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Fosphenytoin
INFORMATION ABOUT FOSPHENYTOIN
Fosphenytoin Uses
Fosphenytoin is used in the treatment of epilepsy, epilepsy/seizures, mania, migraine, trigeminal neuralgia and seizures.
How Fosphenytoin works
Fosphenytoin is an antiepileptic medication. It controls seizures or fits by decreasing the abnormal and excessive activity of the nerve cells in the brain.
Common side effects of Fosphenytoin
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common
Vomiting, Sleepiness, Dizziness, Itching, Nystagmus (involuntary eye movement), Headache, Nausea, Dryness in mouth, Blurred vision, Paresthesia (tingling or pricking sensation), Vertigo, Tremors, Euphoria (feeling of intense excitement and happiness), Taste change, Ringing in ear, Abnormality of voluntary movements, Coordination disorder, Difficulty in speaking, Stupor, Visual impairment, Lazy eye, Deafness, Hypotension (low blood pressure), Ecchymosis (discoloration of the skin resulting from bleeding underneath), Injection site reactions (pain, swelling, redness), Weakness, Chills
CONTENT DETAILS
Written By
Dr. Swati Mishra
BDS
Reviewed By
Dr. Rajeev Sharma
MBA, MBBS
Last updated
03 Dec 2024 | 05:08 AM (UTC)
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Expert advice for Fosphenytoin
  • It is given as an injection either into a vein (intravenously) or into a muscle (intramuscularly).
  • Take your medication regularly as directed by your doctor as missing doses can trigger seizures.
  • Do not change the brand of your medicine and make sure that you have sufficient amount of medicine present with you.
  • Some healthy tips to prevent seizures:
    • Practice yoga every day.
    • Get enough sleep at nighttime.
    • Limit the use of screen time such as mobile/laptop.
    • Take your medication on time.
  • It may cause dizziness and sleepiness. Do not drive or do anything that requires mental focus until you know how it affects you.
  • It may increase blood sugar levels.Inform your doctor if you are taking any medicines to treat diabetes.
  • Inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or suicidal thoughts or behavior.
  • Fosphenytoin helps in the treatment and prevention of seizures.
  • Take it at the same time every day to maintain consistent levels in your body.
  • It may cause dizziness and sleepiness. Do not drive or do anything that requires mental focus until you know how it affects you.
  • Avoid consuming alcohol when taking Fosphenytoin, as it may cause excessive sleepiness or drowsiness.
  • Monitor your weight during treatment with this medicine as it can cause weight gain.
  • Inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or suicidal thoughts or behavior.
  • Do not take Fosphenytoin if you are pregnant or planning to conceive or breastfeeding.
  • Do not stop taking the medication suddenly without talking to your doctor as it may increase the seizure frequency.
  • Take your medication regularly as directed by your doctor as missing doses can trigger seizures.
  • Do not change the brand of your medicine and make sure that you have sufficient amount of medicine present with you.
  • Some healthy tips to prevent seizures:
    • Practice yoga every day.
    • Get enough sleep at nighttime.
    • Limit the use of screen time such as mobile/laptop.
    • Take your medication on time.
  • It may increase the risk of low sodium levels in the blood. Inform your doctor if you develop difficulty concentrating, memory problems, confusion, weakness, and unsteadiness.
  • Talk to your doctor if you notice sudden mood changes or develop suicidal thoughts.
Frequently asked questions for Fosphenytoin
Fosphenytoin does not have side effects which are commonly associated with the use of phenytoin such as injection site irritation and sudden changes in the heart rate (arrhythmia), hence Fosphenytoin is better than phenytoin.
Suddenly stopping Fosphenytoin may cause non-stop seizures (called status epilepticus), which can endanger life. Hence, do not stop taking the medicine without consulting your doctor. If required, your doctor may slowly reduce the dose before stopping it completely.
The most common side effects related to Fosphenytoin in children are jerky movements of the eyes (nystagmus) and overgrowth of the gums. In some children, Fosphenytoin causes problems with thinking or behavior, mood change, slow or clumsy movements, or a loss of energy. Other side effects from high doses include unsteadiness in the feet and hands, sleepiness, and vomiting. These may be avoidable if the dose is increased slowly. These side effects quickly disappear when the dose is reduced.
On an average, Fosphenytoin may stay in your system for 5-6 days. This duration varies from person to person. In some cases, it may stay for about 9-10 days.
Fosphenytoin does affect birth control. Fosphenytoin can decrease the effect of oral contraceptives (birth control pills) which can make the contraceptive (birth control) effect unreliable. Please talk to your doctor if you are asked to take the two medicines together as you may need to use extra protection for birth control.
Fosphenytoin can make you feel sleepy (sedation, somnolence, and drowsiness). Please consult your doctor if you feel very sleepy after taking Fosphenytoin, especially during the first few weeks of treatment or following a dose increase. Talk to your doctor as you may be advised not to drive or use machines until it is established that your ability to perform such activities is not affected.
No, Fosphenytoin has not been reported to cause weight gain. However, weight loss can occur with longer term use of a higher dose of Fosphenytoin. Please consult your doctor if you experience weight gain after taking Fosphenytoin.