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How it works

Selegiline works by increasing the amount of dopamine, a chemical messenger that is needed to control movement in the brain.

Common side effects

Joint pain, Insomnia (difficulty in sleeping), Peripheral edema, Influenza like symptoms, Depression, Dyspepsia, Cough

Available Medicine

  • ₹46 to ₹51
    Intas Pharmaceuticals Ltd
    2 variant(s)
  • ₹31
    Themis Medicare Ltd
    1 variant(s)
  • ₹37
    Sun Pharmaceutical Industries Ltd
    1 variant(s)
  • ₹49
    Sanofi India Ltd
    1 variant(s)

Expert advice

  • Inform the doctor if you are suffering from hypertension, chest pain, palpitation (thumping, pounding or fluttering sensation in the chest), irregular heartbeat (arrhythmia), liver or kidney problems, stomach ulcers, sleep problems, glucose intolerance, and phenylketonuria (an inherited condition in which a special diet must be followed to prevent mental retardation).
  • Inform the doctor if you are being treated for any mental illness or have history of any unusual urges and/or behaviors (such as excessive gambling or excessive sexual behavior).
  • Seek advice if you are planning to undergo any surgery as selegiline may interfere with general anaesthetics.
  • Do not drink alcohol as it may worsen the side effects.
  • Do not drive or operate any machinery if selegiline affects your alertness.
  • At least 14 days should lapse between the discontinuation of selegiline and initiation of treatment with any drug known to interact with selegiline such as moclobemide, rasagiline, antidepressants, etc.

Frequently asked questions



Is selegiline safe?
Selegiline is safe if used at doses and for duration advised by your doctor


Is selegiline a stimulant?
Selegiline can stimulate the brain to cause mood changes, anxiety, agitation, hallucinations, confusion, sleep disturbances etc


Is selegiline addictive?
Selegiline is not addictive

Show More

Is selegiline a dopamine agonist?
Selegiline is not a dopamine agonist. It enhances the action of dopamine (either natural dopamine or dopamine obtained from conversion of levodopa) in brain by preventing its breakdown


Does selegiline need to be tapered?
Selegiline needs to be tapered and should not be suddenly stopped as it may cause fever, sweating, stiff muscles, and loss of consciousness if abruptly discontinued


Is selegiline neuroprotective?
Selegiline is neuroprotective as it slows the progression of Parkinson's disease


Does selegiline cause weight loss/weight gain?
Selegiline causes weight loss.

Content on this page was last updated on 27 March, 2017, by Dr. Varun Gupta (MD Pharmacology)