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Methocel 1000mg Injection

Methotrexate (1000mg)

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Methocel 1000mg Injection is a medicine used for treatment of cancer in various parts of the body such as breasts, head, neck, lungs, blood, bone, lymph, and uterus. It may be used with other medicines as part of combination therapy.

Written By Dr. Sakshi Jain, MS, BDS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 25 Nov 2025 | 03:05 PM (IST)

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10 ml Injection

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General Information

Contains

Methotrexate (1000mg)

Marketer

Celon Laboratories Ltd

Storage

Store below 30°C

The content is shown in English

Product introduction

Methocel 1000mg Injection is given under the supervision of a healthcare professional and should not be self-administered. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. You should avoid drinking alcohol as it may increase your risk of liver damage.

The most common side effects of this medicine include nausea, vomiting, loss of appetite, abdominal pain, tiredness, mouth sores, and decreased white blood cells. Your doctor may advise you to take folic acid to reduce some of these. If they do not go away or get worse, tell your doctor. There may be ways of preventing or reducing these effects. It is a very strong medicine and some people may develop serious side effects while taking it. This medicine may lower your ability to fight infections and lead to problems with your blood, liver or kidneys. Your doctor will advise you regular blood tests to check for these.

Before taking it, tell your doctor if have stomach, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. It may harm your baby. You and your partner should avoid becoming pregnant or fathering a child for several months after your treatment with it has stopped. Your doctor may perform several tests such as blood tests, X-rays and physical examinations both before and during treatment with this medicine.

Uses of Methocel Injection

Benefits of Methocel Injection

Cancer
Methocel 1000mg Injection belongs to a group of medicines called antimetabolites and is referred to as a cytotoxic. It works by slowing the growth of cancer cells in the body. It is used to treat a wide range of cancers such as acute leukemias, non-Hodgkin’s lymphoma, and solid tumors found in breast, lung, bladder, head and neck as well as cervical, ovarian and testicular cancer. It may be given alone or in combination with other medicines. It is a potent and very toxic medicine and you should discuss the risks and benefits with your doctor. You should avoid drinking alcohol while having this treatment and drink plenty of water to stay hydrated.

Treatment of Rheumatoid arthritis
Methocel 1000mg Injection belongs to a group of medicines called antimetabolites. It may be used to treat severe rheumatoid arthritis if other treatments have already been tried and have not worked. It is not a first-line treatment. It works by reducing the body's immune system, this decreases swelling, reduces pain, stiffness, and improves function. Take it exactly as prescribed and for as long as it is prescribed to get the most benefit. Do not take more than you should. It may take several months to become fully effective.

Side effects of Methocel Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Methocel

Abdominal pain
Indigestion
Loss of appetite
Nausea
Vomiting
Tiredness
Mouth sore
Decreased white blood cell count

How to use Methocel Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Methocel Injection works

Methocel 1000mg Injection is an anti-cancer medication. It works by blocking an enzyme (dihydrofolate reductase) involved in DNA synthesis in cancer cells. This slows the growth of cancer cells and eventually kills them.

All substitutes for Methocel 1000mg Injection

For information purposes only. Consult a doctor before taking any medicine.

Trexova 1g Injection

by Neova Biogene Private Limited

₹2018/injection

123% costlier

Plastomet 1000mg Injection

by Khandelwal Laboratories Pvt Ltd

₹1875/injection

107% costlier

Quick tips

Methocel 1000mg Injection helps treat various types of cancer such as blood cancer, bone cancer, non-Hodgkin lymphoma (NHL), breast cancer, lung cancer, head and neck cancer, cervical cancer, ovarian cancer and testicular cancer.
Take it once a week, on the same day every week.
Always take folic acid as advised by your doctor. This will help lessen the side effects of this medicine.
Drink plenty of liquids to stay hydrated while taking this medication.
It may take 6 to 8 weeks for Methocel 1000mg Injection to work. Keep taking the medication as prescribed.
Avoid drinking alcohol while taking this medicine as it may increase the risk of side effects.
It can be harmful to an unborn baby. Avoid pregnancy for at least 6 months after your last dose.
Your doctor may get regular blood test done to monitor your kidney function, liver function and level of blood cells in your blood.

Safety advice

Alcohol

CAUTION

Alcohol should be used with caution while taking Methocel 1000mg Injection.

Pregnancy

UNSAFE

Methocel 1000mg Injection is highly unsafe during pregnancy. It can cause serious harm to the unborn baby, including birth defects and pregnancy loss. Do not use this medicine if you are pregnant or planning to become pregnant.

Breast feeding

UNSAFE

Methocel 1000mg Injection is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

Driving

UNSAFE

Methocel 1000mg Injection may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Kidney

CAUTION

Methocel 1000mg Injection should be used with caution in patients with kidney disease. Dose adjustment may be needed.
Regular monitoring of kidney function test is advised while you are taking this medicine.

Liver

CAUTION

Methocel 1000mg Injection should be used with caution in patients with liver disease. Dose adjustment may be needed.
Use of Methocel 1000mg Injection is not recommended in patients with severe liver disease.

Interaction with drugs

Taking Methocel with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Severe

Filgrastim (Injection Route)

Do not consume Filgrastim from 24 hours before or 24 hours after taking Methotrexate. Please consult with your doctor. Methotrexate may reduce the efficacy of Filgrastim.

