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Imatib 400 Tablet
Prescription Required
Introduction
Imatib 400 Tablet belongs to the class of medicines known as tyrosine kinase inhibitors. It is used in the treatment of blood cancer (chronic myeloid leukaemia and Acute lymphocytic leukemia) and gastrointestinal stromal tumor.
Imatib 400 Tablet should be taken with food, but better to have it same time every day to get the most benefit. You should continue to take it as long as your doctor advises for it. The duration of treatment varies according to your need and response to treatment. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.
The most common side effects of this medicine include edema, nausea, vomiting, muscle cramps, musculoskeletal pain, diarrhea, rash, fatigue, and abdominal pain. Let your doctor know if you experience unexpected rapid weight gain. Your doctor may advise for regular monitoring of blood cells and liver function while you are taking this medicine. Do not drive or do anything requiring mental focus if you experience dizziness and blurry vision.
Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.
Imatib 400 Tablet should be taken with food, but better to have it same time every day to get the most benefit. You should continue to take it as long as your doctor advises for it. The duration of treatment varies according to your need and response to treatment. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.
The most common side effects of this medicine include edema, nausea, vomiting, muscle cramps, musculoskeletal pain, diarrhea, rash, fatigue, and abdominal pain. Let your doctor know if you experience unexpected rapid weight gain. Your doctor may advise for regular monitoring of blood cells and liver function while you are taking this medicine. Do not drive or do anything requiring mental focus if you experience dizziness and blurry vision.
Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.
Uses of Imatib Tablet
- Blood cancer (Chronic myeloid leukaemia)
- Blood cancer (Acute lymphocytic leukemia)
- Gastrointestinal stromal tumour
Benefits of Imatib Tablet
In Blood cancer (Chronic myeloid leukaemia)
Blood cancer, also called leukemia, is a cancer of the blood-forming tissues, that decreases the body's ability to fight infection. Imatib 400 Tablet kills or stops the growth of cancer cells and also prevents the multiplication of cancer cells. It is a potent and very toxic medicine and you should discuss the risks and benefits with your doctor. You should avoid drinking alcohol while having this treatment and drink plenty of water to stay hydrated.
In Blood cancer (Acute lymphocytic leukemia)
Blood cancer, also called leukemia, is a cancer of the blood-forming tissues, that decreases the body's ability to fight infection. Imatib 400 Tablet kills or stops the growth of cancer cells and also prevents the multiplication of cancer cells. It is a potent and very toxic medicine and you should discuss the risks and benefits with your doctor. You should avoid drinking alcohol while having this treatment and drink plenty of water to stay hydrated.
In Gastrointestinal stromal tumour
A gastrointestinal stromal tumor (GIST) is a type of tumor that occurs most commonly in the stomach or small intestine. The tumors develop into the specialized cells called interstitial cells of Cajal (ICCs). Imatib 400 Tablet helps to kill the cancer cells and also stops their further growth and spread. Follow your doctor’s instructions carefully to get the most benefit.
Side effects of Imatib Tablet
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Imatib
- Edema (swelling)
- Nausea
- Vomiting
- Muscle cramp
- Musculoskeletal (bone, muscle or joint) pain
- Diarrhea
- Rash
- Fatigue
- Abdominal pain
How to use Imatib Tablet
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Imatib 400 Tablet is to be taken with food.
How Imatib Tablet works
Imatib 400 Tablet is an anti-cancer medication. A protein enzyme, bcr-abl tyrosine kinase, responsible for the growth of abnormal proliferation of cancer cells. This medicine inhibits the proliferation and induces apoptosis (planned cell death) in bcr-abl positive cells (cancer cells). This is how it works to stop or slow the spread of cancer.
Safety Advice
Alcohol
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Imatib 400 Tablet. Please consult your doctor.
Pregnancy
CONSULT YOUR DOCTOR
Imatib 400 Tablet is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
Breastfeeding
CONSULT YOUR DOCTOR
Imatib 400 Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Lactating women should not breastfeed while using this drug and one month after stopping it.
Lactating women should not breastfeed while using this drug and one month after stopping it.
Driving
UNSAFE
Imatib 400 Tablet may cause side effects which could affect your ability to drive.
Kidney
CAUTION
Imatib 400 Tablet should be used with caution in patients with kidney disease. Dose adjustment of Imatib 400 Tablet may be needed. Please consult your doctor.
Liver
CAUTION
Imatib 400 Tablet should be used with caution in patients with severe liver disease. Dose adjustment of Imatib 400 Tablet may be needed. Please consult your doctor.
What if you forget to take Imatib Tablet?
If you miss a dose of Imatib 400 Tablet, skip it and continue with your normal schedule. Do not double the dose.
Alternate Brands
For informational purposes only. Consult a doctor before taking any medicines.
Imatib 400 Tablet
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Quick Tips
- Always take it with food and a full glass of water to prevent nausea.
- It may cause dizziness or blurred vision. Do not drive or do anything requiring concentration until you know how it affects you.
- Water retention and swelling are very common side effects of Imatib 400 Tablet. Notify your doctor if you have unexpected rapid weight gain.
- Do not change the dose or discontinue use without consulting your doctor.
- Notify your doctor about all the medications you are taking, including over the counter medicines and dietary supplements.
- Your doctor may get regular blood tests done to monitor your liver function and the number of blood cells in your blood.
