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Macrozide 1500 Tablet

Written By Dr. Swati Mishra, BDS
Reviewed By Dr. Rajeev Sharma, MBA, MBBS
Last updated on 13 Mar 2026 | 01:39 PM (IST)
Macrozide 1500 Tablet is an antibiotic that belongs to a class of medicines known as anti tuberculosis drugs. It is used in the treatment of tuberculosis, an infectious disease that mainly affects the lungs and in some cases other parts of the body.
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General Information

Contains

Pyrazinamide (1500mg)

Marketer

Macleods Pharmaceuticals Pvt Ltd

Storage

Store below 25°C
The content is shown in English
Macrozide 1500 Tablet image
Macrozide 1500 Tablet image
Macrozide 1500 Tablet image
Macrozide 1500 Tablet image
Macrozide 1500 Tablet image
Macrozide 1500 Tablet image

Product introduction

Macrozide 1500 Tablet is given in combination with at least one other tuberculosis medicine. It acts by killing the causative bacteria. It should be used in the dose and duration as advised by your doctor. This medicine may be taken with or without food, preferably at a fixed time every day to avoid a missed dose. Do not skip any doses and finish the full course of treatment even if you feel better. Stopping it early can result in treatment failure and increase the side effects too. Please let your doctor know about any changes in your weight as the dose of this medicine depends on the overall body weight of a person. Any changes in weight might need dose modification.

If you miss a dose, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose, as it may increase the side effects.

Inform your doctor if you notice signs of jaundice i.e. yellowing of eyes or skin, dark urine, stomach pain or joint pain. You may also develop hepatitis (viral infection of the liver), increased liver enzymes and joint pain as side effects of this medicine. Please consult your doctor, as these side effects require medical attention and might need dose modification.

Your doctor may monitor your liver function while on treatment with this medicine. Avoid drinking alcohol as this may have additional adverse effects on the liver. Pregnant or breastfeeding women should consult their doctor before using this medicine.

Uses of Macrozide Tablet

Benefits of Macrozide Tablet

Tuberculosis (TB)
Macrozide 1500 Tablet is used to treat tuberculosis, an infectious disease that mainly affects the lungs but can affect other parts of the body as well. It stops the growth of infection causing bacteria and helps in treating the infection. Take it in the dose and duration advised by the doctor. Your symptoms may improve before the infection is completely cured. Do not stop taking it without consulting your doctor as doing so may cause the infection to return or worsen. Follow your doctor’s instructions carefully to get maximum benefit.

Side effects of Macrozide Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Macrozide
  • Jaundice
  • Hepatitis (viral infection of liver)
  • Increased liver enzymes
  • Joint pain

How to use Macrozide Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Macrozide 1500 Tablet may be taken with or without food.

How Macrozide Tablet works

Macrozide 1500 Tablet is an antitubercular medicine. In the body, it gets converted to pyrazinoic acid. This pyrazinoic acid inhibits fatty acid synthase I (bacterial enzyme), which is essential for bacterial growth. Thus, it works as a bacteriocidal to prohibit their growth and treats tuberculosis.

Quick tips

  • Macrozide 1500 Tablet along with other medications effectively treats tuberculosis.
  • Do not to forget a dose, as this increases the risk of the bacteria becoming resistant to the medicine, and also increases the risk of getting side effects.
  • Your doctor may check your liver function before starting treatment and regularly thereafter. Inform your doctor if you notice yellowing of eyes or skin, dark urine, or stomach pain.
  • Avoid drinking alcohol while taking Macrozide 1500 Tablet as this may increase the risk of side effects on the liver.
  • Use a reliable contraceptive method (such as condoms or a diaphragm) to prevent pregnancy while you are taking Macrozide 1500 Tablet as it may make hormonal contraceptives such as the pill less effective.

