How long does Combac 30 Tablet take to work?

In people with depression and anxiety, Combac 30 Tablet mostly starts working within two weeks of treatment. However, you may take 2-4 weeks to feel better. Consult your doctor if you do not see any improvement after this time. In people with diabetic neuropathic pain, you may take a few weeks to feel better. Consult your doctor if you do not feel better after 2 months.

If I start feeling better, can I stop taking Combac 30 Tablet?

No, you should not stop Combac 30 Tablet suddenly and without consulting your doctor. In cases of depression and anxiety, if you have been feeling better for 6 months or more, your doctor may reduce your doses gradually. In case of pain and incontinence, if you are feeling better, continue taking it for the long term. Your doctor will keep monitoring your response to the medicine every few months.

Is Combac 30 Tablet highly addictive?

No, Combac 30 Tablet is not habit-forming (addictive). This means that it does not make you physically or psychologically dependent on it.

What will be the consequences if I stop taking Combac 30 Tablet suddenly?

If you stop Combac 30 Tablet suddenly, you may feel dizzy, tired, agitated or restless, anxious and irritated. You may also experience sleep disturbances (vivid dreams, nightmares, inability to sleep), nausea, vomiting, shaking, muscle pain, diarrhea, a piercing sensation (pins and needles) especially in the head, and excessive sweating or vertigo. Always consult your doctor before you stop taking Combac 30 Tablet. Your doctor will reduce the dose gradually.

I am taking warfarin, does Combac 30 Tablet interfere with warfarin? Is it safe to take both together?

You should be cautious if you are taking both Combac 30 Tablet and warfarin since there is a risk of bleeding or you may experience petechiae or purpura.

Is Combac 30 Tablet safe to use for long term?

Combac 30 Tablet is safe to use for a long duration, provided you follow your doctor’s advice regarding the treatment.

I am a hypertensive patient. I have noticed that my blood pressure has increased after I started taking Combac 30 Tablet. Is it because of Combac 30 Tablet, what should be done?

Combac 30 Tablet may cause an increase in blood pressure. Therefore, regular monitoring of blood pressure is required, especially during the first month of use. If your blood pressure increase is constant, consult your doctor. It may indicate that your Combac 30 Tablet dose either needs to be reduced or discontinued gradually.

Combac 30 Tablet

Duloxetine (30mg)

Combac 30 Tablet is used in the treatment of depression, anxiety disorder, diabetic nerve pain, fibromyalgia (a condition in which there are generalized pain and tenderness in the body), neuropathic pain, and stress urinary incontinence.

Written By Dr. Sakshi Jain, MS, BDS,
Reviewed By Dr. Sachin Gupta, MD Pharmacology, MBBS,
Last updated on 27 Jul 2026 | 01:01 AM (IST)

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General Information

Contains

Duloxetine (30mg)

Marketer

Consern Pharma Limited

Storage

Store below 30°C

Product introduction

Combac 30 Tablet works by increasing the level of chemical messengers (serotonin and noradrenaline) in the brain that have a calming effect on the brain and relax the nerves, thus treating your illness. It may be taken with or without food. It is advised to take this medicine at a fixed time each day to maintain a consistent level in the blood. If you miss any doses, take it as soon as you remember. Do not skip any doses and finish the full course of treatment even if you feel better. This medication mustn't be stopped suddenly as it may worsen your symptoms.

Some common side effects of this medicine include nausea, headache, decreased libido, abnormal dreams, blurred vision, and dry mouth. It even causes dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you. However, these side effects are temporary and usually resolve on their own in some time. Please consult your doctor if these do not subside or bother you.

Before taking Combac 30 Tablet, inform your doctor if you have any problems with your kidneys, heart, liver, or have a history of seizures (epilepsy or fits). Inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or if you have any suicidal thoughts.

