Mela 5mg Tablet

Reviewed By Dr. Mekhala Chandra, MD, MBBS

Last updated on 10 Mar 2026 | 11:05 AM (IST)

Mela 5mg Tablet is a type of diuretic (water pill) medicine. This medicine reduces excess fluid levels in the body and is used to treat edema (fluid overload) associated with heart, liver, kidney, or lung disease. It is also used in the treatment of hypertension (high blood pressure).

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Mela 5mg Tablet

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Metolazone (5mg)

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General Information

Contains

Metolazone (5mg)

Marketer

RPG Life Sciences Ltd

Storage

Store below 30°C

The content is shown in English

Product introduction

Mela 5mg Tablet makes you lose excess water through urine. It may be used alone or in combination with other medicines. This medicine should be taken only during day time to avoid frequent urination at night. You must take this medicine in the dose and duration as advised by the doctor and never stop it abruptly without consulting the doctor.

Common side effects of this medicine include headache, nausea, blurred vision, and dizziness. Consult your doctor if these side effects bother you. Before taking this medicine, it is better to let your doctor know if you are suffering from any kidney or liver disease. Also, pregnant women and breastfeeding mothers should consult a doctor before taking it. You must inform the doctor about all the other medicines that you are taking apart from this medicine. Regular monitoring of kidney function and electrolytes is important while using this medicine.

Uses of Mela Tablet

Benefits of Mela Tablet

Hypertension (high blood pressure)
High blood pressure occurs when the force of blood against the artery walls remains high over time, increasing the risk of heart and blood vessel problems. Mela 5mg Tablet helps reduce excess salt and water in the body, which lowers blood volume and supports better blood pressure control. This helps reduce strain on the heart and lowers the risk of complications linked to uncontrolled blood pressure.

Heart Failure
Heart failure is a condition where the heart cannot pump blood efficiently, leading to fluid buildup in the body and lungs. Mela 5mg Tablet helps remove excess fluid, which can ease swelling and breathlessness. It reduces fluid overload, supports improved comfort, better daily functioning, and overall quality of life.

Treatment of Edema
Edema is caused by your body retaining too much water. Mela 5mg Tablet helps get rid of the extra water and electrolytes from your body by increasing the amount of urine produced. This enables your body to get rid of extra water thereby relieving symptoms such as shortness of breath and swelling in your arms, legs or abdomen. Therefore, you can carry out your daily activities more comfortably. Take it regularly and make appropriate lifestyle changes to get maximum benefits.

Side effects of Mela Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Mela

Headache
Nausea
Dizziness
Blurred vision
Lightheadedness

How to use Mela Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Mela 5mg Tablet may be taken with or without food.

How Mela Tablet works

Mela 5mg Tablet is a thiazide diuretic. It lowers blood pressure and fluid retention in edema by removing the extra water and certain electrolytes from the body. Over time it also works by relaxing blood vessels and improving blood flow.

All substitutes for Mela 5mg Tablet

For information purposes only. Consult a doctor before taking any medicine.

Metoz 5 Tablet

by Centaur Pharmaceuticals Pvt Ltd

₹32.7/tablet

295% costlier

Zytanix 5 Tablet

by Zydus Cadila

₹33.13/tablet

301% costlier

Quick tips

Take it in the morning with breakfast to avoid getting up at night to urinate.
It makes you feel dizzy. Avoid driving and attention requiring activity until you know how it affects you.
Avoid alcohol intake while taking Mela 5mg Tablet as it may increase the dizziness.
It may cause a sudden drop of sodium level in blood. Avoid low sodium diet while you are taking this medication.
Monitor your blood pressure after starting Mela 5mg Tablet, and notify your doctor if it does not lower down.
Notify your doctor if you experience dizziness, tiredness, or muscle weakness that does not go away.
Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.

Safety advice

Alcohol

CAUTION

Alcohol should be used with caution while taking Mela 5mg Tablet.

Pregnancy

CONSULT YOUR DOCTOR

Mela 5mg Tablet is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.

Breast feeding

CONSULT YOUR DOCTOR

Mela 5mg Tablet may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.

Driving

UNSAFE

Mela 5mg Tablet may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Kidney

CONSULT YOUR DOCTOR

There is limited data available on the use of Mela 5mg Tablet in patients with kidney disease. Please consult your doctor.

Liver

CAUTION

Mela 5mg Tablet should be used with caution in patients with liver disease. Dose adjustment may be needed.

Interaction with drugs

Taking Mela with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Severe

Lithium carbonate (Oral Route)

Do not consume Lithium carbonate with Metolazone. If concurrent use is essential, your doctor may regularly monitor Lithium carbonate and potassium levels. Watch out for symptoms such as impaired coordination, double vision, dizziness, or confusion, and consult your doctor if you experience them. They may adjust the dose of Lithium carbonate accordingly.

Moderate

Chloroquine (Oral Route)

Your doctor may monitor your potassium levels closely.

Moderate

Dexamethasone (Oral Route)

If concurrent use is essential, your doctor may monitor your potassium levels along with your overall treatment and adjust the doses as per the observations.

Moderate

Loperamide (Oral Route)

Your doctor may monitor your potassium levels closely.

Moderate

Azithromycin (Oral Route)

Your doctor may monitor your potassium levels closely.

