Milnace 50 Tablet

Written By Dr. Lipika Khurana, PGDHHM, BDS

Reviewed By Dr. Sachin Gupta, MD Pharmacology, MBBS

Last updated on 09 Feb 2026 | 03:40 PM (IST)

Milnace 50 Tablet is a prescription medicine used in the treatment of fibromyalgia (a condition in which there are generalized pain and tenderness in the body) and depression. It works by increasing the level of chemical messengers (serotonin and noradrenaline), helping in faster recovery.

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General Information

Contains

Milnacipran (50mg)

Marketer

Torrent Pharmaceuticals Ltd

Storage

Store below 30°C

The content is shown in English

Product introduction

Milnace 50 Tablet may be taken with or without food. It is advised to take this medicine at a fixed time each day to maintain a consistent level in the blood. If you miss any doses, take it as soon as you remember. Do not skip any doses and finish the full course of treatment even if you feel better. This medication mustn't be stopped suddenly as it may worsen your symptoms.

Some common side effects of this medicine include nausea, vomiting, insomnia (difficulty sleeping), constipation, anxiety, decreased appetite, increased sweating, and sexual dysfunction. It even causes dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you. However, these side effects are temporary and usually resolve on their own in some time. Please consult your doctor if these do not subside or bother you.

Before taking Milnace 50 Tablet, inform your doctor if you have any problems with your kidneys, heart, liver, or have a history of seizures (epilepsy or fits). Inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or if you have any suicidal thoughts.

Uses of Milnace Tablet

Benefits of Milnace Tablet

Depression
Milnace 50 Tablet is used in depression to improve mood, restore emotional balance, and reduce symptoms like sadness, lack of interest, and low energy. It helps individuals feel more motivated and better able to engage in daily activities.

Fibromyalgia
Milnace 50 Tablet is used in fibromyalgia to help reduce widespread body pain and tenderness. It improves physical function, lessens fatigue, and supports better quality of life in people living with this chronic condition.

Side effects of Milnace Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Milnace

Nausea
Vomiting
Dizziness
Insomnia (difficulty in sleeping)
Constipation
Anxiety
Decreased appetite
Increased sweating
Sexual dysfunction

How to use Milnace Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Milnace 50 Tablet may be taken with or without food.

How Milnace Tablet works

Milnace 50 Tablet works by increasing the levels of chemical messengers (serotonin and noradrenaline), natural substances in the brain that help maintain mental balance and stop the movement of pain signals in the brain.

Quick tips

It may take 2 to 4 weeks for Milnace 50 Tablet to start working. Keep taking it as prescribed.
It may cause dizziness and sleepiness. Do not drive or do anything requiring concentration until you know how it affects you.
Avoid consuming alcohol when taking Milnace 50 Tablet as it may cause excessive drowsiness and increase the risk of liver damage.
It may cause a sensation of restlessness, especially when you first start taking it. Inform your doctor if this happens to you.
Talk to your doctor if you notice sudden mood changes or develop suicidal thoughts.
Do not stop taking the medication suddenly without talking to your doctor.
Milnace 50 Tablet helps in treating depression and anxiety.
It may also be used to treat nerve pain from diabetes and some other forms of chronic pain.
It may take 2 to 4 weeks for Milnace 50 Tablet to start working. Keep taking it as prescribed.
It may cause dizziness and sleepiness. Do not drive or do anything requiring concentration until you know how it affects you.
Avoid consuming alcohol when taking Milnace 50 Tablet as it may cause excessive drowsiness and increase the risk of liver damage.
It may cause an increase in blood pressure, especially during the first month of treatment. Monitor your blood pressure regularly.
It may cause a sensation of restlessness, especially when you first start taking it. Inform your doctor if this happens to you.
Talk to your doctor if you notice sudden mood changes or develop suicidal thoughts.
Do not stop taking the medication suddenly without talking to your doctor.

Safety advice

Alcohol

CAUTION

Alcohol should be used with caution while taking Milnace 50 Tablet.

Pregnancy

CONSULT YOUR DOCTOR

Milnace 50 Tablet is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.

Breast feeding

CONSULT YOUR DOCTOR

Milnace 50 Tablet may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.

Driving

UNSAFE

Milnace 50 Tablet may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
As Milnace 50 Tablet may impair your thinking or reactions and this may affect your ability to drive.

