

Olmesartan Medoxomil (Oral Route)

Ramipril (Oral Route)

Abiraterone Acetate (Oral Route)

Frequently asked questions

What is Onoctone 25 Tablet?

What is the best time to take Onoctone 25 Tablet?

Does Onoctone 25 Tablet treat hypertension?

What foods should I avoid while taking Onoctone 25 Tablet?

Can I use Onoctone 25 Tablet for weight control?

What other lifestyle changes should I make while taking Onoctone 25 Tablet?

Can I take Onoctone 25 Tablet with birth control?

Is Onoctone 25 Tablet harmful to the kidneys?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

Related lab tests

Kidney Function Test

Potassium

Sodium

Urine Potassium

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

Related/Popular tests