Zonimid 100 Capsule

Reviewed By Dr. Sachin Gupta, MD Pharmacology, MBBS

Last updated on 09 Apr 2026 | 04:41 PM (IST)

Zonimid 100 Capsule is an anti-epileptic medicine used to treat seizures in epilepsy. It can be used by itself to treat adults or along with other medicines to treat adults and children. It helps to prevent seizures affecting a part or whole of the brain.

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General Information

Contains

Zonisamide (100mg)

Marketer

Intas Pharmaceuticals Ltd

Storage

Store below 25°C

The content is shown in English

Product introduction

Zonimid 100 Capsule suppresses the abnormal electrical activity in the brain. You can take it with or without food but try to take it at the same time each day to get the most benefit. The dose will depend on your condition and how you respond to the medicine. Your doctor will advise the right dose for you.

You should continue taking it for as long as your doctor has told you to, even if you feel well. If you stop or miss doses your seizures could get worse. It may take several months to come off it safely. It is advised not to change the brand of medication without doctor consultation, and always keep a stock of medicine with you.

Very few people taking it have any serious problems but the most common side effects of this medicine include dizziness, loss of appetite, memory loss, drowsiness, and impaired concentration. You may also experience altered walking, impaired coordination, and unusual anger. Side effects are more common during the first few weeks and usually lessen as your body gets used to the medicine. Most do not need medical attention, but some of them can be serious. Let your doctor know if you have any symptoms as there may be ways of preventing or reducing them.

A small number of people being treated with this medicine have had thoughts of harming or killing themselves. Contact your doctor if your mood changes for the worse. Please do not take this medicine if you are allergic to sulfa medicines.

Before taking it, you should tell your doctor if you have kidney problems, depression or suicidal thoughts and if you are pregnant or planning to become pregnant. You should not breastfeed while taking this medicine. Alcohol may increase the risk of seizures and worsen the side effects such as drowsiness and dizziness. Avoid alcohol while taking this medicine. Drowsiness and dizziness may affect your ability to drive or operate machinery. Your kidney function may need to be tested often while taking this medicine.

Uses of Zonimid Capsule

Benefits of Zonimid Capsule

Epilepsy/Seizures
Zonimid 100 Capsule slows down electrical signals in the brain which cause seizures (fits). It can also help reduce symptoms such as confusion, uncontrollable jerking movements, loss of awareness, and fear or anxiety. The medicine can allow you to do some activities that you would otherwise be forbidden or scared to do (such as swimming and driving). It can take a few weeks for this medicine to work (because the dose has to be increased slowly) and during this time you may still have seizures. Do not stop using this medicine even if you feel well, until your doctor advises you to. Missing doses may trigger a seizure.

Side effects of Zonimid Capsule

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Zonimid

Dizziness
Loss of appetite
Memory impairment
Drowsiness
Impaired concentration
Altered walking
Impaired coordination
Anger

How to use Zonimid Capsule

Take this medicine in the dose and duration as advised by your doctor. Zonimid 100 Capsule may be taken with or without food.

How Zonimid Capsule works

Zonimid 100 Capsule is an antiepileptic medication. It prevents seizures in patients with epilepsy by suppressing the abnormal and excessive activity of the nerve cells in the brain.

All substitutes for Zonimid 100 Capsule

For information purposes only. Consult a doctor before taking any medicine.