Fact Box
Chemical Class
Benzanilides Derivative
Habit Forming
No
Therapeutic Class
ANTI NEOPLASTICS
Interaction with Drugs
Taking Imatib with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Brand(s): Etovas, Alvastatin, Atalo
SERIOUS
Brand(s): Antep, C Lep, Ametol
SERIOUS
Brand(s): Fluvalip, Lescol
SERIOUS
Brand(s): Elstin
SERIOUS
Patient Concerns
Do you have any questions related to Imatib 400 Tablet ?
User Feedback
Patients taking Imatib 400 Tablet
Once A Day
100%
What are you using Imatib Tablet for?
Blood cancer *
80%
Gastrointesti*
10%
Others
10%
*Blood cancer (Chronic myeloid leukaemia), Gastrointestinal stromal tumour
How much was the improvement?
Excellent
64%
Average
25%
Poor
11%
What were the side-effects while using Imatib 400 Tablet?
No Side Effec*
44%
Muscle cramp
17%
Edema (swelli*
11%
Abdominal pai*
6%
Diarrhea
6%
*No Side Effect, Edema (swelling), Abdominal pain
How do you take Imatib Tablet?
With food
83%
With or witho*
11%
Empty stomach
6%
*With or without food
Please rate Imatib 400 Tablet on price
Expensive
67%
Average
22%
Not Expensive
11%
FAQs
Q. Can Imatib 400 Tablet be taken with food?
Yes, the best way to take it is with a glass of water and food. This prevents irritation in the food pipe and stomach. If you cannot swallow it, put the tablets in a glass of water or apple juice (approximately 50 ml for a 100 mg tablet and 200 ml for a 400 mg tablet). Stir it with a spoon to make it uniform and drink it immediately.
Q. Is it safe to drive while taking Imatib 400 Tablet?
Imatib 400 Tablet may cause dizziness, lightheadedness or drowsiness in some people. Make sure you know how you react to it before you drive a car or operate machinery.
Q. What precautions need to be followed while taking Imatib 400 Tablet?
While taking Imatib 400 Tablet, make sure you follow all the instructions given by your doctor, carefully and keep all appointments. You will need regular follow-up to ensure that the treatment is working. Regular blood tests, weight checks, and urine tests may be required to find out any side effects before it becomes serious. Make sure you use a method of contraception to prevent pregnancy during treatment with Imatib 400 Tablet. Tell your doctor immediately if you become pregnant while you are taking this medicine. If you are about to start taking any new medicine, remind your doctor that you are taking Imatib 400 Tablet.
Q. Ever since I started using Imatib 400 Tablet, I have noticed that I develop rashes and severe itching when I have sun exposure. Is it because of the medicine or the disease?
This medicine may make your skin much more sensitive to sunlight than it normally is. Exposure to sunlight may cause skin rash, itching, redness or severe sunburn. When you are outdoors, wear protective clothing and use a sunscreen with an SPF of 15 or higher. If you feel a burning sensation on your skin, tell your doctor.
Q. The doctor has advised me not to take any medicine on my own while taking Imatib 400 Tablet. Should I consult my doctor even if I need to take paracetamol for my fever?
Yes, there are a number of medicines which interfere with Imatib 400 Tablet, including paracetamol. Therefore you should not self medicate while taking Imatib 400 Tablet. Other medicines which interfere with Imatib 400 Tablet include cyclosporin, dexamethasone (a steroid), warfarin, antiviral medicines which treat AIDS and some medicines which treat bacterial infections, high cholesterol, high blood pressure, heart problems, and mental disorders and depression. Consult your doctor before taking any medicine, and inform him that you are on Imatib 400 Tablet therapy.
Q. What precautions need to be followed while taking Imatib 400 Tablet?
While taking Imatib 400 Tablet, make sure you follow all the instructions given by your doctor, carefully and keep all appointments. You will need regular follow-up to ensure that the treatment is working. Regular blood tests, weight checks, and urine tests may be required to find out any side effects before it becomes serious. Make sure you use a method of contraception to prevent pregnancy during treatment with Imatib 400 Tablet. Tell your doctor immediately if you become pregnant while you are taking this medicine. If you are about to start taking any new medicine, remind your doctor that you are taking Imatib 400 Tablet.
Q. Can I expect that if I take Imatib 400 Tablet regularly and as advised by the doctor for CML, I will be cured?
Imatib 400 Tablet has proved effective in many cases of CML. It is also noticed that the chances of survival increase after taking this medicine. The doctor who is treating CML can tell you better. The doctor will analyze your current state, blood test results, response to treatment, any other medical illness which you may be having, etc. and tell you.
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Disclaimer:
1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover all possible side effects, drug interactions or warnings or alerts. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.References
- Chabner BA, Barnes J, Neal J, et al. Targeted Therapies: Tyrosine Kinase Inhibitors, Monoclonal Antibodies, and Cytokines. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1732-34.
- Chu E, Sartorelli AC. Cancer Chemotherapy. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 953.
- Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 692-94.
- Imatinib mesylate. East Hanover, New Jersey: Novartis Pharmaceuticals Corporation; 2001 [revised Jan 2012]. [Accessed 23 Jan. 2019] (online) Available from:
- Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Imatinib. [Updated 2018 Oct 31]. [Accessed 18 Feb. 2020] (online) Available from:
- Central Drugs Standard Control Organisation (CDSCO). [Accessed 26 Mar. 2019] (online) Available from:
Manufacturer/Marketer Address
Cipla House, Peninsula Business Park, Ganpatrao Kadam Marg, Lower Parel, Mumbai-400013
Country of Origin: India
Expires on or after: February, 2022
A licensed vendor partner from your nearest location will deliver Imatib 400 Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.
Expires on or after: February, 2022
A licensed vendor partner from your nearest location will deliver Imatib 400 Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.
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