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Ranolazine

Information

Uses

Ranolazine is used to prevent angina
It does not stop angina attacks that have already started.

How it works

Ranolazine decreases the oxygen requirement of the heart by relaxing heart muscle. This helps to prevent angina.

Common side effects

Nausea, Vomiting, Headache, Dizziness, Constipation, Weakness

Available Medicine

  • ₹100 to ₹170
    Sun Pharmaceutical Industries Ltd
    3 variant(s)
  • ₹104 to ₹178
    Torrent Pharmaceuticals Ltd
    2 variant(s)
  • ₹108 to ₹156
    Lupin Ltd
    4 variant(s)
  • ₹168 to ₹169
    Unichem Laboratories Ltd
    2 variant(s)
  • ₹81 to ₹133
    MSN Laboratories
    2 variant(s)
  • ₹118
    Micro Labs Ltd
    1 variant(s)
  • ₹97
    Intas Pharmaceuticals Ltd
    1 variant(s)
  • ₹86
    Macleods Pharmaceuticals Pvt Ltd
    1 variant(s)
  • ₹120
    Zydus Cadila
    1 variant(s)
  • ₹75
    Glaxo SmithKline Pharmaceuticals Ltd
    1 variant(s)

Expert advice

  • The Ranolazine may cause dizziness and lightheadedness. To avoid this, get up slowly after sitting or lying down. 
  • Avoid driving if you feel dizzy after consuming Ranolazine.
  • Notify your doctor immediately if you are or are planning to become pregnant during the administration of this medicine.
  • Do not breast-feed while taking Ranolazine.
  • Inform your doctor if you have ever been diagnosed with kidney or liver problems.
  • Inform your doctor if you have ever had an abnormal ECG.
  • Inform your doctor if you are taking certain medications to treat bacterial or fungal infections. Your doctor may adjust the dose of Ranolazine.

Frequently asked questions

Ranolazine

Q. What is Ranolazine extended-release tablet?
Ranolazine extended release means the pill is formulated in such a manner that the drug is released slowly over time. This has the advantage of taking pills less often and also means that there may be fewer side effects as the levels of the drug in the body are more consistent.
Q. Do Ranolazine and trimetazidine act in the same way?
No. Both Ranolazine and Trimetazidine are used for the treatment of angina but they have different mechanisms. Trimetazidine improves glucose utilization of heart cells through inhibition of fatty acid metabolism. Ranolazine acts by blocking sodium current, reducing calcium overload and heart wall stress, leading to decreases oxygen requirement of the heart.
Q. Does Ranolazine decrease mortality?
No, Ranolazine does not decrease mortality.
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Q. What if Ranolazine used by patients with coronary artery disease?
Coronary Artery Disease(CAD) or Ischemic Heart Disease (IHD) includes angina & heart attack. Ranolazine does not reduce the risk of death or recurrent heart attacks in patients, but it improves angina symptoms.
Q. Can I use rivaroxaban with Ranolazine?
If you have kidney disease, you should inform your doctor before using rivaroxaban together with Ranolazine. Combining these medications can increase the blood levels of rivaroxaban and increase the risk of serious bleeding complications. You may need a dose adjustment.
Q. Can I take Ranolazine for type 2 diabetes?
No. Ranolazine is not used in the treatment of type 2 diabetes. It is indicated for the treatment of angina.
Q. What is the effect of Ranolazine in patients with coronary artery disease?
Ranolazine has been shown to improve exercise duration, decreases in the number of angina attacks per week and decrease in consumption of short-acting nitroglycerin.
Q. Can I take Ranolazine with quetiapine?
No. Using quetiapine with Ranolazine can increase the risk of an irregular heart rhythm that may be serious and potentially life-threatening.
Q. Is Ranolazine good for the heart?
It has been shown to improve exercise-induced chest pain and severity of angina.
Q. Are any alternatives to Ranolazine?
Ivabradine, nicorandil, and trimetazidine are other alternatives to Ranolazine that can be used for effective symptom control of anginal symptoms.
Q. Can I take Ranolazine with atorvastatin?
No. Ranolazine may significantly increase the blood levels of atorvastatin. This can increase the risk of side effects such as liver damage and the breakdown of skeletal muscle tissue. In some cases, this can cause kidney damage and even death.
Q. Can we use Ranolazine for the treatment of atrial fibrillation?
Ranolazine is an anti-angina drug, it may also be used in patients with Atrial Fibrillation(AF). Ranolazine has anti-AF efficacy, both alone or in combination with other drugs such as amiodarone.
Q. Is Ranolazine a beta blocker?
No. Ranolazine is not a beta blocker. It acts by blocking sodium current, reducing calcium overload and heart wall stress, leading to decreases oxygen requirement of the heart.
Q. Can I take Ranolazine with haloperidol?
No. Using haloperidol with Ranolazine can increase the risk of an irregular heart rhythm that may be serious and potentially life-threatening.
Q. Is Ranolazine effective in arrhythmia?
Multiple studies have evaluated the role of Ranolazine in prevention and management of atrial fibrillation (a type of arrhythmia), with ongoing studies on its role in ventricular arrhythmias (a type of arrhythmia).
Q. Is Ranolazine a blood thinner?
No, Ranolazine is not a blood thinner.
Q. What are the contraindications to Ranolazine?
Ranolazine is contraindicated in patients with liver damage (cirrhosis). It should not be given with enzyme inhibitors like ketoconazole, itraconazole, clarithromycin, nefazodone, nelfinavir, ritonavir, indinavir, saquinavir and enzyme inducers like carbamazepine, phenobarbital, phenytoin, rifampin.
Q. Can Ranolazine use for the treatment of diastolic heart failure?
Ranolazine has shown improvement in diastolic heart failure in experimental studies on animals, but studies in humans are ongoing.

Content on this page was last updated on 15 May, 2017, by Dr. Varun Gupta (MD Pharmacology)