Diagraf 500mg Tablet

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GRAF Laboratories Pvt Ltd

Composition for Diagraf 500mg Tablet

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Primarily used for

Potentiallyunsafewith
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Alcohol
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Liver
20.95
₹2.09/Tablet
10 tablets in 1 strip
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Medicine Overview of Diagraf Tablet

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Uses of Diagraf Tablet

Diagraf 500mg Tablet is used in the treatment of type 2 diabetes.
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Side effects of Diagraf Tablet

Common

Nausea, Vomiting, Altered taste, Diarrhoea, Abdominal pain, Loss of appetite.

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How to use Diagraf Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. It is better to take Diagraf 500mg Tablet with food.

How Diagraf Tablet works

Diagraf 500mg tablet is an anti-diabetic medicine. It restores the body's ability to use insulin, lowering the blood sugar levels. It also decreases the amount of glucose absorbed from food in the intestine and decreases glucose production in the liver.

In Depth Information on Diagraf Tablet

Expert advice for Diagraf Tablet

  • Well tolerated antidiabetic medicine with a low risk of weight gain and hypoglycemia.
  • Can cause hypoglycemia (low blood sugar level) when used with other antidiabetic medicines, alcohol or if you delay or miss a meal. Get blood sugar levels checked at regular intervals and always keep a source of sugar with you for quick relief.
  • Inform your doctor if you have a kidney disease. Your dose may need to be adjusted.
  • Take it with food to avoid stomach upset like nausea, gas, stomach pain and diarrhea. However, this usually gets relieved on its own. Contact your doctor if it persists for a long time.
  • Can cause Vitamin B12 deficiency and symptoms of anemia like tiredness, pale skin, shortness of breath or headache. Inform your doctor as you may need supplements.
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Warnings
Special precautions for Diagraf 500mg Tablet
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Alcohol
CAUTION
Taking metformin with alcohol can cause lactic acidosis and
you may experience malaise, respiratory distress, slow or irregular heartbeat, sleepiness, stomach upset, or other unusual symptoms.
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Pregnancy
PROBABLY SAFE
Diagraf 500mg Tablet is probably safe to use during pregnancy.

Animal studies have shown low or no adverse effect on the foetus, however, there are limited human studies. Please consult your doctor.
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Lactation
Diagraf 500mg Tablet is probably safe to use during lactatio
n. Limited human data suggests that the drug does not represent a significant risk to the baby.
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Driving
Your ability to drive may be affected if your blood sugar is
low or high. If this happens, do not drive.
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Kidney
CAUTION
Diagraf 500mg Tablet should be used with caution in patients with kidney disease. Dose adjustment of Diagraf 500mg Tablet may be needed. Please consult your doctor.

Use of Diagraf 500mg Tablet should be avoided if you have serious kidney disease. A regular monitoring of kidney function test may be advised while you are taking this medicine
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Liver
UNSAFE
Diagraf 500mg Tablet is probably unsafe to use in patients with liver disease and should be avoided. Please consult your doctor.

Should be used cautiously in patients with an underlying liver disease. Please consult your doctor.
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Severely interacts with other drugs like
Decmax 4mg Tablet, Rantac 50mg/2ml Injection, Peptiran 75mg/5ml Syrup, Decamycin 4mg Injection

Missed Dosageuses

If you miss a dose of Metformin, skip it and continue with your normal schedule. Do not double the dose.

