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Zolmitriptan is used to treat the symptoms of migraine headaches (severe throbbing headaches that sometimes are accompanied by nausea and sensitivity to sound and light).

How it works

Zolmitriptan belongs to a class of medications called selective serotonin receptor agonists. It works by narrowing blood vessels around the brain, stopping pain signals from being sent to the brain, and blocking the release of certain natural substances that cause pain, nausea, and other symptoms of migraine.

Common side effects

Vomiting, Nausea, Diarrhoea, Dizziness, Dry mouth, Eye swelling, Altered heart rate, Increased sweating, Loss of appetite, Rash, Weakness, Numbness of extremity


Expert advice

  • Before taking zolmitriptan tell your doctor, if you have any liver or kidney disease, seizures (e.g. epilepsy), heart disease (e.g., irregular heartbeat), or other types of headaches (e.g., cluster headaches).
  • Tell your doctor if you are taking a monoamine oxidase A (MAO-A) inhibitor such as isocarboxazid (Marplan), phenelzine (Parnate), or tranylcypromine (Nardil) for depression or if you have taken one of these medications in the past 2 weeks.
  • Zolmitriptan may cause dizziness. Do not drive or operate machinery or do any activity that requires alertness until you are sure you can perform such activities safely.
  • Use zolmitriptan as soon as you notice the headache symptoms of a migraine attack.
  • You must wait at least 2 hours between doses of zolmitriptan.
  • Overuse of zolmitriptan can worsen your headache. Do not take more than the recommended dose without checking with your doctor.
  • You may need to undergo lab tests, including heart function and blood pressure, to monitor your condition while you use zolmitriptan. 
  • Tell your doctor if you are or planning to become pregnant or are breastfeeding.

Frequently asked questions


Q. Is zolmitriptan a narcotic/addictive/blood thinner?
Zolmitriptan is not a narcotic or addictive or blood thinner.
Q. Can I take zolmitriptan with Paracetamol/ amitriptyline/ Aspirin/ Ibuprofen/ Cymbalta/ Vicodin/ Naproxen/ Tylenol?
Zolmitriptan may interact with these medications. Kindly follow doctors instructions. 
Q. Does zolmitriptan get you high?
Ziprasidone may cause side effects. Call your doctor if you experience any unusual problems during your treatment with Zolmitriptan.

Content on this page was last updated on 30 September, 2016, by Dr. Varun Gupta (MD Pharmacology)