Safety advice

Alcohol

Alcohol

CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Macrozide 1500 Tablet. Please consult your doctor.
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
The safety of Macrozide 1500 Tablet during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.
Breast feeding

Breast feeding

CAUTION
Macrozide 1500 Tablet should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from the body.
Driving

Driving

CONSULT YOUR DOCTOR
It is not known whether Macrozide 1500 Tablet alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Please consult your doctor.
Kidney

Kidney

CAUTION
Macrozide 1500 Tablet should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.
Kidney function tests are advised before you start taking this medicine.
Liver

Liver

UNSAFE
Macrozide 1500 Tablet is unsafe to use in patients with liver disease and should be avoided.
Regular monitoring of liver function tests is advised before and after the start of the treatment.

Interaction with drugs

Taking Macrozide with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Moderate

Allopurinol (Oral Route)

If concurrent use is essential, your doctor may monitor your treatment and adjust the doses as per the observations. Allopurinol may reduce blood levels of Pyrazinamide.
Moderate

Bemiparin (Injection Route)

If concurrent use is essential, watch out for symptoms such as fatigue, nausea, loss of appetite, dark urine or jaundice and consult your doctor if you experience them. They may adjust the doses as per the observations.
Moderate

Certoparin (Injection Route)

If concurrent use is essential, watch out for symptoms such as fatigue, nausea, loss of appetite, dark urine or jaundice and consult your doctor if you experience them. They may adjust the doses as per the observations.
Moderate

Dalteparin (Injection Route)

If concurrent use is essential, watch out for symptoms such as fatigue, nausea, loss of appetite, dark urine or jaundice and consult your doctor if you experience them. They may adjust the doses as per the observations.
Moderate

Enoxaparin (Injection Route)

If concurrent use is essential, watch out for symptoms such as fatigue, nausea, loss of appetite, dark urine or jaundice and consult your doctor if you experience them. They may adjust the doses as per the observations.

Frequently asked questions

Macrozide 1500 Tablet is an antibiotic. It is used in combination with other antibiotics in the treatment of tuberculosis
Macrozide 1500 Tablet is both a bacteriostatic and a bactericidal antibiotic. It stops the growth of bacteria (bacteriostatic) in certain cases and kills (bactericidal) the tuberculosis causing bacteria in other cases
Macrozide 1500 Tablet kills or stops growth of bacteria that causes tuberculosis (Mycobacterium tuberculosis). The exact mechanism of action for Macrozide 1500 Tablet is not known
Following oral intake of Macrozide 1500 Tablet, it gets converted in the body to pyrazinoic acid (active chemical form of Macrozide 1500 Tablet). Pyrazinoic acid blocks the excretion of urates (salt form of uric acid) by the kidneys. This causes an increase in blood levels of uric acid (hyperuricemia). Excess uric acid accumulation between joints causes pain, swelling, redness and stiffness in joints (gout).

Fact Box

Chemical Class

Pyrazines

Habit Forming

No

Therapeutic Class

ANTI INFECTIVES

Action Class

Mycobacterial fatty acid synthase

Related lab tests

Complete Blood Count

Erythrocyte Sedimentation Rate

Mycobacterium Tuberculosis DNA PCR - Qualitative

Peripheral Smear Examination

References

  1. Gumbo T. Chemotherapy of Tuberculosis, Mycobacterium Avium Complex Disease, and Leprosy. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1554-555.
  2. Chambers HF, Deck DH. Antimycobacterial Drugs. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 827.
  3. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1171-72.
  4. Chaves RG, Lamounier JA. Breastfeeding and maternal medications. J Pediatr (Rio J). 2004;80(5 Suppl):S189-S198 [Accessed 29 Mar. 2019] (online) Available from:
  5. Central Drugs Standard Control Organisation (CDSCO). [Accessed 31 Mar. 2019] (online) Available from:
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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Macleods Pharmaceuticals Pvt Ltd
Address: Atlanta Arcade, Marol Church Road, Andheri (East), Mumbai - 400059, INDIA.

Vendor Details

Country of origin: India

Lab tests offered by us

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