Sorafenat Tablet

Sorafenib (200mg)

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Sorafenat Tablet belongs to the class of medicines known as tyrosine kinase inhibitors used in the treatment of liver cancer, kidney cancer, and thyroid cancer.

Written By Dr. Lipika Khurana, PGDHHM, BDS,
Reviewed By Dr. Mekhala Chandra, MD, MBBS,
Last updated on 25 Nov 2025 | 03:05 PM (IST)

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General Information

Contains

Sorafenib (200mg)

Marketer

Natco Pharma Ltd

Storage

Store below 30°C

The content is shown in English

Product introduction

Sorafenat Tablet should be taken on an empty stomach, but try to have it at the same time every day to get the most benefits. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.

Fatigue, nausea, loss of appetite, hair loss and diarrhea are some common side effects of this medicine. It might cause high blood pressure, so the doctor may ask you for a regular check-up of blood pressure. You must inform your doctor if you notice severe skin reaction such as skin rash, or any pain, swelling, and redness of your hands and feet.

Before taking it, tell your doctor if you have heart disease, liver, or kidney problems or high blood pressure. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.

Uses of Sorafenat Tablet

Benefits of Sorafenat Tablet

Thyroid cancer
Thyroid is a butterfly-shaped gland located at the base of your neck. Your thyroid produces hormones that regulate your heart rate, blood pressure, body temperature and weight. Thyroid cancer occurs in the cells of the thyroid and it might not cause any symptoms at first. Sorafenat Tablet restricts the oxygen supply of the cancer cells and stops its growth as well as further spread. It is a potent and very toxic medicine and you should discuss the risks and benefits with your doctor. You should avoid drinking alcohol or smoking while having this treatment and drink plenty of water to stay hydrated.

Side effects of Sorafenat Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Sorafenat

Fatigue
Nausea
Loss of appetite
Diarrhea
Abdominal pain
Hair loss
Weight loss
Rash
Painful blisters on hands and feet

How to use Sorafenat Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Sorafenat Tablet is to be taken on an empty stomach.

How Sorafenat Tablet works

Sorafenat Tablet is an anti-cancer medication. It works by blocking the action of the abnormal protein that signals cancer cells to multiply. This helps to stop or slow the spread of cancer cells.

All substitutes for Sorafenat Tablet

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

Sorafenat Tablet is used in the treatment of liver, kidney, and thyroid cancer.
Take it without food, or with a low fat meal and a full glass of water.
Take it at the same time everyday to maintain consistent levels in your body.
Women who could get pregnant should use a reliable method of contraception to prevent pregnancy while taking this medicine.
Your doctor may regularly monitor your blood pressure while you are taking this medicine.
Inform your doctor if you get a skin rash, or any pain, swelling, and redness of your hands and feet while you are taking this medicine.
Do not change the dose or discontinue use without consulting your doctor.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Sorafenat Tablet. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

Sorafenat Tablet is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.

Breast feeding

UNSAFE

Sorafenat Tablet is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

Driving

SAFE

Sorafenat Tablet does not usually affect your ability to drive.

Kidney

SAFE IF PRESCRIBED

Sorafenat Tablet is safe to use in patients with kidney disease. No dose adjustment is recommended.
Regular monitoring of blood tests may be advised while you are taking this medicine.

Liver

CAUTION

Sorafenat Tablet should be used with caution in patients with severe liver disease. Dose adjustment may be needed.

Interaction with drugs

Taking Sorafenat with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Life-threatening

Ranolazine (Oral Route)

Do not consume Ranolazine with Sorafenib.

Life-threatening

Sildenafil (Oral Route)

Do not consume Sildenafil with Sorafenib.

Life-threatening

Amiodarone (Oral Route)

Do not consume Amiodarone with Sorafenib.

Life-threatening

Escitalopram Oxalate (Oral Route)

Do not consume Escitalopram Oxalate with Sorafenib.

Life-threatening

Pimozide (Oral Route)

Do not consume Pimozide with Sorafenib.

Frequently asked questions

How is Sorafenat Tablet administered?

Sorafenat Tablet is an oral medicine and you should take it exactly as per your doctor’s advice. It can be taken without food or with low to moderate fat meal. It should not be taken with high-fat meal which will make Sorafenat Tablet less effective. If you are taking high-fat meal, take Sorafenib 1 hour before or two hours after high-fat meal.

For how long do I need to take Sorafenat Tablet?

