Biotrexate 1000mg Injection
Prescription Required
Product introduction
Biotrexate 1000mg Injection is a medicine used for treatment of cancer in various parts of the body such as breasts, head, neck, lungs, blood, bone, lymph, and uterus. It may be used with other medicines as part of combination therapy.
Biotrexate 1000mg Injection is given under the supervision of a healthcare professional and should not be self-administered. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. You should avoid drinking alcohol as it may increase your risk of liver damage.
The most common side effects of this medicine include nausea, vomiting, loss of appetite, abdominal pain, tiredness, mouth sores, and decreased white blood cells. Your doctor may advise you to take folic acid to reduce some of these. If they do not go away or get worse, tell your doctor. There may be ways of preventing or reducing these effects. It is a very strong medicine and some people may develop serious side effects while taking it. This medicine may lower your ability to fight infections and lead to problems with your blood, liver or kidneys. Your doctor will advise you regular blood tests to check for these.
Before taking it, tell your doctor if have stomach, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. It may harm your baby. You and your partner should avoid becoming pregnant or fathering a child for several months after your treatment with it has stopped. Your doctor may perform several tests such as blood tests, X-rays and physical examinations both before and during treatment with this medicine.
Biotrexate 1000mg Injection is given under the supervision of a healthcare professional and should not be self-administered. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. You should avoid drinking alcohol as it may increase your risk of liver damage.
The most common side effects of this medicine include nausea, vomiting, loss of appetite, abdominal pain, tiredness, mouth sores, and decreased white blood cells. Your doctor may advise you to take folic acid to reduce some of these. If they do not go away or get worse, tell your doctor. There may be ways of preventing or reducing these effects. It is a very strong medicine and some people may develop serious side effects while taking it. This medicine may lower your ability to fight infections and lead to problems with your blood, liver or kidneys. Your doctor will advise you regular blood tests to check for these.
Before taking it, tell your doctor if have stomach, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. It may harm your baby. You and your partner should avoid becoming pregnant or fathering a child for several months after your treatment with it has stopped. Your doctor may perform several tests such as blood tests, X-rays and physical examinations both before and during treatment with this medicine.
Uses of Biotrexate Injection
Benefits of Biotrexate Injection
In Cancer
Biotrexate 1000mg Injection belongs to a group of medicines called antimetabolites and is referred to as a cytotoxic. It works by slowing the growth of cancer cells in the body. It is used to treat a wide range of cancers such as acute leukemias, non-Hodgkin’s lymphoma, and solid tumors found in breast, lung, bladder, head and neck as well as cervical, ovarian and testicular cancer. It may be given alone or in combination with other medicines. It is a potent and very toxic medicine and you should discuss the risks and benefits with your doctor. You should avoid drinking alcohol while having this treatment and drink plenty of water to stay hydrated.
In Treatment of Rheumatoid arthritis
Biotrexate 1000mg Injection belongs to a group of medicines called antimetabolites. It may be used to treat severe rheumatoid arthritis if other treatments have already been tried and have not worked. It is not a first-line treatment. It works by reducing the body's immune system, this decreases swelling, reduces pain, stiffness, and improves function. Take it exactly as prescribed and for as long as it is prescribed to get the most benefit. Do not take more than you should. It may take several months to become fully effective.
Side effects of Biotrexate Injection
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Biotrexate
- Abdominal pain
- Indigestion
- Loss of appetite
- Nausea
- Vomiting
- Tiredness
- Mouth sore
- Decreased white blood cell count
How to use Biotrexate Injection
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Biotrexate Injection works
Biotrexate 1000mg Injection is an anti-cancer medication. It works by blocking an enzyme (dihydrofolate reductase) involved in DNA synthesis in cancer cells. This slows the growth of cancer cells and eventually kills them.
Safety advice
Alcohol
CAUTION
Caution is advised when consuming alcohol with Biotrexate 1000mg Injection. Please consult your doctor.
Pregnancy
UNSAFE
Biotrexate 1000mg Injection is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.
Breast feeding
UNSAFE
Biotrexate 1000mg Injection is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
Driving
UNSAFE
Biotrexate 1000mg Injection may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney
CAUTION
Biotrexate 1000mg Injection should be used with caution in patients with kidney disease. Dose adjustment of Biotrexate 1000mg Injection may be needed. Please consult your doctor.
Regular monitoring of kidney function test is advised while you are taking this medicine.
Regular monitoring of kidney function test is advised while you are taking this medicine.
Liver
CAUTION
Biotrexate 1000mg Injection should be used with caution in patients with liver disease. Dose adjustment of Biotrexate 1000mg Injection may be needed. Please consult your doctor.
Use of Biotrexate 1000mg Injection is not recommended in patients with severe liver disease.
Use of Biotrexate 1000mg Injection is not recommended in patients with severe liver disease.
What if you forget to take Biotrexate Injection?
If you miss a dose of Biotrexate 1000mg Injection, consult your doctor.
All substitutes
For informational purposes only. Consult a doctor before taking any medicines.
