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18 Feb 2020 | 05:25 PM (IST)
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Azotas 50mg Tablet


Overview

Introduction

Azotas 50mg Tablet belongs to a group of medicines called immunosuppressants. It is used with other medicines to prevent your body rejecting an organ (such as a kidney, heart or liver) after a transplant. It works by weakening your body’s immune system, so it does not attack the new organ.

The amount of Azotas 50mg Tablet to be taken and how often you need to take it will depend on the type of transplant you have. Follow your doctor’s instructions on this. You should take it along with food. Swallow it as a whole,  do not crush, chew, break, or open them. Take the medicine regularly to get the most benefit and keep taking it even if you feel well. If you stop taking it, you may increase the chances of rejecting your transplanted organ. The treatment will continue for as long as you need it to prevent rejection.

It has many potential side effects. The most common are loss of appetite, nausea and increased risk of bleeding. Because it suppresses your immune system, you may catch more infections than usual. There’s also an increased risk of developing some cancers for this reason. To reduce your risk of skin cancer, limit your exposure to the sun and use a protective cream. There is a long list of potential side effects. You should ask your doctor about them and what signs to look out for because some can be serious and need urgent medical attention.

Azotas 50mg Tablet can cause birth defects and miscarriages so do not take it if you are pregnant, planning to become pregnant or breastfeeding. You should talk to your doctor before taking this medicine if you have any signs of infection or if you have any unexpected bruising or bleeding. Your doctor also needs to know what other medicines you are taking as there are many which interact with this medicine and affect the way it works. You will have regular tests to check for any changes in the number of your blood cells.

Side effects of Azotas Tablet

Common
  • Decreased white blood cell count
  • Increased bleeding tendency
  • Nausea
  • Infection
  • Loss of appetite

How to cope with side effects?

The occurrence of side effects varies from person to person. The following are a few ways of dealing with some of the common side effects. However, consult your doctor if these persist.

  • Coping with Decreased white blood cell count and Infection
    If you have a low level of white blood cells, you are more likely to get infections. There are several ways to reduce your chances of catching or spreading an infection. Avoid unnecessary exposure to germs when you can. Wash your hands frequently and thoroughly with soap or use a sanitiser. Avoid crowds and avoid contact with people who are ill or have infections. Use disposable tissues for coughs and sneezes. Consider using an appropriate face mask. Do not share personal items like cutlery, glasses, towels or toothbrushes with others. Get enough rest and eat a well balanced healthy diet.
  • Coping with Increased bleeding tendency
    Hold a gauze over the area that is bleeding and apply pressure. Holding an ice pack to bruises may make them fade more quickly. Seek emergency help if you are bleeding profusely or if the bleeding doesn’t stop within 15 minutes. If you are bleeding more easily than normal, try to be careful when doing activities that might cause an injury or a cut, as it may take longer to stop bleeding. Use a soft toothbrush and waxed dental floss to clean your teeth. See a doctor if you're worried about any bleeding.
  • Coping with Nausea
    You can help yourself by eating small, frequent meals rather than large ones and drinking plenty of fluids. Eat slowly. Avoid fatty, fried, spicy and very sweet foods. Eat cold or slightly warm food if the smell of cooked or cooking food makes you feel sick. Get plenty of fresh air. You could also try chewing ginger or drinking ginger tea. Eat bananas to replace potassium in your blood which can drop if you are sick (vomit). Use oral rehydration salts to replace vitamins and minerals lost through being sick. There are some medicines that can help you stop from feeling sick. Speak to your doctor if your condition does not improve.
  • Coping with Loss of appetite
    It is important to eat, even if you do not feel like it. You might try switching to smaller meals and frequent snacks. Try eating healthy and nutritious snacks that are high in calories and protein, such as dried fruit and nuts. It is important to drink even if you cannot eat. But, do not fill your stomach with liquid before eating. Eat when you are most hungry. Exercise such as a short walk may also increase your appetite. Talk to your doctor about possible medication or supplements if your condition does not improve.

How to use Azotas Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Azotas 50mg Tablet is to be taken with food.

How Azotas Tablet works

Azotas 50mg Tablet is an immunosuppressant. It reduces the action of body's own defense system (the immune system) and prevents rejection of the transplanted organ. It also blocks the action of certain chemical messengers that are responsible for inflammation, swelling, and redness associated with certain joint diseases.

Safety Advice

Alcohol
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Azotas 50mg Tablet. Please consult your doctor.
Pregnancy
CONSULT YOUR DOCTOR
Azotas 50mg Tablet is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
Breastfeeding
CONSULT YOUR DOCTOR
Azotas 50mg Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Driving
CONSULT YOUR DOCTOR
It is not known whether Azotas 50mg Tablet alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.
Kidney
CAUTION
Azotas 50mg Tablet should be used with caution in patients with kidney disease. Dose adjustment of Azotas 50mg Tablet may be needed. Please consult your doctor.
Use of Azotas 50mg Tablet is not recommended in patients with serious kidney disease.
Liver
CAUTION
Azotas 50mg Tablet should be used with caution in patients with liver disease. Dose adjustment of Azotas 50mg Tablet may be needed. Please consult your doctor.
Use of Azotas 50mg Tablet is not recommended in patients with severe liver disease. Regular monitoring of liver function tests is advisable while you are taking this medicine.

Alternate Brands

For informational purposes only. Consult a doctor before taking any medicines.
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Quick Tips

  • Your doctor has prescribed Azotas 50mg Tablet to stop the body from rejecting a transplanted organ (e.g. kidney, heart or liver).
  • Azotas 50mg Tablet also relieves joint pain and inflammation in rheumatoid arthritis.
  • You may have to take additional medications along with Azotas 50mg Tablet for better relief of symptoms.
  • Avoid contact with people who have cold, flu or other contagious illness. Notify your doctor if you have any signs of infection such as a fever or sore throat.
  • Inform your doctor if you are pregnant or planning to conceive or breastfeeding.