Severe

Sargramostim (Injection Route)

Do not consume Methotrexate from 1 day before until 1 day after taking Sargramostim. Please consult your doctor.

Severe

Lenograstim (Injection Route)

Do not consume Lenograstim from 24 hours before until 24 hours after undergoing cytotoxic chemotherapy.

Severe

Molgramostim (Injection Route)

Do not consume Methotrexate from 1 day before until 1 day after taking Molgramostim. Please consult your doctor.

Severe

Aceclofenac (Oral Route)

Please consult with your doctor. Doctor may monitor liver function and blood cell counts.

Frequently asked questions

Can Methocel 1000mg Injection cause mouth ulcers?

Yes, Methocel 1000mg Injection can cause a sore mouth and mouth ulcers as side effects in some cases. Taking folic acid along with this medicine may help in reducing the ulcers. Ask your doctor if the dose can be reduced as dose reduction may further help in reducing the ulcers.

Why do I have to take folic acid with Methocel 1000mg Injection?

Methocel 1000mg Injection decreases the folic acid levels in the body by flushing it out of the body. Folic acid is an essential vitamin required to make new cells in the body. By taking folic acid some of the common side effects of Methocel 1000mg Injection like mouth ulcers, hair loss, nausea, heartburn, abdominal pain, fatigue, anemia and liver problems can be reduced.

Why do I need to take regular blood tests while taking Methocel 1000mg Injection?

Regular blood tests will help your doctor to check your response to Methocel 1000mg Injection and monitor your side effects. You will need to routinely check your liver function and your blood counts (white blood cells, red blood cells and platelets). Your doctor may also advise additional tests depending on the previous test results.

Can Methocel 1000mg Injection use make me more prone to infections?

Methocel 1000mg Injection may decrease the activity of your immune system. As a result, you may develop serious infections. There have been rare reports of serious lung infections with Methocel 1000mg Injection use. If you have an active infection, Methocel 1000mg Injection should be used with extreme caution.

Can Methocel 1000mg Injection affect fertility?

Yes, it may affect fertility in both males and females. There may be a decrease in sperm count in males and menstrual disturbances in females. Do not worry, these effects are reversible and disappear once the therapy is discontinued. However, if you have more concerns, consult your doctor.

What to do if I am planning to become pregnant and my husband is taking Methocel 1000mg Injection?

You should avoid pregnancy if your husband is taking Methocel 1000mg Injection. Also, avoid pregnancy for a minimum of 3 months after the therapy as it can lead to serious fetal abnormalities.

Fact Box

Chemical Class

Glutamic acid derivative

Habit Forming

Therapeutic Class

ANTI NEOPLASTICS

Action Class

Antimetabolite- Methotrexate

Related lab tests

Rheumatoid Factor - Agglutination

Rheumatoid Factor - Turbidometry

Rheumatoid Factor IgG Antibody

References

Chu E, Sartorelli AC. Cancer Chemotherapy. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 944-46.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 887-90.
Methotrexate. Camberley, Surrey: Sandoz Limited; 2005 [revised 23 Mar. 2018]. [Accessed 24 Jan. 2019] (online) Available from:
Methotrexate. Lake Forest, Illinois: Hospira, Inc.; 2011. [Accessed 26 Mar. 2019] (online) Available from:
Methotrexate [Product Information]. Taj Pharma. [Accessed 04 Aug. 2023]. (online) Available from:
Methotrexate [New Zealand Data Sheet]. Auckland, New Zealand: Novartis New Zealand Ltd; 2023. [Accessed 04 Aug. 2023]. (online) Available from:

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Cancer

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Celon Laboratories Ltd
Address: Plot No 264, Patrika Nagar Madhapur, Hitech City Hyderabad, Telangana India - 500081

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Methocel 1000mg Injection. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

Lab tests offered by us

Why we need a prescription?

Methocel 1000mg Injection

Cash on delivery

Free Return

Expiry after

Save more with additional offers

General Information

Contains

Marketer

Storage

Product introduction

Uses of Methocel Injection

Benefits of Methocel Injection

Side effects of Methocel Injection

How to use Methocel Injection

How Methocel Injection works

All substitutes for Methocel 1000mg Injection

Trexova 1g Injection

Plastomet 1000mg Injection

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Filgrastim (Injection Route)

Sargramostim (Injection Route)

Lenograstim (Injection Route)

Molgramostim (Injection Route)

Aceclofenac (Oral Route)

Frequently asked questions

Can Methocel 1000mg Injection cause mouth ulcers?

Why do I have to take folic acid with Methocel 1000mg Injection?

Why do I need to take regular blood tests while taking Methocel 1000mg Injection?

Can Methocel 1000mg Injection use make me more prone to infections?

Can Methocel 1000mg Injection affect fertility?

What to do if I am planning to become pregnant and my husband is taking Methocel 1000mg Injection?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

Related lab tests

Rheumatoid Factor - Agglutination

Rheumatoid Factor - Turbidometry

Rheumatoid Factor IgG Antibody

References

User feedback

What are you using Methocel Injection for?

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

In case of any issues, contact us

Lab tests offered by us

Related/Popular tests