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    Ranolazine

    Information about Ranolazine

    Ranolazine uses

    Ranolazine is used to prevent chest pain (Angina)
    It treats angina that keeps coming back (chronic angina). It may be used with medicines that are used for heart problems and blood pressure control.

    How ranolazine works

    Ranolazine is an anti-anginal medication. It works by decreasing the oxygen requirement of the heart by relaxing heart muscle.

    Common side effects of ranolazine

    Nausea, Vomiting, Headache, Dizziness, Constipation, Weakness

    Available Medicine for Ranolazine

    • ₹107 to ₹170
      Sun Pharmaceutical Industries Ltd
      3 variant(s)
    • ₹114 to ₹178
      Torrent Pharmaceuticals Ltd
      2 variant(s)
    • ₹108 to ₹156
      Lupin Ltd
      2 variant(s)
    • ₹168 to ₹169
      Unichem Laboratories Ltd
      2 variant(s)
    • ₹81 to ₹133
      MSN Laboratories
      2 variant(s)
    • ₹97
      Intas Pharmaceuticals Ltd
      1 variant(s)
    • ₹118
      Micro Labs Ltd
      1 variant(s)
    • ₹94
      Macleods Pharmaceuticals Pvt Ltd
      1 variant(s)
    • ₹120
      Zydus Cadila
      1 variant(s)
    • ₹75
      Glaxo SmithKline Pharmaceuticals Ltd
      1 variant(s)

    Expert advice for Ranolazine

    • Ranolazine may cause dizziness and lightheadedness. To avoid this, get up slowly after sitting or lying down.
    • Avoid driving if you feel dizzy after consuming Ranolazine.
    • Notify your doctor immediately if you are or are planning to become pregnant during the administration of this medicine.
    • Do not breast-feed while taking Ranolazine.
    • Inform your doctor if you have ever been diagnosed with kidney or liver problems.
    • Inform your doctor if you have ever had an abnormal ECG.
    • Inform your doctor if you are taking certain medications to treat bacterial or fungal infections. Your doctor may adjust the dose of Ranolazine.

    Frequently asked questions for Ranolazine

    Ranolazine

    Q. What is Ranolazine extended-release(ER) tablet?
    Ranolazine extended release (ER) means the pill is formulated in such a manner that the drug is released slowly over time and blood levels of a drug are more consistent. This has the advantage of taking fewer pills and also with a lesser gastrointestinal side effect.
    Q. Do Ranolazine and trimetazidine act in the same way?
    No. Both Ranolazine and trimetazidine are used for the treatment of angina but they work by a different mechanism. Ranolazine works by blocking late sodium current channel during ischemia and thereby lessens the intracellular sodium and calcium overload. This relaxes heart muscles and decreases the oxygen requirement. This helps to prevent angina. Trimetazidine works by improves glucose utilisation of heart cells through inhibition of fatty acid metabolism.
    Q. What is the effect of Ranolazine in patients with coronary artery disease?
    The researcher has studied Ranolazine in patients with non-ST-elevation coronary artery disease. It did not reduce the risk of death or recurrent heart attacks in patients, but it improves angina symptoms. It is approved for use in angina.
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    Q. Can I use rivaroxaban with Ranolazine?
    Yes. Combining these medications can increase the blood levels of rivaroxaban and increase the risk of serious bleeding complications. You may need a dose adjustment. If you have kidney disease, you should inform your doctor before using rivaroxaban together with Ranolazine.
    Q. Can I take Ranolazine for type 2 diabetes?
    No. Ranolazine is not approved for treatment of type 2 diabetes. Study have demonstrated its ability to decrease HbA1c (glycosylated haemoglobin) in patients with or without diabetes. This property may be useful in the treatment of patients having diabetes mellitus and angina.
    Q. Can I take Ranolazine with quetiapine?
    No. Using Quetiapine with Ranolazine can increase the risk of an irregular heart rhythm that may be serious and potentially life-threatening.
    Q. Is Ranolazine good for the heart?
    Ranolazine is used in a disease of the heart known as angina. It has been shown to improve exercise-induced chest pain and severity of angina.
    Q. Are any alternatives to Ranolazine?
    Yes, there are alternative to Ranolazine e.g.Ivabradine, nicorandil and trimetazidine for effective control of anginal symptoms.
    Q. Can I take Ranolazine with atorvastatin?
    Yes. Ranolazine may significantly increase the blood levels of atorvastatin. This can increase the risk of side effects such as liver damage and the breakdown of skeletal muscle tissue. It can be used with atorvastatin but with dose limitation (atorvastatin) and appropriate clinical monitoring. In some cases, this can cause kidney damage and even death.
    Q. Can I use Ranolazine for the treatment of atrial fibrillation?
    No. Ranolazine is not approved for treatment of atrial fibrillation (AF). The researcher has demonstrated, its usefulness in patients with Atrial Fibrillation(AF) and in nonsustained ventricular tachycardia (VT) in the experimental model.
    Q. Is Ranolazine a beta blocker?
    No, Ranolazine is not a beta blocker. It is used in the treatment of angina.
    Q. Can I take Ranolazine with haloperidol?
    No. Ranolazine should not be used with haloperidol. It may increase the risk of an irregular heart rhythm that may be serious and potentially life-threatening.
    Q. Is Ranolazine effective in arrhythmia?
    No. Ranolazine is not approved for use in any of arrhythmia. The researcher has demonstrated, its usefulness in patients with Atrial Fibrillation(AF) and in nonsustained ventricular tachycardia (VT) in the experimental model.
    Q. What are the contraindications to Ranolazine?
    Ranolazine is contraindicated in patients with liver damage (cirrhosis). It should not be given with medicine like ketoconazole, itraconazole, clarithromycin, nefazodone, nelfinavir, ritonavir, indinavir, saquinavir, carbamazepine, phenobarbital, phenytoin, rifampin.
    Q. Can I use Ranolazine for the treatment of diastolic heart failure?
    No. Ranolazine is not used in the treatment of diastolic heart failure. It is used in the treatment of angina.

    Content on this page was last updated on 08 November, 2017, by Dr. Varun Gupta (MD Pharmacology)