DISTamine 250mg Capsule

Penicillamine (250mg)

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DISTamine 250mg Capsule is used in the treatment of rheumatoid arthritis, Wilson's disease, and cystinuria. It slows the progression of rheumatoid arthritis and provides relief from pain and swelling in the joints. In the treatment of Wilson's disease, it helps to remove the excess copper from the body.

Written By Dr. Subita Alagh, BDS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 20 Apr 2026 | 12:22 PM (IST)

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DISTamine 250mg Capsule

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Penicillamine (250mg)

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General Information

Contains

Penicillamine (250mg)

Marketer

Neon Laboratories Ltd

Storage

Store below 30°C

The content is shown in English

Product introduction

DISTamine 250mg Capsule is to be taken on an empty stomach. You should take it regularly and at the same time each day to get maximum benefit from it. Keep taking it as recommended by your doctor and complete the dose even if you feel better.

Using this medicine may cause some common side effects such as rashes, nausea, vomiting, and diarrhea. Your doctor may recommend regular blood tests to check and make sure the medicine is not harming your liver or affecting your blood counts. You should consult with your doctor if any of these side effects do not resolve with time or get worse. Your doctor may help with ways to reduce or prevent these symptoms.

To make sure the medicine is safe for you, before taking this medicine, let your doctor know if you have any problems with your kidneys. Also, tell your doctor about all the other medicines you are taking. Pregnant and breastfeeding mothers should consult with their doctors before taking the medicine.

Uses of DISTamine Capsule

Treatment of Rheumatoid arthritis
Treatment of Wilson's disease

Benefits of DISTamine Capsule

Treatment of Rheumatoid arthritis
Rheumatoid arthritis is an autoimmune condition where the immune system attacks the joints, causing pain, swelling, and stiffness. DISTamine 250mg Capsule is used to manage symptoms in patients who haven't responded well to other treatments. It can slow joint damage and improve mobility over time.

Treatment of Wilson's disease
Wilson's disease is a rare genetic disorder where excess copper builds up in the body, damaging organs like the liver and brain. DISTamine 250mg Capsule helps by binding to the excess copper, allowing it to be safely removed from the body, which helps prevent organ damage and supports long-term health.

Side effects of DISTamine Capsule

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of DISTamine

Vomiting
Nausea
Hypoglycemia (low blood glucose level)
Diarrhea
Rash

How to use DISTamine Capsule

Take this medicine in the dose and duration as advised by your doctor. DISTamine 250mg Capsule is to be taken on an empty stomach.

How DISTamine Capsule works

DISTamine 250mg Capsule works by blocking the action of certain chemical messengers that are responsible for inflammation and slows the progress of the condition with certain joint diseases. It works in Wilson's disease by helping the body to remove excess copper, and in cystinuria by preventing cystine stone formation through increased solubility.

All substitutes for DISTamine 250mg Capsule

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

Take DISTamine 250mg Capsule on an empty stomach, at least 1 hour before or 2 hours after meals, for better absorption.
Avoid taking it with iron, antacids, or zinc supplements within 2 hours, as they may reduce its effectiveness.
Inform your doctor if you notice any signs of infection, bruising, or fatigue, as regular blood monitoring is essential.
Use effective contraception if you're of childbearing age, as DISTamine 250mg Capsule may harm an unborn baby.
Stay hydrated and follow any dietary restrictions advised by your doctor to reduce the risk of side effects.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with DISTamine 250mg Capsule. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

DISTamine 250mg Capsule is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.

Breast feeding

CONSULT YOUR DOCTOR

DISTamine 250mg Capsule may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.
Taking DISTamine 250mg Capsule right after nursing and waiting for 4 to 6 hours before nursing again will minimize the harmful effects to the baby.

Driving

UNSAFE

DISTamine 250mg Capsule may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Kidney

CAUTION

DISTamine 250mg Capsule should be used with caution in patients with kidney disease. Dose adjustment may be needed.
Use of DISTamine 250mg Capsule is not recommended in patients with severe kidney disease.

Liver

SAFE IF PRESCRIBED

DISTamine 250mg Capsule is safe to use in patients with liver disease. No dose adjustment is recommended.

Interaction with drugs

Taking DISTamine with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Severe

Leflunomide (Oral Route)

If concurrent use is essential, your doctor may monitor your treatment and adjust the doses as per the observations.

Severe

Teriflunomide (Oral Route)

If concurrent use is essential, your doctor may monitor your treatment and adjust the doses as per the observations.

