Medicine Overview of Naxdu Tablet
Naxdu 30mg Tablet is used in the treatment of depression
, anxiety disorder, diabetic nerve pain
, fibromyalgia, neuropathic pain and stress urinary incontinence.
Nausea, Headache, Dryness in mouth, Sleepiness, Dizziness.
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Naxdu 30mg Tablet may be taken with or without food, but it is better to take it at a fixed time.
Naxdu 30mg Tablet works by increasing the levels of chemical messengers (serotonin and noradrenaline), natural substances in the brain that help maintain mental balance and stop the movement of pain signals in the brain.
In Depth Information on Naxdu Tablet
You may have to wait for 2 to 4 weeks to get the full effect.
- If your doctor asks you to stop Naxdu 30mg Tablet, you should not discontinue it abruptly. Many patients tolerate decreasing 50% dose every 3 days however if the withdrawal symptoms emerge during tapering it would require more gradual tapering over few weeks.
- Inform your doctor if you have ever been diagnosed with any heart problems (heart attack, heart failure, slow or irregular heart rate).
- Inform your doctor if you have ever been diagnosed with kidney or liver problems.
It can cause a sensation of restlessness or an inability to sit or stand still. This is most likely to occur within the first few weeks of treatment. You should tell your doctor if this happens to you.
- It may be more effective in some patients with depression who fails to respond to selective serotonin receptor inhibitors (SSRI) e.g. Fluoxetine.
- Monitor blood pressure (BP) frequently.
Naxdu Tablet related warnings
Naxdu 30mg Tablet may cause excessive drowsiness and calmness with alcohol.
WEIGH RISKS VS BENEFITS
Naxdu 30mg Tablet may be unsafe to use during pregnancy.
Animal studies have shown adverse effects on the foetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor.
Naxdu 30mg Tablet is probably unsafe to use during lactation.
Limited human data suggest that the drug could represent a significant risk to the baby.
Naxdu 30mg Tablet may make you feel dizzy, sleepy, tired, or decrease alertness. If this happens, do not drive.
Naxdu 30mg Tablet should be used with caution in patients with severe kidney disease. Dose adjustment of Naxdu 30mg Tablet may be needed. Please consult your doctor.
Dose adjustment is not recommended in patients with mild and moderate kidney disease.
Naxdu 30mg Tablet is probably unsafe to use in patients with liver disease and should be avoided. Please consult your doctor.
If you miss a dose of Naxdu 30mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Frequently asked questions about Naxdu Tablet
No. Naxdu is not a non-steroidal anti-inflammatory drug (NSAID). It belongs to the anti-depressant class of drugs, more specifically SNRI (Serotonin-Norepinephrine Reuptake Inhibitor). It works by increasing the levels of chemical messengers (serotonin and noradrenaline) in the nervous system.
No. Naxdu is not a steroid. It belongs to the anti-depressant class of drugs, more specifically SNRI (Serotonin-Norepinephrine Reuptake Inhibitor). It works by increasing the levels of chemical messengers (serotonin and noradrenaline) in the nervous system.
No. Naxdu is not a blood thinner. Blood thinners prevent the formation of harmful blood clots.
No. Naxdu is not a stimulant. Stimulants are the medicines which activate the central nervous system.
No. Naxdu is not a classical painkiller e.g. Non-Steroidal Anti-Inflammatory Drugs (NSAIDs).Duloxetine is used for the treatment of chronic pain conditions like neuropathic pain, diabetic neuropathy or fibromyalgia.
No. Naxdu is not a tricyclic antidepressant (TCA). It belongs to a class of anti-depressants called SNRIs (Serotonin-Norepinephrine Reuptake Inhibitors).
No. Naxdu is not a benzodiazepine. It belongs to a class of anti-depressants called SNRIs (Serotonin-Norepinephrine Reuptake Inhibitors). Benzodiazepines belong to the sedative-hypnotic class of drugs and include agents like diazepam, lorazepam, alprazolam etc.
No. Naxdu is not a narcotic. It means it does not have habit-forming potential. Narcotics are the substance which can cause addiction and dependence.
Yes. A psychotropic is a medicine that affects mind, emotions, and behaviour. Naxdu, being an anti-depressant agent reduces the symptoms of depression and is a psychotropic agent.
Naxdu should be used with caution in patients with Hepatitis C virus infection. Cases of liver injury, including severe elevations of liver enzymes (>10-times upper limit of normal), hepatitis, and jaundice have been reported with Naxdu. Taking Naxdu increases the risk of liver toxicity and fatty liver in Hepatitis C virus-infected patients.<br>
The maximum plasma concentration [Cmax] of Naxdu is 6 hours post oral dose. Food taken with Naxdu may delay the time to reach the peak plasma concentration from 6 to 10 hours. This may marginally decrease the extent of absorption (approximately 11%).
Q. Can I take Naxdu with Vitamin D?
Yes. Naxducan be taken with vitamin D. It does not have any known interaction with Vitamin D.
The elimination half-life of Naxdu ranges from 8 to 17 hours (mean 12 hours).
