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    Pyrazinamide

    Information about Pyrazinamide

    Pyrazinamide uses

    Pyrazinamide is used in the treatment of tuberculosis.

    How pyrazinamide works

    Pyrazinamide is an antibiotic. It works by slowing the growth of bacteria that causes tuberculosis.

    Common side effects of pyrazinamide

    Jaundice, Hepatitis (viral infection of liver), Increased liver enzymes, Joint pain
    Content Details
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    Written By
    Dr. Sakshi Sharma
    BDS
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    Reviewed By
    Dr. Ashish Ranjan
    MD (Pharmacology), MBBS
    Last updated on:
    16 Oct 2019 | 01:31 PM (IST)
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    Available Medicine for Pyrazinamide

    • ₹43 to ₹97
      Lupin Ltd
      4 variant(s)
    • ₹43 to ₹97
      Cadila Pharmaceuticals Ltd
      3 variant(s)
    • ₹26 to ₹84
      Macleods Pharmaceuticals Pvt Ltd
      5 variant(s)
    • ₹6 to ₹63
      Novartis India Ltd
      3 variant(s)
    • ₹49 to ₹81
      Marc Laboratories Pvt Ltd
      3 variant(s)
    • ₹17 to ₹112
      Kopran Ltd
      3 variant(s)
    • ₹40 to ₹65
      Themis Medicare Ltd
      2 variant(s)
    • ₹39 to ₹62
      Sunij Pharma Pvt Ltd
      2 variant(s)
    • ₹76
      Concept Pharmaceuticals Ltd
      1 variant(s)
    • ₹54 to ₹58
      Que Pharma Pvt Ltd
      2 variant(s)

    Expert advice for Pyrazinamide

    • Pyrazinamide along with other medications effectively treats tuberculosis.
    • Do not to forget a dose, as this increases the risk of the bacteria becoming resistant to the medicine, and also increases the risk of getting side effects.
    • Your doctor may check your liver function before starting treatment and regularly thereafter. Inform your doctor if you notice yellowing of eyes or skin, dark urine, or stomach pain.
    • Avoid drinking alcohol while taking Pyrazinamide as this may increase the risk of side effects on the liver.
    • Use a reliable contraceptive method (such as condoms or a diaphragm) to prevent pregnancy while you are taking Pyrazinamide as it may make hormonal contraceptives such as the pill less effective.

    Frequently asked questions for Pyrazinamide

    Pyrazinamide

    Q. What is Pyrazinamide and what is it used for?

    Pyrazinamide is an antibiotic. It is used in combination with other antibiotics in the treatment of tuberculosis

    Q. Is Pyrazinamide bactericidal?

    Pyrazinamide is both a bacteriostatic and a bactericidal antibiotic. It stops the growth of bacteria (bacteriostatic) in certain cases and kills (bactericidal) the tuberculosis causing bacteria in other cases

    Q. How does Pyrazinamide work/treat tuberculosis?

    Pyrazinamide kills or stops growth of bacteria that causes tuberculosis (Mycobacterium tuberculosis). The exact mechanism of action for Pyrazinamide is not known

    Q. How does Pyrazinamide cause hyperuricemia and gout?

    Following oral intake of Pyrazinamide, it gets converted in the body to pyrazinoic acid (active chemical form of Pyrazinamide). Pyrazinoic acid blocks the excretion of urates (salt form of uric acid) by the kidneys. This causes an increase in blood levels of uric acid (hyperuricemia). Excess uric acid accumulation between joints causes pain, swelling, redness and stiffness in joints (gout).

    Content on this page was last updated on 16 October, 2019, by Dr. Varun Gupta (MD Pharmacology)