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Zonit 25mg Capsule

Zonisamide (25mg)
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Zonit 25mg Capsule is an anti-epileptic medicine used to treat seizures in epilepsy. It can be used by itself to treat adults or along with other medicines to treat adults and children. It helps to prevent seizures affecting a part or whole of the brain.

Written By Dr. Swati Mishra, BDS,
Reviewed By Dr. Sachin Gupta, MD Pharmacology, MBBS,
Last updated on 29 Apr 2026 | 11:11 AM (IST)
₹22.8 MRP ₹24.979% off 
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Zonit 25mg Capsule
Zonit 25mg Capsule
strip of 10 capsules
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General Information

The content is shown in English
Zonit 25mg Capsule image
Zonit 25mg Capsule image

Product introduction

Zonit 25mg Capsule suppresses the abnormal electrical activity in the brain. You can take it with or without food but try to take it at the same time each day to get the most benefit. The dose will depend on your condition and how you respond to the medicine. Your doctor will advise the right dose for you.

You should continue taking it for as long as your doctor has told you to, even if you feel well. If you stop or miss doses your seizures could get worse. It may take several months to come off it safely. It is advised not to change the brand of medication without doctor consultation, and always keep a stock of medicine with you.

Very few people taking it have any serious problems but the most common side effects of this medicine include dizziness, loss of appetite, memory loss, drowsiness, and impaired concentration. You may also experience altered walking, impaired coordination, and unusual anger. Side effects are more common during the first few weeks and usually lessen as your body gets used to the medicine. Most do not need medical attention, but some of them can be serious. Let your doctor know if you have any symptoms as there may be ways of preventing or reducing them.

A small number of people being treated with this medicine have had thoughts of harming or killing themselves. Contact your doctor if your mood changes for the worse. Please do not take this medicine if you are allergic to sulfa medicines.

Before taking it, you should tell your doctor if you have kidney problems, depression or suicidal thoughts and if you are pregnant or planning to become pregnant. You should not breastfeed while taking this medicine. Alcohol may increase the risk of seizures and worsen the side effects such as drowsiness and dizziness. Avoid alcohol while taking this medicine. Drowsiness and dizziness may affect your ability to drive or operate machinery. Your kidney function may need to be tested often while taking this medicine.

Uses of Zonit Capsule

Benefits of Zonit Capsule

Epilepsy/Seizures
Zonit 25mg Capsule slows down electrical signals in the brain which cause seizures (fits). It can also help reduce symptoms such as confusion, uncontrollable jerking movements, loss of awareness, and fear or anxiety. The medicine can allow you to do some activities that you would otherwise be forbidden or scared to do (such as swimming and driving). It can take a few weeks for this medicine to work (because the dose has to be increased slowly) and during this time you may still have seizures. Do not stop using this medicine even if you feel well, until your doctor advises you to. Missing doses may trigger a seizure.

Side effects of Zonit Capsule

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Zonit
  • Dizziness
  • Loss of appetite
  • Memory impairment
  • Drowsiness
  • Impaired concentration
  • Altered walking
  • Impaired coordination
  • Anger

How to use Zonit Capsule

Take this medicine in the dose and duration as advised by your doctor. Zonit 25mg Capsule may be taken with or without food.

How Zonit Capsule works

Zonit 25mg Capsule is an antiepileptic medication. It prevents seizures in patients with epilepsy by suppressing the abnormal and excessive activity of the nerve cells in the brain.

All substitutes for Zonit 25mg Capsule

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

  • Take your medication regularly as directed by your doctor as missing doses can trigger seizures.
  • Do not change the brand of your medicine and make sure that you have sufficient amount of medicine present with you.
  • Some healthy tips to prevent seizures:
    • Take a healthy diet along with regular exercise.
    • Practice yoga every day.
    • Get enough sleep at nighttime.
    • Limit the use of screen time such as mobile/ laptop.
    • Take your medication on time.
  • Do not drive or do anything that requires mental focus until you know how this medicine affects you.
  • Drink plenty of water while taking Zonit 25mg Capsule to reduce the risk of kidney stones and heat stroke. Inform your doctor if you have sudden pain in your stomach, pain on urinating, or if you find blood in your urine.
  • It may cause loss of appetite and weight. Monitor your weight regularly.
  • Inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or suicidal thoughts or behavior.
  • Do not stop taking the medication suddenly without talking to your doctor as it may increase the seizure frequency.
  • Zonit 25mg Capsule is used along with other medicines to help control your seizures.
  • Do not drive or do anything that requires mental focus until you know how this medicine affects you.
  • Dress lightly during hot climates or when exercising and check carefully for signs of decreased sweating or heat stroke.
  • Drink plenty of water while taking Zonit 25mg Capsule to reduce the risk of kidney stones and heat stroke. Inform your doctor if you have sudden pain in your stomach, pain on urinating, or if you find blood in your urine.
  • It may cause loss of appetite and weight. Monitor your weight regularly.
  • Inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or suicidal thoughts or behavior.
  • Do not stop taking the medication suddenly without talking to your doctor as it may increase the seizure frequency.
  • Take your medication regularly as directed by your doctor as missing doses can trigger seizures.
  • Do not change the brand of your medicine and make sure that you have sufficient amount of medicine present with you.
  • Some healthy tips to prevent seizures:
    • Take a healthy diet along with regular exercise.
    • Practice yoga every day.
    • Get enough sleep at nighttime.
    • Limit the use of screen time such as mobile/ laptop.
    • Take your medication on time.