Zonisep 100 Capsule

by Sun Pharmaceutical Industries Ltd

₹21.3/capsule

1% cheaper

Quick tips

Take your medication regularly as directed by your doctor as missing doses can trigger seizures.
Do not change the brand of your medicine and make sure that you have sufficient amount of medicine present with you.
Some healthy tips to prevent seizures:
- Take a healthy diet along with regular exercise.
- Practice yoga every day.
- Get enough sleep at nighttime.
- Limit the use of screen time such as mobile/ laptop.
- Take your medication on time.
Do not drive or do anything that requires mental focus until you know how this medicine affects you.
Drink plenty of water while taking Zonimid 100 Capsule to reduce the risk of kidney stones and heat stroke. Inform your doctor if you have sudden pain in your stomach, pain on urinating, or if you find blood in your urine.
It may cause loss of appetite and weight. Monitor your weight regularly.
Inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or suicidal thoughts or behavior.
Do not stop taking the medication suddenly without talking to your doctor as it may increase the seizure frequency.
Zonimid 100 Capsule is used along with other medicines to help control your seizures.
Do not drive or do anything that requires mental focus until you know how this medicine affects you.
Dress lightly during hot climates or when exercising and check carefully for signs of decreased sweating or heat stroke.
Drink plenty of water while taking Zonimid 100 Capsule to reduce the risk of kidney stones and heat stroke. Inform your doctor if you have sudden pain in your stomach, pain on urinating, or if you find blood in your urine.
It may cause loss of appetite and weight. Monitor your weight regularly.
Inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or suicidal thoughts or behavior.
Do not stop taking the medication suddenly without talking to your doctor as it may increase the seizure frequency.
Take your medication regularly as directed by your doctor as missing doses can trigger seizures.
Do not change the brand of your medicine and make sure that you have sufficient amount of medicine present with you.
Some healthy tips to prevent seizures:
- Take a healthy diet along with regular exercise.
- Practice yoga every day.
- Get enough sleep at nighttime.
- Limit the use of screen time such as mobile/ laptop.
- Take your medication on time.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Zonimid 100 Capsule. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

Zonimid 100 Capsule is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.

Breast feeding

CONSULT YOUR DOCTOR

Zonimid 100 Capsule may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.

Driving

UNSAFE

Zonimid 100 Capsule may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
As Zonimid 100 Capsule may affect your concentration, ability to react/respond, and may make you feel sleepy, particularly at the beginning of your treatment or after your dose is increased.

Kidney

CAUTION

Zonimid 100 Capsule should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.

Liver

CAUTION

Zonimid 100 Capsule should be used with caution in patients with liver disease. Dose adjustment may be needed.
Use of Zonimid 100 Capsule is not recommended in patients with severe liver disease.

Interaction with drugs

Taking Zonimid with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Moderate

Metformin (Oral Route)

If concurrent use is essential, watch out for symptoms such as weakness, nausea, vomiting, abdominal pain, irregular heartbeat, fatigue or loss of appetite and consult your doctor if you experience them. They may monitor your kidney function frequently.

Moderate

Orlistat (Oral Route)

Watch out for symptoms such as tremors. seizures or impaired coordination and consult your doctor if you experience them. Your doctor may consider separating the administration of Orlistat and Zonisamide. Orlistat may reduce efficacy of Zonisamide.

Moderate

Carbamazepine (Oral Route)

Your doctor may monitor the effects of Zonisamide along with your overall treatment and adjust the doses as per the observations. Carbamazepine may reduce blood levels of Zonisamide.

Moderate

Fosphenytoin (Injection Route)

Your doctor may monitor the effects of Zonisamide along with your overall treatment and adjust the doses as per the observations. Fosphenytoin may reduce blood levels of Zonisamide.

Moderate

Phenobarbitone (Oral Route)

Your doctor may monitor your treatment and adjust the doses as per the observations. Phenobarbitone may reduce blood levels of Zonisamide.

Frequently asked questions

What happens if I stop taking Zonimid 100 Capsule?

Do not stop taking Zonimid 100 Capsule without talking to your doctor. Stopping Zonimid 100 Capsule suddenly may cause serious problems, including seizures that will not stop.

My friend, who was on Zonimid 100 Capsule, developed severe muscle pain with fever. What could this be due to?

Severe muscle pain or weakness, with or without fever, could be due to Zonimid 100 Capsule. Consult your doctor immediately. The doctor may suggest some blood tests to check your levels of serum creatine phosphokinase and aldolase enzymes. Elevated levels of these enzymes may prompt the doctor to discontinue Zonimid 100 Capsule.

What are the effects of Zonimid 100 Capsule in children?

Zonimid 100 Capsule works well in children and is well tolerated by most of them. The common side effects in children include problems with thinking or behavior, followed by stomach upset. One dangerous side effect of Zonimid 100 Capsule in children is decreased sweating with fever. This affects children but not adults and is more common in summers.

I have been taking Zonimid 100 Capsule for epilepsy since a month, but now I feel that my life has come to an end and sometimes I want to harm myself. Is it because of the medicine? What should I do?

Though uncommon, Zonimid 100 Capsule may increase the risk of suicidal thoughts or behavior. Sometimes, it can also be due to the disease itself. You should immediately consult your doctor who will consider discontinuing Zonimid 100 Capsule. We recommend that you take the help of your friend or relative to go to the hospital.