Patient Concerns

Frequently asked questions for Diagraf 500mg Tablet

Frequently asked questions for Metformin

Diagraf is commonly used off-label for the treatment of polycystic ovary syndrome (PCOS). It regulates ovulation and androgen levels in the body which improves menstrual cycles and pregnancy rates and outcomes in these patients. It also improves the insulin sensitivity and prevents the development of gestational diabetes and type 2 diabetes mellitus commonly seen in these patients.
Diagraf helps in weight loss by decreasing hunger (appetite) and hence food intake. It makes the insulin already available in your body to work more effectively. This leads to decrease glucose production, increase glucose use and decreased fat deposits which further helps to lower body weight. However, it is not yet approved for weight loss, this is an off-label use.
Diagraf is commonly used off-label for the treatment of infertility associated with polycystic ovary syndrome (PCOS). It regulates ovulation and androgen levels in the body and improves menstrual regularity and pregnancy rates and outcomes. This beneficial effect is thought to be due to improvement in insulin resistance by Diagraf.
Diagraf can lower blood sugar level (hypoglycemia). It happens more often if you delay or miss your food, do more than your routine exercise, drink alcohol or take other antidiabetic medicine along with. So, regular monitoring of blood sugar level is important and be cautious of symptoms of hypoglycemia and always keep glucose tablets, honey or fruit juice with you.
Diagraf is generally a safe and well-tolerated drug even on long-term use. However, its long-term use can cause vitamin B12 deficiency leading to anemia and peripheral neuropathy (nerve damage). so, it should be taken only at prescribed doses for the duration as advised by the doctor.
No, Diagraf is not a sulfonylurea. It is an antidiabetic drug used to control high blood sugar levels in newly-diagnosed type 2 diabetes patients, along with modification in diet and exercise.
No, Diagraf is not a steroid. It is an antidiabetic drug used to control high blood sugar levels in newly-diagnosed type 2 diabetes patients, along with modifications in diet and exercise.
Diagraf commonly causes stomach upset like bloating (heavy and uncomfortable feeling in the stomach), nausea, vomiting, and diarrhea. To avoid these side effects, it is advised to be taken after meals, preferably started at a low dose and then increased slowly over weeks, or by using slow-release tablets.
Diagraf is seen to be beneficial in the treatment of non-alcoholic fatty liver disease (NAFLD). One of the underlying cause of NAFLD is insulin resistance. Diagraf improves insulin resistance and liver enzymes in these patients. It is not seen to benefit patients of alcoholic fatty liver disease and is usually avoided in patients with liver cirrhosis as they are at an increased risk of lactic acidosis.
Q. What is the benefit of combining Diagraf with coenzyme q10?
Coenzyme Q10 is an antioxidant that helps in energy production and is found in heart, liver, kidney, and pancreas (which produces insulin). It can repair the damage caused to these organs by free radicals. Low levels of CoQ10 are seen in patients with diabetes. So, some researchers suggest it be given from outside. It can be taken with Diagraf as no drug-drug interactions or harmful effects have been seen between the two.
Yes, Diagraf does improve menstrual cycle (periods) regularity in women with polycystic ovarian syndrome (PCOS). It is associated with insulin resistance, decreased ovulation, and high androgen levels which cause menstrual irregularities like delayed periods and scanty bleeding. Diagraf helps in regularizing menstrual cycles by improving insulin sensitivity, ovulation rate, and decreasing androgen levels.
Q. Can I take Diagraf with atorvastatin?
Yes, Diagraf can be taken with atorvastatin. There are no reported harmful effects when they are used together. Rather some studies suggest beneficial effects in diabetics as they may prevent a very high increase in blood glucose after food, decrease some inflammation markers and protect the patients from liver injury.
Q. Can I take Diagraf with phentermine?
Diagraf can be taken with phentermine. These are sometimes given together in obese patients who are also diabetic and are taking Diagraf along with exercise and diet modification. Phentermine decreases food intake by its action in the brain. However, phentermine can decrease the effect of Diagraf leading to very high blood glucose levels. So, a dose adjustment of Diagraf may be needed.
Q. Can I take Diagraf with levothyroxine?