Uses of Combac Tablet

Diabetic nerve pain
Depression
Anxiety disorder
Neuropathic pain
Overactive bladder (OAB)
Fibromyalgia
Treatment of Stress urinary incontinence

Benefits of Combac Tablet

Treatment of Stress urinary incontinence
Stress urinary incontinence refers to the loss of urine without conscious intention. It may occur due to a disturbed state of mind and thoughts. Combac 30 Tablet helps in increasing the activity of those nerves in the brain that control muscles in our bladder that are responsible for passing urine. This helps in improving bladder control.

Side effects of Combac Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Combac

Nausea
Headache
Dryness in mouth
Sleepiness
Dizziness
Blurred vision
Decreased libido
Abnormal dreams

How to use Combac Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Combac 30 Tablet may be taken with or without food.

How Combac Tablet works

Combac 30 Tablet works by increasing the levels of chemical messengers (serotonin and noradrenaline), natural substances in the brain that help maintain mental balance and stop the movement of pain signals in the brain.

All substitutes for Combac 30 Tablet

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

Combac 30 Tablet helps in treating depression and anxiety.
It may also be used to treat nerve pain from diabetes and some other forms of chronic pain.
It may take 2 to 4 weeks for Combac 30 Tablet to start working. Keep taking it as prescribed.
It may cause dizziness and sleepiness. Do not drive or do anything requiring concentration until you know how it affects you.
Avoid consuming alcohol when taking Combac 30 Tablet as it may cause excessive drowsiness and increase the risk of liver damage.
It may cause a sensation of restlessness, especially when you first start taking it. Inform your doctor if this happens to you.
Talk to your doctor if you notice sudden mood changes or develop suicidal thoughts.
Do not stop taking the medication suddenly without talking to your doctor.

Safety advice

Alcohol

UNSAFE

It is unsafe to consume alcohol with Combac 30 Tablet

Pregnancy

CONSULT YOUR DOCTOR

Combac 30 Tablet is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.

Breast feeding

CONSULT YOUR DOCTOR

Combac 30 Tablet may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.

Driving

UNSAFE

Combac 30 Tablet may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Kidney

CAUTION

Combac 30 Tablet should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.

Liver

UNSAFE

Combac 30 Tablet is unsafe to use in patients with liver disease and should be avoided.

Fact Box

Chemical Class

Naphthalene derivative

Habit Forming

Therapeutic Class

NEURO CNS

Action Class

Serotonin Norepinephrine Reuptake Inhibitors (SNRIs)

References

Stahl SM, editor. Duloxetine. In: Stahl's Essential Pschopharmacology: Prescriber's Guide. 5th ed. New York, New York: Cambridge University Press; 2014. pp. 219-24.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 442-43.
Duloxetine hydrochloride. Basingstoke, Hampshire: Eli Lilly and Company Limited; 2004 [revised 09 Nov. 2018]. [Accessed 23 Jan. 2019] (online) Available from:
Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Duloxetine. [Updated 2020 Jan 20]. [Accessed 20 Feb. 2020] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 22 Mar. 2019] (online) Available from:

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Consern Pharma Limited
Address: 70-71, Ramnik Estate, Village Gonspur, P.O. Nurpur - 141008; H.O.: 308-C, BRS Nagar, Ludhiana, Punjab - 141012, India

Vendor Details

Country of origin: India

Why we need a prescription?

Name: Consern Pharma Limited
Address: 70-71, Ramnik Estate, Village Gonspur, P.O. Nurpur - 141008; H.O.: 308-C, BRS Nagar, Ludhiana, Punjab - 141012, India

Combac 30 Tablet

Save more with additional offers

General Information

Contains

Marketer

Storage

Product introduction

Uses of Combac Tablet

Benefits of Combac Tablet

Side effects of Combac Tablet

How to use Combac Tablet

How Combac Tablet works

All substitutes for Combac 30 Tablet

Symbal 30 Tablet

Duvanta 30 Tablet

Duloxee 30 Tablet

DUlotin 30mg Tablet

Duloren 30mg Tablet

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class