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MD (Pharmacology), MBBS
Last updated on:
19 Aug 2019 | 04:21 PM (IST)
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Chemotinib 400 mg Tablet


Overview

Introduction of Chemotinib Tablet

Chemotinib 400 mg Tablet is used in the treatment of blood cancer (chronic myeloid leukaemia and Acute lymphocytic leukemia) and gastrointestinal stromal tumour.

Chemotinib 400 mg Tablet should be taken in a dose as recommended by the doctor. You should continue to take it as long as your doctor advises for it. The duration of treatment varies according to your need and response to treatment. Your doctor may advice for regular monitoring of blood cells and liver function while your taking this medicine. It is important to inform doctor about all the medications you are taking, including over the counter medicines and dietary supplements.

Water retention and swelling are very common side effects of Chemotinib 400 mg Tablet. Thus, notify your doctor if you have an unexpected rapid weight gain. It may also cause dizziness or blurring of vision, so do not drive or do anything requiring concentration. This medicine may make your skin more sensitive to sun, so it is better to use sunscreen and protective clothing when outdoors. Diarrhea may also occur, so drink plenty of fluids. But, you must inform doctor if it does not stop or you find blood in stools.

Chemotinib Tablet side effects

Common
  • Rash
  • Vomiting
  • Musculoskeletal (bone, muscle or joint) pain
  • Nausea
  • Edema (swelling)
  • Abdominal pain
  • Fatigue
  • Diarrhea
  • Muscle cramp

How to use Chemotinib Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Chemotinib 400 mg Tablet is to be taken with food.

How Chemotinib Tablet works

Chemotinib 400 mg Tablet is an anti-cancer medication. A protein enzyme, bcr-abl tyrosine kinase, responsible for the growth of abnormal proliferation of cancer cells. This medicine inhibits the proliferation and induces apoptosis (planned cell death) in bcr-abl positive cells (cancer cells). This is how it works to stop or slow the spread of cancer.

Chemotinib Tablet related warnings

Alcohol
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Chemotinib 400 mg Tablet. Please consult your doctor.
Pregnancy
CONSULT YOUR DOCTOR
Chemotinib 400 mg Tablet is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
Lactation
CONSULT YOUR DOCTOR
Chemotinib 400 mg Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Lactating women should not breastfeed while using this drug and one month after stopping it.
Driving
UNSAFE
Chemotinib 400 mg Tablet may cause side effects which could affect your ability to drive.
Kidney
CAUTION
Chemotinib 400 mg Tablet should be used with caution in patients with kidney disease. Dose adjustment of Chemotinib 400 mg Tablet may be needed. Please consult your doctor.
Liver
CAUTION
Chemotinib 400 mg Tablet should be used with caution in patients with severe liver disease. Dose adjustment of Chemotinib 400 mg Tablet may be needed. Please consult your doctor.

What if you miss a dose of Chemotinib Tablet?

If you miss a dose of Chemotinib 400 mg Tablet, skip it and continue with your normal schedule. Do not double the dose.

Alternate Brands

For informational purposes only. Consult a doctor before taking any medicines.
Chemotinib 400 mg Tablet
₹84.8/Tablet
Veenat 400 Tablet
Natco Pharma Ltd
₹202.7/Tablet
139% costlier
₹117.6/Tablet
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Imat 400 Tablet
Biochem Pharmaceutical Industries
₹106.4/Tablet
25% costlier
Glivec 400mg Tablet
Novartis India Ltd
₹236.21/Tablet
179% costlier
₹207.28/Tablet
144% costlier

Expert Advice

  • Chemotinib 400 mg Tablet helps in the treatment of blood cancer and stomach tumour.
  • Always take it with food and a full glass of water to prevent nausea.
  • It may cause dizziness or blurred vision. Do not drive or do anything requiring concentration until you know how it affects you.
  • Water retention and swelling are very common side effects of Chemotinib 400 mg Tablet. Notify your doctor if you have unexpected rapid weight gain.
  • Do not change the dose or discontinue use without consulting your doctor.
  • Notify your doctor about all the medications you are taking, including over the counter medicines and dietary supplements.
  • Your doctor may get regular blood tests done to monitor your liver function and the number of blood cells in your blood.