Diagraf can be taken with levothyroxine but the dose of Diagraf may need to be adjusted. Levothyroxine can decrease the effect of Diagraf leading to very high blood glucose levels. These are used together in patients with coexisting thyroid disease and diabetes mellitus or polycystic ovarian syndrome (PCOS).
Q. Can I take Diagraf with prednisolone?
Diagraf can be taken with prednisolone but the dose of Diagraf may need to be adjusted. Prednisolone can decrease the effect of Diagraf leading to very high blood glucose levels. Continuous use of steroids like prednisolone can also cause diabetes known as glucocorticoid-induced diabetes and use of Diagraf is recommended in these patients.
Q. Can I take Diagraf with metoprolol?
Diagraf can be taken with metoprolol. There are no reported drug interactions or harmful effects in humans when they are used together. However, some animal studies suggest that metoprolol can decrease the blood levels of Diagraf and on long-term use can increase lactic acid and uric acid levels.
Diagraf is not indicated for clearing acne due to just any condition. It only helps in clearing acne in women with polycystic ovarian syndrome (PCOS) along with other problems like facial hair, abdominal obesity, and irregular menstruation.
No, hair loss has not been reported with Diagraf. It only helps in clearing facial hair (hirsutism) in women with polycystic ovarian syndrome (PCOS) along with other problems like acne, abdominal obesity, and irregular menstruation.
No, weight gain has not been reported with Diagraf. Rather it helps in decreasing weight especially abdominal fat patients of type 2 diabetes mellitus and in women with polycystic ovarian syndrome (PCOS) along with other problems like facial hair, acne, and irregular menstruation.
Diagraf is not known to cause constipation. Some common side effects associated with the use of Diagraf includes nausea, vomiting, abdominal pain, altered taste, diarrhea, and loss of appetite.
Diagraf is a safe and well-tolerated drug even on long-term use when taken strictly as advised by the doctor. However, there are some very common side effects like nausea, vomiting, abdominal pain, altered taste, diarrhea, and loss of appetite you may experience even at therapeutic doses.
Diagraf is not known to increase blood pressure. Some common side effects associated with the use of Diagraf includes nausea, vomiting, abdominal pain, altered taste, diarrhea, and loss of appetite.
No, Diagraf is not an insulin. Diagraf is an oral drug used in type 2 diabetes mellitus and lowers blood glucose levels by decreasing its production and increasing absorption and making the already available insulin in your body to work better. Insulin is a normally produced hormone in the body, used in the injectable form in the treatment of both type 1 and 2 diabetes mellitus and it works by absorbing and storing glucose from the blood.
No, Diagraf is not a banned drug. It is a prescription medicine and is available when prescribed by registered medical practitioner.
No, Diagraf is not a birth control pill. It is an antidiabetic drug used to control high blood sugar levels in newly-diagnosed type 2 diabetes patients, along with modification in diet and exercise.
No, Diagraf is not a statin. It is an antidiabetic drug used to control high blood sugar levels in newly-diagnosed type 2 diabetes patients, along with modification in diet and exercise.
Q. Can I take Diagraf with saxagliptin?
Both Diagraf and saxagliptin are anti diabetic drugs and can be used together. Their fixed dose combinations are also available and commonly advised once Diagraf is unable to control blood sugar levels even after giving the maximum tolerated dose. As they work by different mechanisms, they help in better control of blood sugar levels compared to either drug taken alone.
Diagraf is not known to cause blurred vision. Change in vision in a patient with diabetes could be due to multiple reasons. It could be a temporary problem either due to high blood sugar levels which cause your lens inside your eye to swell and change your vision. If the blurred vision continues for a long time, consult a doctor.
Lactic acidosis is a rare, but serious complication associated with the use of Diagraf. Patient has high blood lactic acid levels and may present with tiredness, weakness, stomach pain, loose stools, severe muscle pain, muscle cramps and difficulty in breathing. It is especially seen in old age patients, those with kidney, liver or heart disease, or who take large amounts of alcohol. If you have these symptoms, stop taking Diagraf and consult your doctor.
