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Metolazone is used in fluid retention (edema), heart failure, increased blood pressure and kidney stone.

How it works

Metolazone lowers blood pressure and swelling by increasing the amount of urine, which removes extra water and certain electrolytes from the body.

Common side effects

Nausea, Nerve injury, Orthostatic hypotension (low blood pressure), Palpitations, Petechiae (red or purple spot caused by bleeding into the skin), Increased sensitivity to light, Abdominal bloating, Acute gouty attacks, Joint pain, Blood vessel inflammation, Blurred vision, Bone marrow failure, Chest discomfort, Chest pain, Chills, Constipation, Dehydration, Depression, Diarrhoea, Dizziness, Drowsiness, Gastrointestinal discomfort, Fainting, Fatigue, Bleeding gums, Headache, Inflammation of liver, Pancreatic inflammation, Increased glucose level in blood, Increased uric acid level in blood, Impotence, Increased blood urea nitrogen, Increased creatine level in blood, Increased glucose in urine, Insomnia, Jaundice, Loss of appetite, Muscle cramp, Rash, Restlessness, Tarry stools, Unpleasant breath odour, Vertigo, Vomiting, Weakness, Abnormal sensation in skin, Decreased potassium level in blood, Decreased white blood cell count


Expert advice

  • Do not take metolazone tablets, if you are allergic (hypersensitive) to sulfa drugs, thiazides, any other medications, metolazone or any of the other ingredients of metolazone tablet.
  • Do not take metolazone, if you are unable to urinate; if you have precoma or are in a coma caused by severe liver disease; if you have kidney or liver problem.
  • Avoid using metolazone, if you are pregnant or breastfeeding.
  • Consult your doctor, if you have or ever had diabetes, gout, low blood sodium or potassium levels, systemic lupus erythematosus.
  • Avoid prolonged exposure to sunlight.
  • Do not drive or operate machinery after taking metolazone.

Frequently asked questions


Q.Is metolazone potassium sparing diuretic/ loop diuretic/ beta blocker/ steroid/narcotic?
Metolazone belongs to the group of medicines called quinazoline and thiazide-like diuretic and it is not potassium sparing diuretic/ loop diuretic/ beta blocker/ steroid/narcotic

Q.Is metolazone discontinued?
No, metolazone is not discontinued

Q.Is metolazone stronger than Lasix?
Metolazone and furosemide (Lasix) belongs to same category of drugs (diuretics), but their effect may vary upon individual response

Q.Can you take metolazone with Lasix?
Metolazone and furosemide (Lasix) may sometimes be prescribed, but these combinations can lead to dehydration and electrolyte abnormalities. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required

Q.Does metolazone contain sulfa?
Yes, it contains sulfa. Chemically it is called as 7-chloro-2-methyl-4-oxo-3-o-tolyl-1, 2, 3, 4-tetrahydroquinazoline-6-sulfonamide

Q.Does metolazone get you high/ deplete potassium?
Metolazone causing the above side effects is uncommon or rare. However consult your doctor if you experience any of these side effects

Q.Does metolazone appear in breast milk?
Yes, metolazone gets excreted in breast milk. Patient should follow the advice of the doctor regarding its use

Q.How long does metolazone take to work?
It depends upon disease condition and lot of other factors. Patient should follow the advice of the doctor regarding its use.

Content on this page was last updated on 24 November, 2016, by Dr. Varun Gupta (MD Pharmacology)