Information about Leflunomide

Leflunomide uses

Leflunomide is used in the treatment of rheumatoid arthritis and psoriatic arthritis.

How leflunomide works

Leflunomide blocks the action of certain chemical messengers that are responsible for inflammation, swelling and redness associated with certain autoimmune diseases. It suppresses the underlying disease process, rather than simply treating the disease.

Common side effects of leflunomide

Nausea, Headache, Dyspepsia, Rash, Diarrhoea, Increased liver enzymes, Respiratory tract infection.

Available Medicine for Leflunomide

  • ₹97 to ₹191
    Torrent Pharmaceuticals Ltd
    2 variant(s)
  • ₹98 to ₹196
    Ipca Laboratories Ltd
    3 variant(s)
  • ₹177 to ₹425
    Zydus Cadila
    3 variant(s)
  • ₹292 to ₹572
    Sanofi India Ltd
    2 variant(s)
  • ₹97 to ₹191
    Cipla Ltd
    2 variant(s)
  • ₹97 to ₹191
    Sun Pharmaceutical Industries Ltd
    2 variant(s)
  • ₹96
    Wallace Pharmaceuticals Pvt Ltd
    1 variant(s)
  • ₹98 to ₹182
    Overseas Healthcare Pvt Ltd
    2 variant(s)
  • ₹89 to ₹170
    Ronyd Healthcare Pvt Ltd
    2 variant(s)
  • ₹240
    Rhumasafe Pharmaceutical
    1 variant(s)

Expert advice for Leflunomide

  • Do not drive or operate machinery because you may feel sleepy or dizzy while being treated with leflunomide.
  • Do not start leflunomide, if you have a kidney, liver, blood or lung problem; have low level of proteins in blood (hypoproteinemia), low level of any blood cells, or suffering from any disease with lowered immunity like tuberculosis or AIDS.
  • Do not start leflunomide, if you have intolerance to some sugars because this medicine contains lactose (a type of sugar).
  • Do not take leflunomide, if you are going to receive any live vaccine; or if you experience a widespread rash with blisters and peeling skin (Stevens-Johnson syndrome), widespread peeling of the superficial layers of the skin (toxic epidermal necrolysis),or drug reaction with eosinophilia and systematic symptoms (DRESS).
  • Avoid using leflunomide, if you are pregnant or planning to become pregnant, breastfeeding.

Frequently asked questions for Leflunomide


Q. Is leflunomide an NSAID, immunosuppressant, blood thinner, chemotherapeutic agent?
No, leflunomide is not an NSAID, blood thinner or chemotherapeutic agent. It is an immunosuppressant anti-rheumatic drug
Q. Can I take Tylenol (acetaminophen), or ibuprofen with leflunomide, or Arava?
You can take Tylenol or ibuprofen with leflunomide or Arava which is brand name of leflunomide
Q. Does leflunomide cause weight or hair loss, bruising, high blood pressure, nausea, cancer, fatigue, or weight gain?
Leflunomide may cause weight or hair loss, bruising, high blood pressure, and nausea (urge to vomit), but it is not known to cause weight gain, fatigue or cancer
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Q. Does leflunomide help psoriasis?
Yes, leflunomide is used in the treatment of psoriasis.

Content on this page was last updated on 25 May, 2017, by Dr. Varun Gupta (MD Pharmacology)