Diagraf is not known to cause any liver pain or damage. Rather, it is seen to be useful in patients with non-alcoholic fatty liver disease (NAFLD) and chronic hepatitis C. However, it is usually avoided in patients with liver cirrhosis as they are at an increased risk of lactic acidosis which is a serious complication associated with the use of Diagraf.
No, Diagraf does not elevate the mood or make you feel high. It is an antidiabetic drug used to control high blood sugar levels in newly-diagnosed type 2 diabetes patients, along with modification in diet and exercise. Rare side effects of Diagraf include anxiety and depression.
Usually, Diagraf is not associated with back pain. However, it can be a presentation of stomach upset, a common side effect caused by Diagraf which includes bloating (heavy and uncomfortable feeling in the stomach), nausea, vomiting, and diarrhea, or it could be a symptom of lactic acidosis, a rare and a serious complication of Diagraf.
Q. Can long-term use of Diagraf cause vitamin b12 deficiency?
Yes, Diagraf causes vitamin B12 deficiency on long-term use as it interferes with absorption of vitamin B12 in the stomach. If untreated, it may cause anemia and nerve problems and the patient can have tingling sensation and numbness in hands and feet, weakness, urinary problems, change in mental status and difficulty in making balance (ataxia). To avoid these problems, some researchers suggest an intake of vitamin B12 from outside at least once every year.
Yes, Diagraf is seen to be useful in the management of metabolic syndrome, a collection of risk factors that include high blood pressure, high blood sugar levels, abnormal blood cholesterol levels and excess fat around the waist. Diagraf is an insulin sensitizer and it improves the action of insulin and normalises blood sugar levels and reduces body weight.
Q. How beneficial is it to take Diagraf with glimepiride?
Both Diagraf and glimepiride are anti diabetic drugs and can be used together. They work by different mechanisms and can control the blood sugar levels in a much better way when used together as compared to either drug taken alone. However, glimepiride can cause very low blood glucose levels, so a regular monitoring of blood glucose is very important.
Q. Is it safe to take Diagraf with cetirizine?
Yes, Diagraf can be taken with cetirizine. There are no reported drug interactions or harmful effects when they are used together.
Q. Can I take Diagraf and ranitidine together?
Diagraf can be taken with ranitidine. However, if you are taking them together, you need to monitor blood glucose levels regularly as ranitidine can decrease the removal of Diagraf from the body and increase its blood levels. This can cause very low blood sugar levels and other side effects as well and the dose of Diagraf may need adjustment.
Q. How beneficial is it to take Diagraf with linagliptin?
Both Diagraf and linagliptin are anti-diabetic drugs and can be used together. Their fixed dose combinations are also available and commonly advised once Diagraf is unable to control blood sugar levels even after giving the maximum tolerated dose. As they work by different mechanisms, they help in better control of blood sugar levels compared to either drug taken alone.
Q. Does Diagraf inhibit hepatitis B virus protein?
Yes, some research studies have shown that Diagraf can decrease the multiplication and growth of hepatitis B virus when given along with other antiviral drugs. However, this is indication is still under research and not yet approved.
Diagraf should be temporarily discontinued before chest or any X-ray that requires injection of a contrast medium or dye. These dyes can decrease kidney function and Diagraf along with these dyes can cause a serious side effect like lactic acidosis. So you may need to stop taking Diagraf. However, do not stop taking any medicine without talking to your doctor.
Diagraf can cause sleepiness which could be an early symptom of lactic acidosis along with tiredness, weakness, stomach pain, loose stools, severe muscle pain, muscle cramps and difficulty in breathing. It is a serious condition caused by Diagraf seen in old age patients, those with kidney, liver or heart disease, or those who take large amounts of alcohol. If you have these symptoms, stop taking Diagraf and consult your doctor.
Use of Diagraf is not associated with joint pain. However, diabetes itself decreases blood circulation to the joints and even damages them leading to joint pain. Use of anti-diabetic drugs like sitagliptin or saxagliptin is also associated with joint pain. Early symptoms of lactic acidosis like muscle pain and cramps with weakness and tiredness can be mistaken for joint pain.