Kidney

CAUTION

Milnace 50 Tablet should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.

Liver

SAFE IF PRESCRIBED

Milnace 50 Tablet is probably safe to use in patients with liver disease. Limited data suggest dose adjustment may not be needed.
Caution is advised in patients with the severe liver disease.

Interaction with drugs

Taking Milnace with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Life-threatening

Moclobemide (Oral Route)

Do not consume Moclobemide with Milnacipran. If concurrent use is essential, please consult your doctor.

Life-threatening

Tranylcypromine (Oral Route)

Do not consume Tranylcypromine with Milnacipran. If Tranylcypromine is essential, ensure a gap of At least 5 to 7 days before starting and two weeks after discontinuing Milnacipran. Please consult your doctor.

Life-threatening

Selegiline (Oral Route)

Do not consume Selegiline with Milnacipran. If Selegiline is essential, ensure a gap of at least 2 weeks after discontinuing Milnacipran. Please consult your doctor.

Severe

Ziprasidone (Oral Route)

Watch out for symptoms such as tremors, fever, diarrhea or agitation and consult your doctor if you experience them. Your doctor may discontinue the medicines accordingly.

Severe

Amitriptyline (Oral Route)

Talk to your doctor if you notice any unusual symptoms. Your doctor may adjust the dose if required.

Frequently asked questions

Is Milnace 50 Tablet addictive?

Milnace 50 Tablet does not cause addiction

Is Milnace 50 Tablet narcotic?

Milnace 50 Tablet is not a narcotic

Is Milnace 50 Tablet a generic or a controlled substance?

Milnace 50 Tablet is a generic and not a controlled substance

Does Milnace 50 Tablet cause weight loss?

Milnace 50 Tablet may cause this side effect. Call your doctor if you experience any unusual problems during your treatment.

Fact Box

Chemical Class

Fenylpropylamine derivative

Habit Forming

Therapeutic Class

NEURO CNS

Action Class

Serotonin Norepinephrine Reuptake Inhibitors (SNRIs)

References

Stahl SM, editor. Milnacipran. In: Stahl's Essential Pschopharmacology: Prescriber's Guide. 5th ed. New York, New York: Cambridge University Press; 2014. pp. 435-39.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. p. 921.
Milnacipran. New York, New York: Forest Laboratories, Inc.; 2009 [revised Jan. 2009]. [Accessed 25 Mar 2019] (online) Available from:
Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Milnacipran. [Updated 2018 Oct 31]. Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 25 Mar. 2019] (online) Available from:

User feedback

Patients taking Milnace 50 Tablet

Once A Day

57%

Twice A Day

33%

Thrice A Day

Alternate Day

What are you using Milnace Tablet for?

Depression

100%

How much was the improvement?

Excellent

53%

Average

27%

Poor

20%

What were the side-effects while using Milnace 50 Tablet?

No Side Effect

75%

Vomiting

25%

How do you take Milnace Tablet?

With food

80%

With or without food

20%

Please rate Milnace 50 Tablet on price

Average

87%

Expensive

13%

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Torrent Pharmaceuticals Ltd
Address: Off. Ashram Road, Ahmedabad - 380 009., Gujarat, India

Vendor Details

Country of origin: India

Lab tests offered by us

Why we need a prescription?

Milnace 50 Tablet

Save more with additional offers

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General Information

Contains

Marketer

Storage

Product introduction

Uses of Milnace Tablet

Benefits of Milnace Tablet

Side effects of Milnace Tablet

How to use Milnace Tablet

How Milnace Tablet works

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Moclobemide (Oral Route)

Tranylcypromine (Oral Route)

Selegiline (Oral Route)

Ziprasidone (Oral Route)

Amitriptyline (Oral Route)

Frequently asked questions

Is Milnace 50 Tablet addictive?

Is Milnace 50 Tablet narcotic?

Is Milnace 50 Tablet a generic or a controlled substance?

Does Milnace 50 Tablet cause weight loss?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

References

User feedback

Patients taking Milnace 50 Tablet

What are you using Milnace Tablet for?

How much was the improvement?

What were the side-effects while using Milnace 50 Tablet?

How do you take Milnace Tablet?

Please rate Milnace 50 Tablet on price

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

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