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TOPirol 50 Tablet

Topiramate (50mg)

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TOPirol 50 Tablet is a medicine used to treat epilepsy (seizures) and to prevent migraines. It is also used in the treatment of Lennox-Gastaut syndrome (a rare, but severe form of epilepsy that starts in early childhood).

Written By Dr. Syeda Aafia, MBA, BDS,
Reviewed By Dr. Mekhala Chandra, MD, MBBS,
Last updated on 23 Jan 2026 | 10:15 AM (IST)

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General Information

Contains

Topiramate (50mg)

Marketer

Sun Pharmaceutical Industries Ltd

Storage

Store below 30°C

The content is shown in English

Product introduction

TOPirol 50 Tablet may be taken with or without food, preferably at the same time, each day. If you have missed a dose, take it as soon as you remember it and finish the full course of treatment even if you feel better. Stopping the medication suddenly without talking to your doctor may cause an increased frequency of seizures. Your doctor may advise regular monitoring of serum bicarbonate levels while you are taking this medicine.

Some of the common side effects of this medicine include nausea, taste change, fatigue, diarrhea, weight loss, loss of appetite, and memory impairment. It may also cause vision problems like myopia or glaucoma, so it is important to get your eyesight checked before you start the treatment and regularly thereafter. You may experience dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you. Please consult your doctor if these side effects bother you or do not go away.

Uses of TOPirol Tablet

Benefits of TOPirol Tablet

Epilepsy/Seizures
TOPirol 50 Tablet is an anticonvulsant (or anti-epileptic) medicine that works by decreasing the nerve impulses which cause the seizures. By controlling the frequency of seizures, it will help you go about your daily activities with more confidence. It helps reduce symptoms such as confusion, uncontrollable jerking movements, loss of awareness, and fear or anxiety.
This medicine is not associated with any physical or psychological dependence (addiction) but it should not be stopped suddenly. It must be taken regularly as prescribed to be effective. Missing doses may trigger a seizure.

Lennox–Gastaut syndrome
Lennox-Gastaut syndrome (LGS) is a rare but severe form of epilepsy that usually starts in early childhood. Affected children may experience several different types of seizures. TOPirol 50 Tablet helps prevent and control these seizures by decreasing the nerve impulses which cause the seizures.

Migraine
Migraine is a condition marked by repeated headaches that can interfere with daily activities. TOPirol 50 Tablet helps reduce how often migraine attacks occur and lowers their intensity over time. Regular use supports better migraine control and helps improve day-to-day functioning and quality of life.

Side effects of TOPirol Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of TOPirol

Abdominal pain
Diarrhea
Dizziness
Fatigue
Fever
Loss of appetite
Memory impairment
Nausea
Nervousness
Numbness
Psychomotor impairment
Sleepiness
Speech disorder
Taste change
Upper respiratory tract infection
Visual impairment
Weight loss

How to use TOPirol Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. TOPirol 50 Tablet may be taken with or without food.

How TOPirol Tablet works

TOPirol 50 Tablet is an antiepileptic medication. It controls seizures or fits by decreasing the abnormal and excessive activity of the nerve cells in the brain.

All substitutes for TOPirol 50 Tablet

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

Take your medication regularly as directed by your doctor as missing doses can trigger seizures.
Do not change the brand of your medicine and make sure that you have sufficient amount of medicine present with you.
Some healthy tips to prevent seizures:
- Practice yoga every day.
- Get enough sleep at nighttime.
- Limit the use of screen time such as mobile/laptop.
- Take your medication on time.
It may cause dizziness and sleepiness. Do not drive or do anything that requires mental focus until you know how it affects you.
Keep yourself hydrated by drinking plenty of fluids throughout the day while taking TOPirol 50 Tablet. This can reduce the risk of kidney stones.
Monitor your weight during treatment with this medicine as it can cause weight gain.
Talk to your doctor if you notice sudden mood changes or develop suicidal thoughts.
Do not stop taking the medication suddenly without talking to your doctor as it may increase the seizure frequency.

Safety advice

Alcohol

UNSAFE

Do not drink alcohol while you are taking this medicine. TOPirol 50 Tablet may cause excessive drowsiness when taken with alcohol.