Diagraf may be of help in the treatment and prevention of weight gain caused by antipsychotics along with lifestyle modifications like a change in diet and regular exercise. Weight gain is an important reason for discontinuation of these medicines. Diagraf improves insulin sensitivity and prevents weight gain, both of these factors are affected by the use of antipsychotics.
Q. How is gliclazide different from Diagraf?
Both Diagraf and gliclazide are antidiabetic drugs but work in different ways. Diagraf works by decreasing glucose production from liver and decreasing glucose absorption from the gut and increasing insulin sensitivity. Gliclazide works by increasing insulin release from the pancreas. Both control blood sugar levels effectively but Diagraf causes more of stomach upset, like nausea, vomiting, diarrhea and bloating while gliclazide causes low blood sugar levels and weight gain.
Diagraf has shown promising results in some animal research studies in the treatment of fragile X syndrome. It may help in improving mental and behavioral disorders (autism) and control obesity and risk of developing diabetes in these patients. But these results are very preliminary and it is still not approved for the treatment of fragile X syndrome.
Q. What is the difference between liraglutide and Diagraf?
Diagraf and liraglutide are antidiabetic drugs and both control blood sugar levels effectively. Diagraf is taken by oral route and it decreases glucose production from liver and glucose absorption from the gut and increases insulin sensitivity. While liraglutide is an injectable and it increases insulin release from the pancreas. Both cause stomach upset, like nausea, vomiting, diarrhea and bloating while liraglutide also increases the risk of pancreatitis.
No, Diagraf does not elevate the mood or make you feel high. It is an antidiabetic drug used to control high blood sugar levels in newly-diagnosed type 2 diabetes patients, along with modification in diet and exercise. Rare side effects of Diagraf include anxiety and depression.
Yes, sweating is one of the known side effects of Diagraf. The exact cause of this is not known. Some researchers suggest it to be due to low blood sugar levels especially at night which can cause night sweats as well. Monitor your blood sugar levels regularly and talk to your doctor as your dose of Diagraf may need to be adjusted.
Q. Can I take Diagraf with clomiphene citrate?
Diagraf can be taken with clomiphene citrate. They are advised together in patients with infertility along with polycystic ovarian syndrome (PCOS). Clinical studies have shown an improvement in ovulation and pregnancy rates in these patients as compared to use of clomiphene citrate alone or if the patients are resistant to the effects of clomiphene citrate. However, this is still under research.
Diagraf is seen to be useful in the treatment and prevention of cancers especially breast cancer in research studies. As high insulin levels are known to increase the risk of cancer, Diagraf decreases cancer cell growth by decreasing insulin and blood glucose levels. However, its use in treating breast cancer is not yet approved.
No, Diagraf is not associated with an increased risk of Helicobacter pylori infection. Diabetes itself increases the risk of H.pylori infection which increases the chances of stomach upset like nausea, vomiting, diarrhea, and bloating by Diagraf.
Diagraf may decrease the levels of vitamin B12 on long term use which may rarely cause a type of anemia in which blood cells are larger than normal (megaloblastic anemia). You may need to take foods rich in vitamin B12 like eggs, dairy products, and meat or a supplement from outside.
Diagraf is seen to be useful in the management of prediabetes, a condition with blood glucose levels higher than normal but not high enough to label you as diabetic. Diagraf makes the insulin already available in your body to work more effectively, decreases glucose production by liver and increases use of glucose by the muscles and lowers body weight. However, lifestyle modifications like a change in diet and exercise should be tried first as they are seen to be more effective than Diagraf.
Q. Can I take Diagraf with teneligliptin?
Yes, Diagraf can be taken with teneligliptin. It is a good add-on treatment if the blood sugars are very high even after taking Diagraf. The risk of low blood sugar levels (hypoglycemia) is also very low with both the medicines. However, consult your doctor before taking them together as a dose adjustment may be needed.
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