Safety advice

Alcohol

Alcohol

CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Zonit 25mg Capsule. Please consult your doctor.
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
Zonit 25mg Capsule is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Zonit 25mg Capsule may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.
Driving

Driving

UNSAFE
Zonit 25mg Capsule may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
As Zonit 25mg Capsule may affect your concentration, ability to react/respond, and may make you feel sleepy, particularly at the beginning of your treatment or after your dose is increased.
Kidney

Kidney

CAUTION
Zonit 25mg Capsule should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.
Liver

Liver

CAUTION
Zonit 25mg Capsule should be used with caution in patients with liver disease. Dose adjustment may be needed.
Use of Zonit 25mg Capsule is not recommended in patients with severe liver disease.

Interaction with drugs

Taking Zonit with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Moderate

Metformin (Oral Route)

If concurrent use is essential, watch out for symptoms such as weakness, nausea, vomiting, abdominal pain, irregular heartbeat, fatigue or loss of appetite and consult your doctor if you experience them. They may monitor your kidney function frequently.
Moderate

Orlistat (Oral Route)

Watch out for symptoms such as tremors. seizures or impaired coordination and consult your doctor if you experience them. Your doctor may consider separating the administration of Orlistat and Zonisamide. Orlistat may reduce efficacy of Zonisamide.
Moderate

Carbamazepine (Oral Route)

Your doctor may monitor the effects of Zonisamide along with your overall treatment and adjust the doses as per the observations. Carbamazepine may reduce blood levels of Zonisamide.
Moderate

Fosphenytoin (Injection Route)

Your doctor may monitor the effects of Zonisamide along with your overall treatment and adjust the doses as per the observations. Fosphenytoin may reduce blood levels of Zonisamide.
Moderate

Phenobarbitone (Oral Route)

Your doctor may monitor your treatment and adjust the doses as per the observations. Phenobarbitone may reduce blood levels of Zonisamide.

Frequently asked questions

Do not stop taking Zonit 25mg Capsule without talking to your doctor. Stopping Zonit 25mg Capsule suddenly may cause serious problems, including seizures that will not stop.
Severe muscle pain or weakness, with or without fever, could be due to Zonit 25mg Capsule. Consult your doctor immediately. The doctor may suggest some blood tests to check your levels of serum creatine phosphokinase and aldolase enzymes. Elevated levels of these enzymes may prompt the doctor to discontinue Zonit 25mg Capsule.
Zonit 25mg Capsule works well in children and is well tolerated by most of them. The common side effects in children include problems with thinking or behavior, followed by stomach upset. One dangerous side effect of Zonit 25mg Capsule in children is decreased sweating with fever. This affects children but not adults and is more common in summers.
Though uncommon, Zonit 25mg Capsule may increase the risk of suicidal thoughts or behavior. Sometimes, it can also be due to the disease itself. You should immediately consult your doctor who will consider discontinuing Zonit 25mg Capsule. We recommend that you take the help of your friend or relative to go to the hospital.
Yes, Zonit 25mg Capsule may cause weight loss. If you lose weight, consult a dietician for dietary supplement or try to increase your food portions. In case you lose a lot of weight, consider discontinuing Zonit 25mg Capsule after consulting your doctor. Weight loss may be more serious in children, so be cautious and keep monitoring the weight.
No, Zonit 25mg Capsule does not interfere with the working of birth control pills.
Yes, if you are at a risk of developing kidney stones, taking Zonit 25mg Capsule may increase that risk. Stones can lead to further kidney damage. The symptoms of kidney stones include severe sharp pain in lower abdomen or back pain. Increase your fluid intake which can reduce the risk of kidney stones. Consult your doctor if you get any such symptoms.

Fact Box

Chemical Class

Benzisoxazoles

Habit Forming

No

Therapeutic Class

NEURO CNS

Action Class

Carbonic Anhydrase Inhibitors (CAIs)- Brain

References

  1. Stahl SM, editor. Zonisamide. In: Stahl's Essential Pschopharmacology: Prescriber's Guide. 5th ed. New York, New York: Cambridge University Press; 2014. pp. 755-58.
  2. McNamara JO. Pharmacotherapy of the Epilepsies. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 602.
  3. Porters RJ, Meldrum BS. Antiseizure Drugs. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 412.
  4. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1520-21.
  5. Zonisamide [FDA Label]. St. Michael, Barbados: Concordia Pharmaceuticals Inc.2015 [Revised April 2016]. [Accessed 19 Mar. 2019] (online) Available from:
  6. Zonisamide [Package Leaflet]. Hatfield, UK: Eisai Manufacturing Ltd.; 2018. [Accessed 17 Jun. 2019] (online) Available from:
  7. Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Zonisamide. [Updated 2020 Jan 20]. [Accessed 20 Feb. 2020] (online) Available from:
  8. Central Drugs Standard Control Organisation (CDSCO). [Accessed 19 Mar. 2019] (online) Available from:
  9. Zonisamide [Product Information]. Ahmedabad, India: Zydus Lifesciences Ltd.; 2022. [Accessed 07 Aug. 2023]. (online) Available from:
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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Torrent Pharmaceuticals Ltd
Address: Off. Ashram Road, Ahmedabad - 380 009., Gujarat, India

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Country of origin: India
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