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Allopurinol is used in the treatment of gout
It is a long-term treatment to lower blood uric acid levels and to prevent gout attacks. It also prevents and treats calcium kidney stones.

How it works

Allopurinol blocks the enzyme xanthine oxidase involved in the synthesis of uric acid and hence lowers the blood uric acid levels.

Common side effects

Skin rash

Available Medicine

  • ₹18 to ₹73
    Glaxo SmithKline Pharmaceuticals Ltd
    2 variant(s)
  • ₹18 to ₹58
    Cipla Ltd
    2 variant(s)
  • ₹18 to ₹69
    Cipla Ltd
    2 variant(s)
  • ₹23 to ₹65
    Inga Laboratories Pvt Ltd
    2 variant(s)
  • ₹26 to ₹38
    Kivi Labs Ltd
    2 variant(s)
  • ₹71
    Novartis India Ltd
    1 variant(s)
  • ₹62
    M. Frank Pharmaceuticals
    1 variant(s)
  • ₹7 to ₹152
    Psychotropics India Ltd
    2 variant(s)
  • ₹27 to ₹77
    Organic Laboratories
    2 variant(s)
  • ₹17
    Intas Pharmaceuticals Ltd
    1 variant(s)

Expert advice

  • Allopurinol is not a painkiller and it may take a few days to weeks before it starts working. You would need to take additional medicines to relieve your pain and inflammation during this time.
  • You may experience an increase in gouty attacks for first few weeks or months of taking Allopurinol. However, you must continue to take your medicine during these attacks.
  • Do not stop taking Allopurinol at once or without talking to your doctor as this may make gout worse.
  • Drink lots of water or fluids while taking Allopurinol to decrease the risk of kidney stone formation.
  • Get blood uric acid levels checked at regular intervals.
  • Get your liver function tests done before you start taking this medicine and whenever asked by your doctor as Allopurinol can affect your liver.
  • Allopurinol can make you feel drowsy. Avoid driving, use of machinery, or any activity that requires you to be alert.

Frequently asked questions


Q. Is allopurinol/Zyloric safe?
Allopurinol/Zyloric is safe if used at prescribed doses for the prescribed duration as advised by your doctor
Q. Is allopurinol a narcotic or an antibiotic or nephrotoxic or NSAID or steroid or diuretic?
No, allopurinol belongs to a group of medicines called enzyme inhibitors. It reduces the amount of uric acid in the body by blocking one of the processes that makes it. It is used to treat gout (pain and swelling of the small joints due to elevated levels of uric acid in the blood and subsequent deposition in the joints, kidney stones, in some types of Cancer due to increase in the amount of uric acid in the body and enzyme disorders due to increase in the amount of uric acid in the body
Q. Is allopurinol generic?
Yes, allopurinol is a generic name. However, it is available in the market with different brand names
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Q. Can I take allopurinol with indomethacin or naproxen or prednisone or ibuprofen or diclofenac or metformin or flucloxacillin?
No results found for any interaction of allopurinol with all these drugs,, but always consult with your doctor before taking this medication
Q. Can I take allopurinol with colchicine (Colcrys)?
No. Colchicine interacts with allopurinol. Do not take colchicine with allopurinol
Q. Does allopurinol affect the liver?
Yes, allopurinol alters the liver enzyme and in rare cases it may cause jaundice (yellowish of skin and eye)
Q. Does allopurinol affect blood pressure?
Yes, allopurinol has shown low but significant effect in reducing the blood pressure
Q. Does allopurinol affect kidneys?
Allopurinol decreases C-reactive protein and slows the progression of renal disease in patients with chronic kidney disease
Q. Does allopurinol affect blood sugar?
There is no conclusive proof that it affects blood sugar
Q. Does allopurinol affect male fertility?
Yes, it may cause infertility in male
Q. Does allopurinol cause weight gain?
It may cause rapid weight gain.

Content on this page was last updated on 09 May, 2017, by Dr. Varun Gupta (MD Pharmacology)