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    Information about Ranolazine

    Ranolazine uses

    Ranolazine is used to prevent Angina (heart-related chest pain).

    How ranolazine works

    Ranolazine is an anti-anginal medication. It works by decreasing the oxygen requirement of the heart by relaxing heart muscle.

    Common side effects of ranolazine

    Nausea, Vomiting, Headache, Dizziness, Constipation, Weakness
    Content Details
    Written By
    Dr. Betina Chandolia
    MDS, BDS
    Reviewed By
    Dr. Lalit Kanodia
    MD (Pharmacology), MBBS
    Last updated on:
    27 Dec 2019 | 01:08 PM (IST)
    Want to know more?
    Read Our Editorial Policy

    Available Medicine for Ranolazine

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      3 variant(s)
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      2 variant(s)
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      Lupin Ltd
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      Intas Pharmaceuticals Ltd
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      2 variant(s)
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      1 variant(s)
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      1 variant(s)

    Expert advice for Ranolazine

    • It should be taken with food to avoid stomach upset.
    • It improves HbA1c and blood sugar levels in diabetes patients.
    • It may cause dizziness or sleepiness. Do not drive or do anything requiring concentration until you know how it affects you.
    • Notify your doctor if you are taking any other medications along with Ranolazine
    • It may produce changes in the ECG (QTc interval prolongation). It is recommended to get an ECG done within 1 to 2 weeks of starting the medication.

    Frequently asked questions for Ranolazine


    Q. What are the serious side effects of Ranolazine?

    Ranolazine may cause changes in electrical activity of heart which is known as QT prolongation. Your doctor may get regular tests done to check the electrical activity of your heart. Tell your doctor right away if you feel faint, lightheaded or if your heart starts beating irregularly or fast, as these may be symptoms of QT prolongation. Ranolazine may also cause kidney failure in patients who already have kidney problems. Therefore, your doctor may need to do tests to check how your kidneys are working.

    Q. I started taking Ranolazine about a week ago. Now I have noticed that my urine has become very dark though I am taking plenty of fluids. Is there anything to worry about?

    Urine discoloration could be because of Ranolazine. You need not worry if you do not have any other symptoms. However, if it still bothers you, you can talk to your doctor who will advise you further.

    Q. In case I accidentally take excess of Ranolazine, what will happen?

    Excess of Ranolazine can cause nausea, vomiting, lightheadedness, double vision, tiredness, severe tremor, confusion, hallucinations, difficulty in speaking and walking and you can even faint. If you have taken excess of Ranolazine by mistake, call your doctor right away or seek emergency medical care in a nearby hospital.

    Q. Is it safe to take Ranolazine if I am already taking metoprolol?

    Yes, it is safe to take the Ranolazine and Metoprolol together. Ranolazine has minimal effect on blood pressure in patients of angina.

    Q. I am a diabetic and am taking metformin. My doctor has prescribed Ranolazine, is it safe to take both together?

    If you are taking metformin along with Ranolazine, you have to be careful since Ranolazine may increase the levels of metformin in the body which can lead to metformin toxicity. Talk to your doctor who will modify the dose of metformin.

    Q. I have been taking simvastatin to keep my cholesterol levels in check. Can I take Ranolazine with it?

    It is recommended not to take simvastatin and Ranolazine together because it may cause simvastatin toxicity which may lead to symptoms like muscle weakness and soreness, fatigue, decreased urination, etc. Let your doctor know that you are already taking simvastatin. If it is still necessary to take, then take it exactly as advised by the doctor.

    Content on this page was last updated on 27 December, 2019, by Dr. Varun Gupta (MD Pharmacology)