Pregnancy

UNSAFE

TOPirol 50 Tablet is highly unsafe during pregnancy. It can cause serious harm to the unborn baby, including birth defects and pregnancy loss. Do not use this medicine if you are pregnant or planning to become pregnant.

Breast feeding

CONSULT YOUR DOCTOR

TOPirol 50 Tablet may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.

Driving

UNSAFE

TOPirol 50 Tablet may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Kidney

CAUTION

TOPirol 50 Tablet should be used with caution in patients with kidney disease. Dose adjustment may be needed.

Liver

CAUTION

TOPirol 50 Tablet should be used with caution in patients with severe liver disease. Dose adjustment may be needed.

Interaction with drugs

Taking TOPirol with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Severe

Ulipristal acetate (Oral Route)

Do not consume Ulipristal acetate with Topiramate. If Ulipristal acetate is essential, ensure a gap of At least 4 weeks after discontinuing Topiramate. Please consult your doctor.

Moderate

Imatinib mesylate (Oral Route)

Do not consume Imatinib mesylate with Topiramate. If concurrent use is essential, your doctor may monitor your treatment and adjust the doses as per the observations. Topiramate may reduce blood levels and efficacy of Imatinib mesylate.

Moderate

Orlistat (Oral Route)

Watch out for symptoms such as tremors. seizures or impaired coordination and consult your doctor if you experience them. Your doctor may consider separating the administration of Orlistat and Topiramate. Orlistat may reduce efficacy of Topiramate.

Moderate

Sevelamer (Oral Route)

To take Topiramate, ensure a gap of at least 1 hour before or 3 hours after taking Sevelamer. Your doctor may monitor your treatment and adjust the doses as per the observations.

Moderate

Lithium carbonate (Oral Route)

Talk to your doctor if you notice any unusual symptoms.

Frequently asked questions

For how long do I need to take TOPirol 50 Tablet?

The dose and duration of this medicine will depend on your doctor’s advice. TOPirol 50 Tablet does not cure your condition (seizures/migraine) but prevents them from occurring. So, you may have to keep taking it for months or years depending on improvement in your symptoms and side effects that may occur.

Is TOPirol 50 Tablet good for anxiety?

TOPirol 50 Tablet is not indicated for the treatment of anxiety. Please consult your doctor before taking the medicine.

What are the serious side effects of TOPirol 50 Tablet?

Serious side effects of TOPirol 50 Tablet are rare. The serious effects of TOPirol 50 Tablet may include glaucoma (difficulty in seeing, eye pain, and blurred vision), kidney stones (sharp pain in your sides or lower back), and metabolic acidosis (tiredness, loss of appetite, irregular and faint heartbeat). Other serious side effects of TOPirol 50 Tablet could be suicidal thoughts and insufficient sweating (some children taking TOPirol 50 Tablet may not sweat enough in hot weather, causing their body temperatures to rise).

I am taking valproic acid for fits. Will TOPirol 50 Tablet interfere with the working of valproic acid? Can this combination be taken?

TOPirol 50 Tablet does not interfere with the working of valproic acid, but it increases the risk of getting excess levels of ammonia in the blood (hyperammonemia). Increased levels of ammonia in the blood can be dangerous and may cause difficulty in thinking, remembering information, or solving problems. It may also decrease your alertness and make you feel very sleepy with low energy. Immediately inform your doctor if you notice these symptoms. It is important to know that, in rare cases, TOPirol 50 Tablet alone can cause hyperammonemia.

Can TOPirol 50 Tablet be used in children?

Yes, TOPirol 50 Tablet is used for seizures in children more than 2 years of age. However, because of the lack of any reports, this medicine is not recommended to be used in children for migraines.

Since I have started using TOPirol 50 Tablet people are saying that I have lost weight. Is it because of TOPirol 50 Tablet or something else for which I should get investigated?

It could be due to TOPirol 50 Tablet because TOPirol 50 Tablet commonly causes weight loss probably due to a decrease in appetite. If you still have any doubts, talk to your doctor who will advise you appropriately.

