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Zolmitriptan is used in acute attack of migraine.

How it works

Migraine headaches are thought to result from the dilatation of blood vessels in the head. A Zolmitriptan works by constricting (narrowing) these blood vessels, thus relieving the migraine headache.

Common side effects

Vomiting, Nausea, Diarrhoea, Dizziness, Dry mouth, Eye swelling, Altered heart rate, Increased sweating, Loss of appetite, Rash, Weakness, Numbness of extremity


Expert advice

  • Before taking zolmitriptan tell your doctor, if you have any liver or kidney disease, seizures (e.g. epilepsy), heart disease (e.g., irregular heartbeat), or other types of headaches (e.g., cluster headaches).
  • Tell your doctor if you are taking a monoamine oxidase A (MAO-A) inhibitor such as isocarboxazid (Marplan), phenelzine (Parnate), or tranylcypromine (Nardil) for depression or if you have taken one of these medications in the past 2 weeks.
  • Zolmitriptan may cause dizziness. Do not drive or operate machinery or do any activity that requires alertness until you are sure you can perform such activities safely.
  • Use zolmitriptan as soon as you notice the headache symptoms of a migraine attack.
  • You must wait at least 2 hours between doses of zolmitriptan.
  • Overuse of zolmitriptan can worsen your headache. Do not take more than the recommended dose without checking with your doctor.
  • You may need to undergo lab tests, including heart function and blood pressure, to monitor your condition while you use zolmitriptan. 
  • Tell your doctor if you are or planning to become pregnant or are breastfeeding.

Frequently asked questions


Q.Is zolmitriptan a narcotic/addictive/blood thinner?
Zolmitriptan is not a narcotic or addictive or blood thinner

Q.Can I take zolmitriptan with Paracetamol/ amitriptyline/ Aspirin/ Ibuprofen/ Cymbalta/ Vicodin/ Naproxen/ Tylenol?
Zolmitriptan may interact with these medications. Kindly follow doctors instructions

Q.Does zolmitriptan get you high?
Ziprasidone may cause side effects. Call your doctor if you experience any unusual problems during your treatment with Zolmitriptan.

Content on this page was last updated on 28 November, 2016, by Dr. Varun Gupta (MD Pharmacology)