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Pegfilgrastim is used to prevent infections after chemotherapy

How it works

Pegfilgrastim is a growth factor that stimulates the bone marrow to produce white blood cells. These cells protect the body against infections. .

Common side effects

Bone pain, Joint pain, Headache, Nausea, Reduced blood platelets, Muscle pain, Back pain, Pain in extremity, Injection site pain

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Expert advice

  • Avoid traveling, driving or operating machinery for about 30 hours following application of the on-body injector (a small device stuck to your body to assist administration of pegfilgrastim).
  • You should be frequently examined for complete blood count (including differential white cell and platelet count) and spleen size during treatment.
  • Seek immediate medical attention if you experience pain in the left upper abdomen or shoulder after receiving pegfilgrastim, this may indicate development of a serious side effect associated with spleen (spleen rupture).
  • Discontinue pegfilgrastim if you develop fever, any signs or symptoms of infection, rash, flushing, dizziness or shortness of breath and severe lung injury along with migration of neutrophils into the lungs (acute respiratory distress).
  • Tell your doctor if you have sickle cell anemia, if you are allergic to latex or had severe skin reactions to acrylic adhesives before receiving pegfilgrastim.
  • Tell your doctor if you are pregnant or planning to become pregnant or are breastfeeding.

Frequently asked questions



Is pegfilgrastim a chemo drug/ What is pegfilgrastim injection/ How is pegfilgrastim given?
Pegfilgrastim belongs to a class of medications called colony stimulating factors. It helps reduce the chances of infections and side effects related to chemotherapy and does not directly treat cancer. Pegfilgrastim comes as a solution (liquid) to inject subcutaneously (under the skin), 24 hours after chemotherapy. It may be injected by a doctor/nurse in a hospital or you may be shown how to use injections at home


How does pegfilgrastim work?
Pegfilgrastim belongs to a class of medications called colony stimulating factors. It acts on hematopoietic cells (cells in the bone marrow that produce red blood cells, white blood cells, and platelets) to increase production of neutrophils (a type of white blood cell) in the body.

Content on this page was last updated on 16 February, 2017, by Dr. Varun Gupta (MD Pharmacology)