Does Zonimid 100 Capsule cause weight loss?

Yes, Zonimid 100 Capsule may cause weight loss. If you lose weight, consult a dietician for dietary supplement or try to increase your food portions. In case you lose a lot of weight, consider discontinuing Zonimid 100 Capsule after consulting your doctor. Weight loss may be more serious in children, so be cautious and keep monitoring the weight.

Does Zonimid 100 Capsule affect the working of birth control pills?

No, Zonimid 100 Capsule does not interfere with the working of birth control pills.

Does Zonimid 100 Capsule have any effect on kidneys?

Yes, if you are at a risk of developing kidney stones, taking Zonimid 100 Capsule may increase that risk. Stones can lead to further kidney damage. The symptoms of kidney stones include severe sharp pain in lower abdomen or back pain. Increase your fluid intake which can reduce the risk of kidney stones. Consult your doctor if you get any such symptoms.

Fact Box

Chemical Class

Benzisoxazoles

Habit Forming

Therapeutic Class

NEURO CNS

Action Class

Carbonic Anhydrase Inhibitors (CAIs)- Brain

References

Stahl SM, editor. Zonisamide. In: Stahl's Essential Pschopharmacology: Prescriber's Guide. 5th ed. New York, New York: Cambridge University Press; 2014. pp. 755-58.
McNamara JO. Pharmacotherapy of the Epilepsies. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 602.
Porters RJ, Meldrum BS. Antiseizure Drugs. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 412.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1520-21.
Zonisamide [FDA Label]. St. Michael, Barbados: Concordia Pharmaceuticals Inc.2015 [Revised April 2016]. [Accessed 19 Mar. 2019] (online) Available from:
Zonisamide [Package Leaflet]. Hatfield, UK: Eisai Manufacturing Ltd.; 2018. [Accessed 17 Jun. 2019] (online) Available from:
Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Zonisamide. [Updated 2020 Jan 20]. [Accessed 20 Feb. 2020] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 19 Mar. 2019] (online) Available from:
Zonisamide [Product Information]. Ahmedabad, India: Zydus Lifesciences Ltd.; 2022. [Accessed 07 Aug. 2023]. (online) Available from:

User feedback

Patients taking Zonimid 100 Capsule

Twice A Day

67%

Once A Day

28%

Thrice A Day

What are you using Zonimid Capsule for?

Epilepsy

100%

How much was the improvement?

Excellent

56%

Average

44%

What were the side-effects while using Zonimid 100 Capsule?

No Side Effect

67%

Memory impairment

33%

How do you take Zonimid Capsule?

Empty stomach

33%

With food

33%

With or without food

33%

Please rate Zonimid 100 Capsule on price

Expensive

89%

Average

11%

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Intas Pharmaceuticals Ltd
Address: Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India.

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Zonimid 100 Capsule. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

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Zonimid 100 Capsule

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General Information

Contains

Marketer

Storage

Product introduction

Uses of Zonimid Capsule

Benefits of Zonimid Capsule

Side effects of Zonimid Capsule

How to use Zonimid Capsule

How Zonimid Capsule works

All substitutes for Zonimid 100 Capsule

Zonisep 100 Capsule

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Metformin (Oral Route)

Orlistat (Oral Route)

Carbamazepine (Oral Route)

Fosphenytoin (Injection Route)

Phenobarbitone (Oral Route)

Frequently asked questions

What happens if I stop taking Zonimid 100 Capsule?

My friend, who was on Zonimid 100 Capsule, developed severe muscle pain with fever. What could this be due to?

What are the effects of Zonimid 100 Capsule in children?

I have been taking Zonimid 100 Capsule for epilepsy since a month, but now I feel that my life has come to an end and sometimes I want to harm myself. Is it because of the medicine? What should I do?

Does Zonimid 100 Capsule cause weight loss?

Does Zonimid 100 Capsule affect the working of birth control pills?

Does Zonimid 100 Capsule have any effect on kidneys?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

References

User feedback

Patients taking Zonimid 100 Capsule

What are you using Zonimid Capsule for?

How much was the improvement?

What were the side-effects while using Zonimid 100 Capsule?

How do you take Zonimid Capsule?

Please rate Zonimid 100 Capsule on price

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

In case of any issues, contact us

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