Moderate

Clozapine (Oral Route)

Do not consume Clozapine with Penicillamine. If concurrent use is essential, your doctor may monitor your blood cell count frequently.

Moderate

Digoxin (Oral Route)

If concurrent use is essential, ensure a gap of at least 2 hours between taking Digoxin and Penicillamine. Your doctor may monitor your treatment and adjust the doses as per the observations. Penicillamine may reduce blood levels of active form of Digoxin.

Moderate

Aceclofenac (Oral Route)

Do not consume Penicillamine with Aceclofenac. If concurrent use is essential, please consult your doctor.

Frequently asked questions

What is DISTamine 250mg Capsule used for?

DISTamine 250mg Capsule is prescribed for several conditions, such as in Wilson's disease (excess copper in the body), severe rheumatoid arthritis, and certain types of kidney stones (cystinuria). Your doctor may also prescribe DISTamine 250mg Capsule in case of heavy metal (lead) poisoning. Your doctor will determine if it is right for your specific condition.

What foods and supplements should I avoid?

You should avoid taking milk, antacids, zinc, or iron-containing supplements within 2 hours of taking DISTamine 250mg Capsule. Additionally, avoid copper-rich foods if you have Wilson’s disease and other mineral supplements unless approved by your doctor.

What serious side effects should I watch for?

You should seek immediate medical attention during DISTamine 250mg Capsule treatment if you experience serious side effects such as unusual bleeding or bruising, fever or sore throat, unusual tiredness, blood in urine, joint pain, swelling, severe breathing difficulty, rash, etc. These could indicate serious complications requiring prompt attention.

How long does it take to see results?

The exact time DISTamine 250mg Capsule takes to show results is not known. The timeline for noticeable improvement varies by individual, condition, and its severity. The initial improvement in symptoms may take a few months. You should continue taking DISTamine 250mg Capsule even if you feel better and follow your doctor’s instructions and restrictions.

Are there special precautions for pregnancy?

You should inform your doctor if pregnant or planning pregnancy, as this may require adjusting or changing treatment and regular monitoring during pregnancy. DISTamine 250mg Capsule may be contraindicated in some cases. Discuss risks and benefits with your doctor.

Fact Box

Chemical Class

Valine derivative

Habit Forming

Therapeutic Class

BLOOD RELATED

Action Class

Non-Biologic DMARDs (Disease Modifying Anti-Rheumatoid Drugs)

Related lab tests

Rheumatoid Factor - Agglutination

Rheumatoid Factor - Turbidometry

Rheumatoid Factor IgG Antibody

References

Aminoff MJ. Pharmacologic Management of Parkinsonism & Other Movement Disorders. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 482.
Byrns MC, Penning TM. Environmental Toxicology: Carcinogens and Heavy Metals. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 1875.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1079-80.
Penicillamine.Hunt Valley, USA: Pharmaceutics International, Inc.; 2018. [Accessed 02 Apr. 2019] (online) Available from:
Penicillamine [Package Insert]. Princeton, NJ: Dr. Reddy’s Laboratories Inc.; 2018. [Accessed 03 Aug. 2023] (online) Available from:

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Neon Laboratories Ltd
Address: 140, Damji Samji Industrial Complex, Mahakali Caves Rd., Andheri(East), Mumbai-93.

Vendor Details

Country of origin: India

Lab tests offered by us

Why we need a prescription?

DISTamine 250mg Capsule

Save more with additional offers

General Information

Contains

Marketer

Storage

Product introduction

Uses of DISTamine Capsule

Benefits of DISTamine Capsule

Side effects of DISTamine Capsule

How to use DISTamine Capsule

How DISTamine Capsule works

All substitutes for DISTamine 250mg Capsule

Cilamin 250 Capsule

Penicitin 250mg Capsule

Jollimine Capsule

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Leflunomide (Oral Route)

Teriflunomide (Oral Route)

Clozapine (Oral Route)

Digoxin (Oral Route)

Aceclofenac (Oral Route)

Frequently asked questions

What is DISTamine 250mg Capsule used for?

What foods and supplements should I avoid?

What serious side effects should I watch for?

How long does it take to see results?

Are there special precautions for pregnancy?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

Related lab tests

Rheumatoid Factor - Agglutination

Rheumatoid Factor - Turbidometry

Rheumatoid Factor IgG Antibody

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

Related/Popular tests