Interaction with Drugs

Taking Azotas with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Brand(s): Lefsum, Lefunid, Lefumide
LIFE-THREATENING
Brand(s): Rotasiil, Rotarix, RotaTeq
LIFE-THREATENING
LIFE-THREATENING
Brand(s): Abhay M
LIFE-THREATENING

Patient Concerns

arrow
ILD affected by Juvinle rheumatoid arthritis? After Lung transplant again may affected ILD because of arthritis?
Dr. Anshum Aneja Arora
Pulmonology
Yes ild can occur due to arthritis . Lung transplant is last procedure for uncontrollable disease. Medicines may control stmptoms
Rheumatoid arthritis diseases attack Rheumatoid arthritis diseases tablet for this
Vipul Aggarwal
please consult rheumatologist for the same
arrow
Do you have any questions related to Azotas 50mg Tablet ?

FAQs

Q. What is Azotas prescribed for? How does it work?

Azotas is an immunosuppressant which means that it acts by suppressing the immune defense system of the body. Your immune defense system helps to protect you against infections. However, sometimes your immune defense system can become overactive and can cause illness. Azotas is used in combination with other medicines to treat the conditions caused due to this abnormal activity of the immune system. It is used to prevent rejection of transplanted organs, like the kidney, heart or liver. It is also used to treat chronic active hepatitis, severe rheumatoid arthritis, systemic lupus erythematosus (SLE), idiopathic thrombocytopenic purpura and acquired hemolytic anemia. It is also used to treat severe cases of specified skin diseases (pemphigus vulgaris, dermatomyositis, polyarteritis nodosa, pyoderma gangrenosa), especially when corticosteroids cannot be used.

Q. How long does Azotas take to start working?

It may take about 3 to 12 weeks before you see any benefits. Continue the medication even if you do not notice any benefits. Talk to your doctor if you face any issues.

Q. What happens if I forget to take Azotas?

If you miss a dose of Azotas, take it as soon as you remember. However, skip the missed dose if it is time for your next dose. Do not take a double dose to compensate for the missed dose. inform your doctor if the dose is frequently missed.

Q. How long do I need to take Azotas?

The duration varies from person to person as it is prescribed depending upon the patient’s medical condition.

Q. Is breastfeeding safe during Azotas treatment?

No, breastfeeding should be avoided, while on Azotas, since it may harm the baby and cause serious side effects.

Q. I have just started taking Azotas. What are the long-term side effects? Is there anything I should be looking out for?

Being an immunosuppressant, Azotas can increase the chances of severe infections, decrease in blood cell counts, and malignancy. You should inform your doctor immediately if you notice any infection or fever, unexpected bruising or bleeding, black tarry stools or blood in the urine or stools. Let your doctor know if you notice any new skin sore or lump, new marks on skin or any change in the marks which were previously present.

Q. Do I need any special tests while I am on Azotas?

Azotas reduces the production of blood cells making you more vulnerable to infections and can sometimes affect the liver. These side effects can be monitored by regular blood tests. Therefore, during the first 8 weeks of the treatment your doctor may recommend weekly blood tests to monitor complete blood counts, including platelet counts. The frequency can later be reduced to monthly or at least once in 3 months time.

Q. Can Azotas cause cancer?

Azotas may increase the chance of developing certain cancers like skin cancer, cancer of the lymph system (lymphoma), cancer of soft tissues (sarcomas), and cervical cancer. To prevent the risk of skin cancer, avoid prolonged exposure to sunlight and wear protective clothing, sunglasses, and sunscreen. Tell your doctor immediately if you notice any changes in your skin or any lumps or masses anywhere on your body.

Q. Can cyclosporine and Azotas be taken together?

Yes, you can take cyclosporine and Azotas together as they do not interfere with each other’s working. However, you must take the two medicines strictly as per your doctor’s advice.

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Disclaimer: 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover all possible side effects, drug interactions or warnings or alerts. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.
References
  1. Krensky AM, Bennett WM, Vincenti F. Immunosuppressants, Tolerogens, and Immunostimulants. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. New York, New York: McGraw-Hill Medical; 2011. pp. 1013-14.
  2. Furst DE, Ulrich RW, Varkey-Altamirano C. Nonsteroidal Anti-Inflammatory Drugs, Disease Modifying Antirheumatic Drugs, Nonopioids Analgesics, & Drugs Used in Gout. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 629-30.
  3. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. p. 113-15.
  4. Azathioprine. Barnstaple, Devon: Actavis UK Limited; 2018. [Accessed 05 Feb. 2019] (online) Available from:External Link
  5. Azathioprine. San Diego, California: Prometheus Laboratories Inc.; 2014. [Accessed 06 Apr. 2019] (online) Available from:External Link
  6. Chaves RG, Lamounier JA. Breastfeeding and maternal medications. J Pediatr (Rio J). 2004;80(5 Suppl):S189-S198. [Accessed 03 Apr. 2019] (online) Available from:External Link
  7. Azathioprine. Dartford, UK: Ennogen Pharma Ltd.; 2009 [revised 29 Jun. 2016]. [Accessed 17 Jun. 2019] (online) Available from:External Link
  8. Oxford Radcliffe Hospitals: NHS Trust. Azathioprine - General Information; 2012. [Accessed 17 Jun. 2019]. (online) Available from:External Link
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