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Sorafenib is used in the treatment of liver cancer (hepatocellular carcinoma), advanced stage kidney cancer (advanced renal cell carcinoma) and thyroid cancer (differentiated thyroid carcinoma) when standard therapy has failed or is considered unsuitable.

How it works

Sorafenib belongs to the class of drugs called multikinase inhibitors. It slows down the rate of growth of cancer cells by blocking the action of an abnormal protein that signals cancer cells to multiply. It cuts down the blood supply to the cancer cells and stops their growth and proliferation.

Common side effects



Expert advice

  • Inform the doctor if you are suffering from high blood pressure, bleeding problems, chest pain, heart problems (prolongation of QT interval), kidney problems other than kidney cancer, or liver disease; if you are going to have a surgery or have been recently operated upon.
  • Seek immediate medical attention if you experience chest pain, severe dizziness, fainting, sweating or shortness of breath, blood in your urine or stools, abnormal vaginal bleeding, severe stomach pain, coughing up blood, or any bleeding that will not stop while receiving treatment with Sorafenib.
  • Tell your doctor if you are or planning to become pregnant or are breastfeeding, sorafenib may decrease fertility in men and women.
  • You may need frequent monitoring of fluid balance and electrolytes if you are at risk of renal dysfunction; monitoring of blood calcium levels and thyroid hormones if you are suffering from thyroid cancer.

Frequently asked questions


Q. Is sorafenib effective in chemotherapy?
Sorafenib is effective in chemotherapy of liver, kidney and thyroid cancer.
Q. Is sorafenib cytotoxic?
Sorafenib is a cytotoxic agent.
Q. How is sorafenib taken/administered?
Sorafenib is administered orally in the form of two tablets of 200 mg twice a day (total daily dose of 800 mg) on empty stomach at least 1 hour before or 2 hours after eating.
Q. What does sorafenib target?
Sorafenib targets the cancer cells to stop their growth and proliferation.

Content on this page was last updated on 30 September, 2016, by Dr. Varun Gupta (MD Pharmacology)