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    Allopurinol

    Information about Allopurinol

    Allopurinol uses

    Allopurinol is used in the treatment of gout
    It is a long-term treatment to lower blood uric acid levels and to prevent gout attacks. It also prevents and treats calcium kidney stones.

    How allopurinol works

    Allopurinol blocks the enzyme xanthine oxidase involved in the synthesis of uric acid and hence lowers the blood uric acid levels.

    Common side effects of allopurinol

    Skin rash

    Available Medicine for Allopurinol

    • ₹18 to ₹75
      Glaxo SmithKline Pharmaceuticals Ltd
      2 variant(s)
    • ₹24 to ₹58
      Cipla Ltd
      2 variant(s)
    • ₹18 to ₹69
      Cipla Ltd
      2 variant(s)
    • ₹23 to ₹65
      Inga Laboratories Pvt Ltd
      2 variant(s)
    • ₹26 to ₹38
      Kivi Labs Ltd
      2 variant(s)
    • ₹71
      Novartis India Ltd
      1 variant(s)
    • ₹62
      M. Frank Pharmaceuticals
      1 variant(s)
    • ₹7 to ₹152
      Psychotropics India Ltd
      2 variant(s)
    • ₹27 to ₹77
      Organic Laboratories
      2 variant(s)
    • ₹22 to ₹57
      Cipla Ltd
      2 variant(s)

    Expert advice for Allopurinol

    • Allopurinol is not a painkiller and it may take a few days to weeks before it starts working. You would need to take additional medicines to relieve your pain and inflammation during this time.
    • You may experience an increase in gouty attacks for first few weeks or months of taking Allopurinol. However, you must continue to take your medicine during these attacks.
    • Do not stop taking Allopurinol at once or without talking to your doctor as this may make gout worse.
    • Drink lots of water or fluids while taking Allopurinol to decrease the risk of kidney stone formation.
    • Get blood uric acid levels checked at regular intervals.
    • Get your liver function tests done before you start taking this medicine and whenever asked by your doctor as Allopurinol can affect your liver.
    • Allopurinol can make you feel drowsy. Avoid driving, use of machinery, or any activity that requires you to be alert.

    Frequently asked questions for Allopurinol

    Allopurinol

    Q. Is allopurinol/Zyloric safe?
    Allopurinol/Zyloric is safe if used at prescribed doses for the prescribed duration as advised by your doctor
    Q. Is allopurinol a narcotic or an antibiotic or nephrotoxic or NSAID or steroid or diuretic?
    No, allopurinol belongs to a group of medicines called enzyme inhibitors. It reduces the amount of uric acid in the body by blocking one of the processes that makes it. It is used to treat gout (pain and swelling of the small joints due to elevated levels of uric acid in the blood and subsequent deposition in the joints, kidney stones, in some types of Cancer due to increase in the amount of uric acid in the body and enzyme disorders due to increase in the amount of uric acid in the body
    Q. Is allopurinol generic?
    Yes, allopurinol is a generic name. However, it is available in the market with different brand names
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    Q. Can I take allopurinol with indomethacin or naproxen or prednisone or ibuprofen or diclofenac or metformin or flucloxacillin?
    No results found for any interaction of allopurinol with all these drugs,, but always consult with your doctor before taking this medication
    Q. Can I take allopurinol with colchicine (Colcrys)?
    No. Colchicine interacts with allopurinol. Do not take colchicine with allopurinol
    Q. Does allopurinol affect the liver?
    Yes, allopurinol alters the liver enzyme and in rare cases it may cause jaundice (yellowish of skin and eye)
    Q. Does allopurinol affect blood pressure?
    Yes, allopurinol has shown low but significant effect in reducing the blood pressure
    Q. Does allopurinol affect kidneys?
    Allopurinol decreases C-reactive protein and slows the progression of renal disease in patients with chronic kidney disease
    Q. Does allopurinol affect blood sugar?
    There is no conclusive proof that it affects blood sugar
    Q. Does allopurinol affect male fertility?
    Yes, it may cause infertility in male
    Q. Does allopurinol cause weight gain?
    It may cause rapid weight gain.
    Q. Can I take Allopurinol with Torasemide?
    Allopurinol can be taken with Torasemide. Torasemide can cause increased uric acid levels and Allopurinol lowers uric acid levels. So, Allopurinol is given to decrease the hyperuricemic effects of Torasemide. However, Allopurinol is not safe in patients with renal failure, so may need to be replaced with another similar medicine like febuxostat.
    Q. How is Allopurinol different from febuxostat?
    Both Allopurinol and febuxostat work in a similar way by lowering uric acid levels. However, as compared to Allopurinol, febuxostat is seen to be more effective and faster in its action. Also, in patients taking Allopurinol, a dose adjustment is needed if the patient has mild, moderate or severe renal failure while in the case of febuxostat a dose adjustment may be needed only in patients with severe renal failure.
    Q. Can I take Allopurinol with febuxostat?
    Both Allopurinol and febuxostat are uric acid lowering agents and work in a similar way. So, using both the two medicines together may not be very beneficial and can increase the risk of side effects. However, there have been studies where febuxostat when used with Allopurinol in patients with refractory gout, was quite effective in providing relief. So, a combined use would be best decided by your treating doctor depending on your condition.

    Content on this page was last updated on 03 July, 2017, by Dr. Varun Gupta (MD Pharmacology)