Frequently asked questions

What is Mela 5mg Tablet used for?

Mela 5mg Tablet is used to help the body remove excess salt and water. It is prescribed for swelling (edema) caused by heart failure or kidney problems, including nephrotic syndrome, and can also be used to help control high blood pressure, either alone or with other blood pressure medicines.

Who should not take Mela 5mg Tablet?

Individuals should not take Mela 5mg Tablet if they cannot pass urine, have liver coma or pre-coma, or have had an allergic reaction to metolazone.

Can Mela 5mg Tablet cause serious electrolyte problems?

Yes, Mela 5mg Tablet can cause dangerously low sodium or potassium levels, sometimes very quickly after starting treatment. This can lead to weakness, muscle cramps, irregular heartbeat, confusion, or even life-threatening complications.

Does Mela 5mg Tablet affect potassium levels in the body?

Mela 5mg Tablet can lower potassium levels, especially in people on high doses, those with rapid fluid loss, liver disease, or those taking corticosteroids. Low potassium can cause muscle weakness and dangerous heart rhythm problems.

Does Mela 5mg Tablet affect blood sugar levels?

Mela 5mg Tablet may raise blood sugar levels and cause sugar to appear in the urine. People with diabetes, or those at risk, should have their blood glucose monitored regularly while taking this medicine.

Can Mela 5mg Tablet trigger gout?

Yes, Mela 5mg Tablet can increase uric acid levels in the blood, which may lead to gout attacks, even in people who have never had gout before.

Is Mela 5mg Tablet safe for people with kidney problems?

Mela 5mg Tablet should be used with caution in people with severely reduced kidney function, as the medicine is mainly removed from the body by the kidneys and may build up to unsafe levels.

Can Mela 5mg Tablet cause dizziness or low blood pressure?

Yes, Mela 5mg Tablet can lower blood pressure and sometimes cause dizziness, especially when standing up suddenly. This effect can be stronger if you drink alcohol or take other blood pressure medicines.

Does Mela 5mg Tablet affect calcium levels in the body?

Mela 5mg Tablet can sometimes cause high calcium levels, especially in people taking high doses of vitamin D or with certain bone conditions. It should be stopped before tests for parathyroid gland function.

Fact Box

Chemical Class

Quinazolines

Habit Forming

Therapeutic Class

CARDIAC

Action Class

Thiazide Diuretics

Related lab tests

Kidney Function Test

References

Opie LH, Victor RG, Kaplan NM. Diuretics. In: Opie LH, Gersh BJ, editors. Drugs for the Heart. 8th ed. Philadelphia, Pennsylvania: Elsevier Saunders; 2013. pp. 103-104.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. p. 903.
Metolazone tablets. Rochester, New York: Celltech Pharmaceuticals, Inc.; 2001. [Accessed 19 Mar. 2019] (online) Available from:
Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Metolazone. [Updated 2019 Feb 7]. [Accessed 19 Feb. 2020] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 19 Mar. 2019] (online) Available from:
Metolazone [Drug Label]. Philadelphia, PA: Lannett Company, Inc.; 2019. [Accessed 25 Jul. 2024] (online) Available from:
Metolazone [Drug Label]. Princeton, NJ: Sandoz Pvt. Ltd.; 2022. [Accessed 05 Jan. 2026] (online). Available from:
Metolazone [Drug Label]. 2021. [Accessed 05 Jan. 2026] (online). Available from:

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: RPG Life Sciences Ltd
Address: 463, 4 th Floor, RPG HOUSE, Dr. Annie Besant Road, Worli, Mumbai – 400 030. Maharashtra, INDIA

Vendor Details

Country of origin: India

Lab tests offered by us

Why we need a prescription?

Provide right medicines

Prescriptions are complex documents. We proof read and recheck at various steps to provide you the right medication in the correct form and dose

In accordance with the law

Most medicines cannot be sold without a valid prescription, as per the Drugs and Cosmetics Act, 1940 and Rules, 1945

Mela 5mg Tablet

Save more with additional offers

Save more with additional offers

General Information

Contains

Marketer

Storage

Product introduction

Uses of Mela Tablet

Benefits of Mela Tablet

Side effects of Mela Tablet

How to use Mela Tablet

How Mela Tablet works

All substitutes for Mela 5mg Tablet

Metoz 5 Tablet

Zytanix 5 Tablet

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Lithium carbonate (Oral Route)

Chloroquine (Oral Route)

Dexamethasone (Oral Route)

Loperamide (Oral Route)

Azithromycin (Oral Route)

Frequently asked questions

What is Mela 5mg Tablet used for?

Who should not take Mela 5mg Tablet?

Can Mela 5mg Tablet cause serious electrolyte problems?

Does Mela 5mg Tablet affect potassium levels in the body?

Does Mela 5mg Tablet affect blood sugar levels?

Can Mela 5mg Tablet trigger gout?

Is Mela 5mg Tablet safe for people with kidney problems?

Can Mela 5mg Tablet cause dizziness or low blood pressure?

Does Mela 5mg Tablet affect calcium levels in the body?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

Related lab tests

Kidney Function Test

References

User feedback

What are you using Mela Tablet for?

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

Related/Popular tests