Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Milpran 50mg Tablet may be taken with or without food, but it is better to take it at a fixed time.
Milpran 50mg Tablet works by increasing the levels of chemical messengers (serotonin and noradrenaline), natural substances in the brain that help maintain mental balance and stop the movement of pain signals in the brain.
You may have to wait for 2 to 4 weeks to get the full effect.
If your doctor asks you to stop Milpran 50mg Tablet, you should not discontinue it abruptly. Many patients tolerate decreasing 50% dose every 3 days however if the withdrawal symptoms emerge during tapering it would require more gradual tapering over few weeks.
Inform your doctor if you have ever been diagnosed with any heart problems (heart attack, heart failure, slow or irregular heart rate).
Inform your doctor if you have ever been diagnosed with kidney or liver problems.
It can cause a sensation of restlessness or an inability to sit or stand still. This is most likely to occur within the first few weeks of treatment. You should tell your doctor if this happens to you.
It may be more effective in some patients with depression who fails to respond to selective serotonin receptor inhibitors (SSRI) e.g. Fluoxetine.
Milpran 50mg Tablet may cause excessive drowsiness and calmness with alcohol.
WEIGH RISKS VS BENEFITS
Milpran 50mg Tablet may be unsafe to use during pregnancy. Animal studies have shown adverse effects on the foetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor.
Milpran 50mg Tablet is probably unsafe to use during lactation.
Limited human data suggest that the drug could represent a significant risk to the baby.
Do not drive unless you are feeling well. As Milpran 50mg Tablet may impair your thinking or reactions and this may affect your ability to drive.
Milpran 50mg Tablet should be used with caution in patients with kidney disease. Dose adjustment of Milpran 50mg Tablet may be needed. Please consult your doctor.
Milpran 50mg Tablet is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Milpran 50mg Tablet may not be needed in these patients. Please consult your doctor. Caution is advised in patients with the severe liver disease.
If you miss a dose of Milpran 50mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.