If Sorafenat Tablet suits you well, then you should continue taking it for the duration suggested by the doctor. However, if you experience any side effect that bothers you, talk to your doctor immediately.

Do I need to take a treatment along with Sorafenat Tablet for it to work?

Sorafenat Tablet is used as a monotherapy, that is, it is a medicine which is used alone rather than in combination with other treatments like radiotherapy or chemotherapy.

How do I know if I am responding to Sorafenat Tablet?

While receiving treatment with Sorafenat Tablet, your doctor will most likely recommend regular scans to monitor the size of the tumor. You may also need to get regular blood tests to see if the deranged liver or kidney functions have improved or not.

What are the serious side effects that can occur while taking Sorafenat Tablet?

The possible serious side effects that may occur (not in everyone) include heart attack and heart failure, increased risk of bleeding, high blood pressure, skin problems and wound healing problems. Some other side effects which get highlighted when you go through various tests are decreased blood flow to the heart, swelling of the liver, an opening in the wall of stomach or intestines (perforation), changes in electrical activity of the heart (QT prolongation) and changes in thyroid hormone levels.

Does Sorafenat Tablet affect blood sugar levels?

Yes, Sorafenat Tablet can cause a decrease in the blood sugar levels. In fact, the levels can decrease to the extent that the patient may faint. So, it is important that the patients having diabetes check their blood sugar levels regularly. Additionally, you should also consult the doctor if the dose of anti-diabetic medicines needs to be adjusted.

I have developed redness and pain in my palms and soles ever since I started using Sorafenat Tablet. My skin is also coming off. Is this dangerous? What should I do?

It seems you have developed hand and foot skin reaction due to Sorafenat Tablet. Consult your doctor who will either interrupt your therapy for sometime or change your dose. He might also suggest some cream or lotion to treat the problem. If the problem is severe, consult a skin doctor.

Fact Box

Chemical Class

Diarylethers

Habit Forming

Therapeutic Class

ANTI NEOPLASTICS

Action Class

Tyrosine Kinase Inhibitors (TKIs)

Related lab tests

Alpha-fetoprotein (AFP) L3 Fraction

Complete Blood Count

Thyroid Profile Free

References

Chabner BA, Barnes J, Neal J, et al. Targeted Therapies: Tyrosine Kinase Inhibitors, Monoclonal Antibodies, and Cytokines. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 1740.
Chu E, Sartorelli AC. Cancer Chemotherapy. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 955.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1274-75.
Sorafenib. Emeryville, California: Onyx Pharmaceuticals, Inc.; 2005 [revised Oct. 2010]. [Accessed 24 Jan. 2019] (online) Available from:
Sorafenib tosilate. Reading, Berkshire: Bayer Plc.; 2006 [revised Jun. 2018]. [Accessed 27 Mar. 2019] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 27 Mar. 2019] (online) Available from:

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Natco Pharma Ltd
Address: Natco House, Road No.2, Banjara Hills, Hyderabad-500 034, India

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Sorafenat Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

Lab tests offered by us

Why we need a prescription?

Sorafenat Tablet

Save more with additional offers

Save more with additional offers

General Information

Contains

Marketer

Storage

Product introduction

Uses of Sorafenat Tablet

Benefits of Sorafenat Tablet

Side effects of Sorafenat Tablet

How to use Sorafenat Tablet

How Sorafenat Tablet works

All substitutes for Sorafenat Tablet

Sorafenat 200mg Tablet

Nexavar 200mg Tablet

Soranib Tablet

SORATIb 200mg Tablet

Cadsonib Tablet

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Ranolazine (Oral Route)

Sildenafil (Oral Route)

Amiodarone (Oral Route)

Escitalopram Oxalate (Oral Route)

Pimozide (Oral Route)

Frequently asked questions

How is Sorafenat Tablet administered?

For how long do I need to take Sorafenat Tablet?

Do I need to take a treatment along with Sorafenat Tablet for it to work?

How do I know if I am responding to Sorafenat Tablet?

What are the serious side effects that can occur while taking Sorafenat Tablet?

Does Sorafenat Tablet affect blood sugar levels?

I have developed redness and pain in my palms and soles ever since I started using Sorafenat Tablet. My skin is also coming off. Is this dangerous? What should I do?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

Related lab tests

Alpha-fetoprotein (AFP) L3 Fraction

Complete Blood Count

Thyroid Profile Free

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

In case of any issues, contact us

Lab tests offered by us

Related/Popular tests