Information about Amitriptyline

Amitriptyline uses

Amitriptyline is used in the treatment of depression and neuropathic pain.
It is used in patients intolerant of or unresponsive to alternative treatment options for depression.

How amitriptyline works

Amitriptyline increases the levels of chemical messengers in the brain that help in regulating the mood and treat depression.

Common side effects of amitriptyline

Sleepiness, Blurred vision, Increased heart rate, Dry mouth, Constipation, Weight gain, Difficulty in urination, Orthostatic hypotension (sudden lowering of blood pressure on standing).

Available Medicine for Amitriptyline

  • ₹33 to ₹85
    Wockhardt Ltd
    5 variant(s)
  • ₹22 to ₹55
    Sun Pharmaceutical Industries Ltd
    4 variant(s)
  • ₹15 to ₹70
    Intas Pharmaceuticals Ltd
    4 variant(s)
  • ₹22 to ₹65
    Icon Life Sciences
    4 variant(s)
  • ₹22 to ₹51
    Lundbeck India Pvt Ltd
    3 variant(s)
  • ₹19 to ₹54
    Talent India
    3 variant(s)
  • ₹34 to ₹45
    Shine Pharmaceuticals Ltd
    3 variant(s)
  • ₹23 to ₹62
    Sterkem Pharma Pvt Ltd
    6 variant(s)
  • ₹22 to ₹109
    KC Laboratories
    4 variant(s)
  • ₹11 to ₹59
    Tas Med India Pvt Ltd
    6 variant(s)

Expert advice for Amitriptyline

  • The main dose should be taken at night as this drug may produce drowsiness or sleepiness.
  • It can take 4 to 6 weeks for Amitriptyline to start working.
  • You should continue the treatment for at least 6 months after you feel better to stop depression from coming back.
  • If your doctor asks you to stop Amitriptyline, you should reduce the dose slowly over 4 weeks. You should not discontinue it abruptly.
  • Avoid driving or operating machinery as it may decrease alertness.
  • Avoid consuming alcohol when taking the Amitriptyline, as it may cause excessive drowsiness and calmness.
  • The addiction/dependence potential of Amitriptyline is very less.
  • It may be extremely dangerous in overdose.

Frequently asked questions for Amitriptyline


Q. Is amitriptyline/Tryptomer safe?
Amitriptyline is safe if used at prescribed doses for the prescribed duration as advised by your doctor
Q. What is amitriptyline/Amitone 10/Amitone plus/ Tryptomer/Tryptomer plus used for?
Amitriptyline/amitone 10/amitone plus/ tryptomer/tryptomer plus is used in the treatment of depression and nocturnal bed wetting (enuresis) in children
Q. Is amitriptyline a benzodiazepine/MAOI/opioid/antibiotic/steroid?
No, Amitriptyline belongs to class of medication called as tricyclic antidepressant
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Q. Is amitriptyline like Xenan (diazepam)?
No, Xenan belongs to class of medication called as benzodiazepine
Q. Is amitriptyline addictive?
No, Patients should follow the advice of the doctor regarding its use
Q. Can I take amitriptyline/tryptomer for pain/insomnia/backache/migraine/headache/anxiety?
No, it is used to treatment of depression and nocturnal bed wetting (enuresis)
Q. Can I take amitriptyline with Prozac/zopiclone/Xanan/naproxen/prednisolone/Benadryl/diazepam/trazadone/Flexeril?
Amitriptyline can interact with Prozac/Zopiclone/Xanan/diazepam/trazadone/flexeril. Please follow doctor's advice regarding its use
Q. Does amitriptyline cause hair loss/ insomnia/constipation/weight gain: loss/fever/affect memory/vomiting/increased hunger/sleepiness?
Amitriptyline causes insomnia/constipation/weight gain/vomiting/increases huger. Always consult your doctor regarding possible side effects.
Q. Can I take Amitriptyline with Betahistine?
Amitriptyline has not been clinically studied when used along with Betahistine So there are no reports of any drug-drug interactions or harmful effects when these are used together.

Content on this page was last updated on 23 June, 2017, by Dr. Varun Gupta (MD Pharmacology)