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Vinblastine

Information

Uses

Vinblastine is used in the treatment of breast cancer, kidney cancer, Hodgkin’s disease (a cancer of the lymph glands) and non-hodgkin's lymphoma

How it works

Vinblastine blocks replication of genetic material (DNA) in the cancer cells. Thus it stops the growth and multiplication of cancer cells.

Common side effects

Nausea, Vomiting, Decreased appetite, Decreased white blood cell count, Diarrhoea

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Expert advice

  • In males vinblastine may cause aspermia (lack of semen causing infertility); in females vinblastine may cause amenorrhea (absence of menstruation), which may recover after some duration.
  • Take precautions while taking vinblastine as it may cause inflammation of mouth and lips (stomatitis) and neurological toxicity.
  • Avoid even accidental contamination of eyes with vinblastine, as it may cause severe irritation.
  • Vinblastine may cause acute kidney disease (nephropathy) related to uric acid level.
  • Tell your doctor if you are or planning to become pregnant or are breastfeeding.

Frequently asked questions

Vinblastine

Q.

Is vinblastine a vesicant?
Vinblastine is a vesicant (irritant) and can cause damage to the blood vessels if it is not administered properly

Q.

Is vinblastine toxic?
Vinblastine is not toxic, however if given by other route or came in contact with eyes, can cause the harmful effects

Q.

How is vinblastine administered?
Vinblastine is administered by intravenous route only

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Q.

Does vinblastine cause hair loss/infertility?
Vinblastine may cause hair loss/infertility

Q.

Where does vinblastine come from/ what plant does vinblastine come from?
Vinblastine is a plant alkaloid comes from the source called Vinca rosea Linn

Q.

How does vinblastine prevent mitosis?
Vinblastine prevents mitosis by inhibition of microtubule formation.


Content on this page was last updated on 16 February, 2017, by Dr. Varun Gupta (MD Pharmacology)