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Amitriptyline is used in the treatment of depression and neuropathic pain.

How it works

Amitriptyline increases the levels of chemical messengers in the brain that help in regulating the mood and treat depression.

Common side effects

Sleepiness, Blurred vision, Increased heart rate, Dry mouth, Constipation, Weight gain, Difficulty in urination, Orthostatic hypotension (sudden lowering of blood pressure on standing)

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Expert advice

  • Do not consume grapefruit juice.
  • Do not suddenly stop taking your medicine.
  • Amitriptyline can make you dizzy or sleepy. So avoid driving or performing activities that require mental alertness. 
  • Avoid alcohol intake.
  • Do not take this drug if you are consuming antidepressants (monoamine oxidase inhibitors) or have been taking them within the previous two weeks.

Frequently asked questions



Is amitriptyline/Tryptomer safe?
Amitriptyline is safe if used at prescribed doses for the prescribed duration as advised by your doctor


What is amitriptyline/Amitone 10/Amitone plus/ Tryptomer/Tryptomer plus used for?
Amitriptyline/amitone 10/amitone plus/ tryptomer/tryptomer plus is used in the treatment of depression and nocturnal bed wetting (enuresis) in children


Is amitriptyline a benzodiazepine/MAOI/opioid/antibiotic/steroid?
No, Amitriptyline belongs to class of medication called as tricyclic antidepressant

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Is amitriptyline like Xenan (diazepam)?
No, Xenan belongs to class of medication called as benzodiazepine


Is amitriptyline addictive?
No, Patients should follow the advice of the doctor regarding its use


Can I take amitriptyline/tryptomer for pain/insomnia/backache/migraine/headache/anxiety?
No, it is used to treatment of depression and nocturnal bed wetting (enuresis)


Can I take amitriptyline with Prozac/zopiclone/Xanan/naproxen/prednisolone/Benadryl/diazepam/trazadone/Flexeril?
Amitriptyline can interact with Prozac/Zopiclone/Xanan/diazepam/trazadone/flexeril. Please follow doctor's advice regarding its use


Does amitriptyline cause hair loss/ insomnia/constipation/weight gain: loss/fever/affect memory/vomiting/increased hunger/sleepiness?
Amitriptyline causes insomnia/constipation/weight gain/vomiting/increases huger. Always consult your doctor regarding possible side effects.

Content on this page was last updated on 12 April, 2017, by Dr. Varun Gupta (MD Pharmacology)