Q. Which is better in depression, Naxdu or fluoxetine?
Fluoxetine has not been found to be different in either tolerability or efficacy when compared with Naxdu in major depression. Naxdu is good for treating depression, anxiety and may help with chronic pain.
Q. Which is better Naxdu vs sertraline?
Naxdu and sertraline are found to be equally effective in the treatment of Major Depressive Disorder (MDD). Certain symptoms like agitation and anxiety are reduced better by sertraline. Naxdu has been found to be better than sertraline for neuropathic pain.
Q. Which is better for chronic pain, Naxdu or pregabalin?
In patients with fibromyalgia Naxdu is found to be better than pregabalin in reducing depressed mood. Pregabalin is better in reducing fatigue. Naxdu and pregabalin generally provide equally comparable pain relieving efficacy in the treatment of diabetic peripheral neuropathic pain (DPNP).
Q. Which is better Naxdu or fluoxetine?
Naxdu has been found to be better for the treatment of chronic pain than Fluoxetine. Fluoxetine is good for treating depression and anxiety.
Q. Which is better for depression, Naxdu or mirtazapine?
Currently, there is not enough information to firmly recommend one antidepressant over another. However, both these drugs have been found to be safe and efficacious in the treatment of depression.
Q. Which is better for depression, Naxdu or venlafaxine?
Currently, there is not enough information to firmly recommend one antidepressant over another. Many doctors favour Naxdu over venlafaxine when pain conditions coexist with depression.
No. Naxdu is not a barbiturate. Barbiturates belong to the Sedative-Hypnotic class of drugs and are likely to have abuse potential.
Naxdu can cause difficulty in sleep (insomnia). Hence, it is advised to be taken in the morning than at night.
Usually, the action of Naxdu takes about three to four weeks to appear. Do not discontinue the therapy in between, thinking that it is not effective.
Overdose can occur at a doses as low as 1000 mg. Signs and symptoms of overdose (duloxetine alone or in combination with other medicinal products) included somnolence, coma, serotonin syndrome, seizures, vomiting and tachycardia.
Naxdu is thought to work by interfering with certain chemicals (called serotonin and noradrenaline) that are used within the nerves that send messages to your pelvic floor muscles. This helps the muscles around the bladder outlet to contract more strongly, and this in turn controls the flow of urine and helps to prevent any leakage.
Q. Can I take Naxdu with amitriptyline?
It is better to avoid Naxdu and amitriptyline together. It can increase the risk of a serious condition called the serotonin syndrome, with symptoms such as confusion, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea.
Q. Can I take Naxdu with sertraline?
It is better to avoid Naxdu and sertraline together. It can increase the risk of a serious condition called the serotonin syndrome, with symptoms such as confusion, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea.
Q. Can I take Naxdu with tramadol?
Naxdu and tramadol together can increase the risk of a serious condition called the serotonin syndrome, with symptoms such as confusion, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea. Please inform your doctor if you are taking any of these medicines before coming to him.
Q. Can I take Naxdu with bupropion?
Bupropion can cause inhibition of metabolism of Naxdu in the body, resulting in toxic effects of Duloxetine. The concomitant use of these two drugs can result in seizures. Mention it to your doctor if you are taking any of these medications from before.
Q. Which is better in diabetic neuropathy, duloxetine or pregabalin?
In patients with fibromyalgia, Naxdu is found to be better than pregabalin in reducing depressed mood. Pregabalin is better in reducing fatigue. Naxdu and pregabalin generally provide equally comparable pain relieving efficacy in the treatment of diabetic peripheral neuropathic pain (DPNP).
No. Naxdu does not cause a high. It does not create a feeling of euphoria and has no recreational potential.
Naxdu is not approved for the treatment of arthritis. It is used in the treatment of depression, anxiety disorder, diabetic nerve disease, neuropathic pain and overactive urinary bladder.
No, Naxdu is not approved for the treatment of sciatica. It is used in the treatment of depression, anxiety disorder, diabetic nerve disease, neuropathic pain and overactive urinary bladder.
Obsessive-compulsive disorder (OCD) is a type anxiety disorder. It is approved for the treatment of obsessive-compulsive disorder. Research studies suggest that Naxdu may provide a significant reduction in symptoms for patients with obsessive-compulsive disorder.
No. Naxdu is not approved for use in hot flashes. It may be used in the treatment of depression in postmenopausal women suffering from menopausal vasomotor symptoms (hot flashes, night sweats) and insomnia.
No, Duloxetine is not approved for use in headaches. It is used in the treatment of depression, anxiety disorder, diabetic nerve disease, neuropathic pain and overactive urinary bladder.
No. Naxdu is not approved for use in a migraine. It is used in the treatment of depression, anxiety disorder, diabetic nerve disease, neuropathic pain and overactive urinary bladder.
Naxdu is approved for the treatment of chronic pain states including neuropathic pain (nerve pain) associated with Diabetes Mellitus and fibromyalgia.
Yes. Naxdu is approved for use in nerve pain or neuropathic pain conditions, most commonly seen in patients suffering from Diabetes Mellitus.
No. Naxdu may affect blood sugar levels. If you are diabetic and notice a change in the results of your blood or urine sugar tests, check with your doctor.
Severely interacts with other drugs like
Taking Naxdu with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
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