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Zonisamide is used in the treatment of epilepsy

How it works

Zonisamide control seizures or fits by suppressing the abnormal and excessive activity of the nerve cells in the brain.

Common side effects

Sleepiness, Decreased appetite, Nausea, Agitation, Headache, Dizziness

Available Medicine

  • ₹208
    Eisai Pharmaceuticals India Pvt Ltd
    1 variant(s)
  • ₹34 to ₹122
    Sun Pharmaceutical Industries Ltd
    3 variant(s)
  • ₹33 to ₹122
    Intas Pharmaceuticals Ltd
    3 variant(s)
  • ₹26
    Torrent Pharmaceuticals Ltd
    1 variant(s)
  • ₹100
    Zydus Cadila
    1 variant(s)
  • ₹57 to ₹93
    Abbott India Ltd
    2 variant(s)

Expert advice

  • If your child (<12 years old) has been prescribed with zonisamide, ask your doctor for necessary precautions, as they are at greater risk of reduced sweating, heat stroke, pneumonia and liver problems.
  • Dress lightly during hot climates or when exercising and check carefully for signs of decreased sweating or heat stroke.
  • Drink sufficient water while taking zonisamide to reduce the risk of kidney stones and heat strokes.
  • Do not stop using zonisamide suddenly, even if you feel fine as stopping suddenly may cause increased seizures. 
  • Seek immediate medical attention if you develop serious and sometimes fatal skin reactions (Stevens-Johnson syndrome, toxic epidermal necrolysis), as zonisamide (sulfa medicine) is known to cause such side effects.
  • Inform your doctor and seek medical advice if you develop any signs of suicidal thoughts or actions, depressed mood, anxious state, restlessness, irritable behavior or any unusual change in mood or behavior; high fever or long lasting fever.
  • Do not drive or operate machinery as zonisamide may cause dizziness, drowsiness, or vision changes.
  • Tell your doctor if you are or planning to become pregnant or are breastfeeding.

Frequently asked questions



Is zonisamide a controlled substance/ addictive/ Narcotic/ gluten free/ generic?
Yes, Zonisamide is a controlled drug. It is not an addictive or narcotic drug. It is gluten free and a generic drug


Is zonisamide used for weight loss or migraines?
Zonisamide is not used to treat weight loss or migraines


Can I take ibuprofen/prednisone with zonisamide?
Yes, Ibuprofen or prednisone can be taken with zonisamide

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Does zonisamide cause weight gain/ kidney stones/hair loss/ weight loss/ diarrhea/ depression/ constipation/feeling high?
Zonisamide commonly does not cause all the above mentioned side effects except depression. Please consult your doctor if you develop such side effects.

Content on this page was last updated on 25 March, 2017, by Dr. Varun Gupta (MD Pharmacology)