Biotrexate 1000mg Injection
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Quick tips
- Biotrexate 1000mg Injection helps treat various types of cancer such as blood cancer, bone cancer, non-Hodgkin lymphoma (NHL), breast cancer, lung cancer, head and neck cancer, cervical cancer, ovarian cancer and testicular cancer.
- Take it once a week, on the same day every week.
- Always take folic acid as advised by your doctor. This will help lessen the side effects of this medicine.
- Drink plenty of liquids to stay hydrated while taking this medication.
- It may take 6 to 8 weeks for Biotrexate 1000mg Injection to work. Keep taking the medication as prescribed.
- Avoid drinking alcohol while taking this medicine as it may increase the risk of side effects.
- It can be harmful to an unborn baby. Avoid pregnancy for at least 6 months after your last dose.
- Your doctor may get regular blood test done to monitor your kidney function, liver function and level of blood cells in your blood.
Fact Box
Chemical Class
Glutamic Acid Derivative
Habit Forming
No
Therapeutic Class
ANTI NEOPLASTICS
Action Class
Antimetabolite- Methotrexate
Interaction with drugs
Taking Biotrexate with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Concurrent use may cause a decrease in the ability of the bone marrow to produce blood cells.
Do not consume Methotrexate from 1 day before until 1 day after taking Molgramostim.
Concurrent use may cause a decrease in the ability of the bone marrow to produce blood cells.
Do not consume Lenograstim from 24 hours before until 24 hours after undergoing cytot
Concurrent use may cause a decrease in the ability of the bone marrow to produce blood cells.
Do not consume Methotrexate from 1 day before until 1 day after taking Sargramostim.
Concurrent use may increase the risk of kidney impairment. Amphotericin B may slow down the removal of Methotrexate from the body.
If concurrent use is essential, please consult yo
Concurrent use may cause a decrease in the ability of the bone marrow to produce blood cells.
Do not consume Filgrastim from 24 hours before and until 24 hours after taking Methot
Patient concerns
FAQs
Can Biotrexate 1000mg Injection cause mouth ulcers?
Yes, Biotrexate 1000mg Injection can cause a sore mouth and mouth ulcers as side effects in some cases. Taking folic acid along with this medicine may help in reducing the ulcers. Ask your doctor if the dose can be reduced as dose reduction may further help in reducing the ulcers.
Why do I have to take folic acid with Biotrexate 1000mg Injection?
Biotrexate 1000mg Injection decreases the folic acid levels in the body by flushing it out of the body. Folic acid is an essential vitamin required to make new cells in the body. By taking folic acid some of the common side effects of Biotrexate 1000mg Injection like mouth ulcers, hair loss, nausea, heartburn, abdominal pain, fatigue, anemia and liver problems can be reduced.
Why do I need to take regular blood tests while taking Biotrexate 1000mg Injection?
Regular blood tests will help your doctor to check your response to Biotrexate 1000mg Injection and monitor your side effects. You will need to routinely check your liver function and your blood counts (white blood cells, red blood cells and platelets). Your doctor may also advise additional tests depending on the previous test results.
Can Biotrexate 1000mg Injection use make me more prone to infections?
Biotrexate 1000mg Injection may decrease the activity of your immune system. As a result, you may develop serious infections. There have been rare reports of serious lung infections with Biotrexate 1000mg Injection use. If you have an active infection, Biotrexate 1000mg Injection should be used with extreme caution.
Can Biotrexate 1000mg Injection affect fertility?
Yes, it may affect fertility in both males and females. There may be a decrease in sperm count in males and menstrual disturbances in females. Do not worry, these effects are reversible and disappear once the therapy is discontinued. However, if you have more concerns, consult your doctor.
What to do if I am planning to become pregnant and my husband is taking Biotrexate 1000mg Injection?
You should avoid pregnancy if your husband is taking Biotrexate 1000mg Injection. Also, avoid pregnancy for a minimum of 3 months after the therapy as it can lead to serious fetal abnormalities.
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Disclaimer:
Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.References
- Chu E, Sartorelli AC. Cancer Chemotherapy. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 944-46.
- Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 887-90.
- Methotrexate. Camberley, Surrey: Sandoz Limited; 2005 [revised 23 Mar. 2018]. [Accessed 24 Jan. 2019] (online) Available from:
- Methotrexate. Lake Forest, Illinois: Hospira, Inc.; 2011. [Accessed 26 Mar. 2019] (online) Available from:
- Methotrexate [Product Information]. Taj Pharma. [Accessed 04 Aug. 2023]. (online) Available from:
- Methotrexate [New Zealand Data Sheet]. Auckland, New Zealand: Novartis New Zealand Ltd; 2023. [Accessed 04 Aug. 2023]. (online) Available from:
Marketer details
Name: Biochem Pharmaceutical Industries
Address: BIOCHEM PHARMA, LG 113 / A, Xth Central Mall, Mahavir Nagar, 90ft Road, Next to D Mart, Kandivali - West, Mumbai - 400067.
Country of origin: India
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₹1016
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1.0 Injection in 1 vial
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