Interaction with Drugs

Taking Chemotinib with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Brand(s): Etovas, Alvastatin, Atalo
SERIOUS
Brand(s): Rosidoc, Rosustin, Rosucad
SERIOUS
Brand(s): Stoin
SERIOUS
Brand(s): Shinosun
SERIOUS
Brand(s): Zuroxy, Roxilim, Rox Thro
MODERATE
Brand(s): Itracip, Itraspan, Itzo
MODERATE

Patient Concerns

Questions Related to Chemotinib

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suggest any medicine to recover from low haemoglobin .I have blood cancer and heart problems too. My haemoglobin remains between 8 - 10 .Suggest me some remedy to rise and maintain the minimum haemoglobin of 12 ?
Dr. Aanchal Maheshwari
Ayurveda
Regularly take kwath of bhuiamla 20 ml twice, tablet abhrlauh 20 ml twice after meal
Medicine for first stage blood cancer
Dr. Deepak Kumar Soni
Skin Specialist
Need to consult face to face , kindly consult to ayurvedic doctor at your local city.
arrow
Do you have any questions related to Chemotinib 400 mg Tablet?

User Feedback


FAQs

Q. Can Chemotinib be taken with food?

Yes, the best way to take it is with a glass of water and food. This prevents irritation in the food pipe and stomach. If you cannot swallow it, put the tablets in a glass of water or apple juice (approximately 50 ml for a 100 mg tablet and 200 ml for a 400 mg tablet). Stir it with a spoon to make it uniform and drink it immediately.

Q. Is it safe to drive while taking Chemotinib?

Chemotinib may cause dizziness, lightheadedness or drowsiness in some people. Make sure you know how you react to it before you drive a car or operate machinery.

Q. What precautions need to be followed while taking Chemotinib?

While taking Chemotinib, make sure you follow all the instructions given by your doctor, carefully and keep all appointments. You will need regular follow-up to ensure that the treatment is working. Regular blood tests, weight checks, and urine tests may be required to find out any side effects before it becomes serious. Make sure you use a method of contraception to prevent pregnancy during treatment with Chemotinib. Tell your doctor immediately if you become pregnant while you are taking this medicine. If you are about to start taking any new medicine, remind your doctor that you are taking Chemotinib.

Q. Ever since I started using Chemotinib, I have noticed that I develop rashes and severe itching when I have sun exposure. Is it because of the medicine or the disease?

This medicine may make your skin much more sensitive to sunlight than it normally is. Exposure to sunlight may cause skin rash, itching, redness or severe sunburn. When you are outdoors, wear protective clothing and use a sunscreen with an SPF of 15 or higher. If you feel a burning sensation on your skin, tell your doctor.

Q. The doctor has advised me not to take any medicine on my own while taking Chemotinib. Should I consult my doctor even if I need to take paracetamol for my fever?

Yes, there are a number of medicines which interfere with Chemotinib, including paracetamol. Therefore you should not self medicate while taking Chemotinib. Other medicines which interfere with Chemotinib include cyclosporin, dexamethasone (a steroid), warfarin, antiviral medicines which treat AIDS and some medicines which treat bacterial infections, high cholesterol, high blood pressure, heart problems, and mental disorders and depression. Consult your doctor before taking any medicine, and inform him that you are on Chemotinib therapy.

Q. What precautions need to be followed while taking Chemotinib?

While taking Chemotinib, make sure you follow all the instructions given by your doctor, carefully and keep all appointments. You will need regular follow-up to ensure that the treatment is working. Regular blood tests, weight checks, and urine tests may be required to find out any side effects before it becomes serious. Make sure you use a method of contraception to prevent pregnancy during treatment with Chemotinib. Tell your doctor immediately if you become pregnant while you are taking this medicine. If you are about to start taking any new medicine, remind your doctor that you are taking Chemotinib.

Q. Can I expect that if I take Chemotinib regularly and as advised by the doctor for CML, I will be cured?

Chemotinib has proved effective in many cases of CML. It is also noticed that the chances of survival increase after taking this medicine. The doctor who is treating CML can tell you better. The doctor will analyze your current state, blood test results, response to treatment, any other medical illness which you may be having, etc. and tell you.

Related Products

Disclaimer: 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover all possible side effects, drug interactions or warnings or alerts. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.
References
  1. Chabner BA, Barnes J, Neal J, et al. Targeted Therapies: Tyrosine Kinase Inhibitors, Monoclonal Antibodies, and Cytokines. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1732-34.
  2. Chu E, Sartorelli AC. Cancer Chemotherapy. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 953.
  3. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 692-94.
  4. Imatinib mesylate. East Hanover, New Jersey: Novartis Pharmaceuticals Corporation; 2001 [revised Jan 2012]. [Accessed 23 Jan. 2019] (online) Available from:External Link
  5. U.S. National Library of Medicine. Imatinib mesylate. [Accessed 26 Mar. 2019] (online) Available from:External Link
  6. Central Drugs Standard Control Organisation (CDSCO). [Accessed 26 Mar. 2019] (online) Available from:External Link
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