Fact Box

Chemical Class

Dioxolopyrans

Habit Forming

Therapeutic Class

NEURO CNS

Action Class

Sodium Channel Modulators- Antiepileptic drugs (AEDs)

References

Stahl SM, editor. Topiramate. In: Stahl's Essential Pschopharmacology: Prescriber's Guide. 5th ed. New York, New York: Cambridge University Press; 2014. pp. 669-73.
McNamara JO. Pharmacotherapy of the Epilepsies. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 601.
Porters RJ, Meldrum BS. Antiseizure Drugs. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 12.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1380-82.
Topiramate. High Wycombe, Bucks: Janssen-Cilag Ltd.; 1995 [revised 13 Dec. 2017]. [Accessed 22 Jan. 2019] (online) Available from:
Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Topiramate. [Updated 2020 Jan 20]. [Accessed 20 Feb. 2020] (online) Available from:
Topiramate. Gurabo, Puerto Rico: Janssen Ortho; 2012. [Accessed 18 Mar. 2019] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 19 Mar. 2019] (online) Available from:
Topiramate [Prescribing Information]. Titusville, NJ: Janssen Pharmaceuticals, Inc.; 2025. [Accessed 05 Jan. 2026] (online). Available from:

User feedback

Patients taking TOPirol 50 Tablet

Once A Day

100%

What are you using TOPirol Tablet for?

Migraine

65%

Others

22%

Epilepsy

13%

How much was the improvement?

Average

57%

Poor

31%

Excellent

12%

What were the side-effects while using TOPirol 50 Tablet?

Sleepiness

27%

Dizziness

27%

Paresthesia (tingling or pricking sensation)

20%

Fatigue

No Side Effect

How do you take TOPirol Tablet?

With food

86%

Empty stomach

14%

Please rate TOPirol 50 Tablet on price

Average

56%

Not Expensive

33%

Expensive

11%

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Sun Pharmaceutical Industries Ltd
Address: Khasra No. 1335-1340,Near EPIP- I, Vill - Bhatoli Kalan ,Baddi, Solan, Himachal Pradesh, 173205 || Plot no 107/108,Namli block , Ranipool, East Sikkim 737135

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver TOPirol 50 Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

Lab tests offered by us

Why we need a prescription?

Provide right medicines

Prescriptions are complex documents. We proof read and recheck at various steps to provide you the right medication in the correct form and dose

In accordance with the law

Most medicines cannot be sold without a valid prescription, as per the Drugs and Cosmetics Act, 1940 and Rules, 1945

TOPirol 50 Tablet

Save more with additional offers

Save more with additional offers

General Information

Contains

Marketer

Storage

Product introduction

Uses of TOPirol Tablet

Benefits of TOPirol Tablet

Side effects of TOPirol Tablet

How to use TOPirol Tablet

How TOPirol Tablet works

All substitutes for TOPirol 50 Tablet

TOPAmac 50mg Tablet

Topaz 50 Tablet

Nextop 50 Tablet

Leptomate 50 Tablet

Topamed 50mg Tablet

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Ulipristal acetate (Oral Route)

Imatinib mesylate (Oral Route)

Orlistat (Oral Route)

Sevelamer (Oral Route)

Lithium carbonate (Oral Route)

Frequently asked questions

For how long do I need to take TOPirol 50 Tablet?

Is TOPirol 50 Tablet good for anxiety?

What are the serious side effects of TOPirol 50 Tablet?

I am taking valproic acid for fits. Will TOPirol 50 Tablet interfere with the working of valproic acid? Can this combination be taken?

Can TOPirol 50 Tablet be used in children?

Since I have started using TOPirol 50 Tablet people are saying that I have lost weight. Is it because of TOPirol 50 Tablet or something else for which I should get investigated?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

References

User feedback

Patients taking TOPirol 50 Tablet

What are you using TOPirol Tablet for?

How much was the improvement?

What were the side-effects while using TOPirol 50 Tablet?

How do you take TOPirol Tablet?

Please rate TOPirol 50 Tablet on price

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

In case of any issues, contact us

Lab tests offered by us

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