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Zin 500mg Tablet


Overview

Introduction

Zin 500mg Tablet is an antibiotic that belongs to a class of medicines known as anti tuberculosis drugs. It is used in the treatment of tuberculosis, an infectious disease that mainly affects the lungs and in some cases other parts of the body.

Zin 500mg Tablet is given in combination with at least one other tuberculosis medicine. It acts by killing the causative bacteria. It should be used in the dose and duration as advised by your doctor. This medicine may be taken with or without food, preferably at a fixed time every day to avoid a missed dose. Do not skip any doses and finish the full course of treatment even if you feel better. Stopping it early can result in treatment failure and increase the side effects too. Please let your doctor know about any changes in your weight as the dose of this medicine depends on the overall body weight of a person. Any changes in weight might need dose modification.

If you miss a dose, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose, as it may increase the side effects.

Inform your doctor if you notice signs of jaundice i.e. yellowing of eyes or skin, dark urine, stomach pain or joint pain. You may also develop hepatitis (viral infection of the liver), increased liver enzymes and joint pain as side effects of this medicine. Please consult your doctor, as these side effects require medical attention and might need dose modification.

Your doctor may monitor your liver function while on treatment with this medicine. Avoid drinking alcohol as this may have additional adverse effects on the liver. Pregnant or breastfeeding women should consult their doctor before using this medicine.

Uses of Zin Tablet

Side effects of Zin Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Zin

  • Jaundice
  • Hepatitis (viral infection of liver)
  • Increased liver enzymes
  • Joint pain

How to cope with side effects?

The occurrence of side effects varies from person to person. The following are a few ways of dealing with some of the common side effects. However, consult your doctor if these persist.

  • Coping with Hepatitis (viral infection of liver)
    There are several types of hepatitis. Find out which one you have. There is a vaccination for Hepatitis B. Ask your doctor about this. If you are diagnosed with hepatitis, get plenty of rest, take over-the-counter painkillers if you are in pain, and keep your home cool and well-ventilated. Eat a healthy diet and ask about medicines to stop you from feeling sick if this is a problem. You should avoid drinking alcohol, as it can worsen your condition.
  • Coping with Increased liver enzymes
    There may be no symptoms, so your doctor should carry out a blood test and give you advice. Some lifestyle changes can bring down levels of liver enzymes. In general, you will need to stop drinking alcohol or limit the amount you drink, lose weight and keep active. Drink plenty of fluids to avoid dehydration. Eat a healthy diet. Some particular foods like nuts, fatty fish, coffee, tea, olive oil, sprouts and bananas may be beneficial. Try to control stress as this can make your symptoms worse.
  • Coping with Joint pain
    Try to keep your joints moving. Get some gentle exercise like walking or cycling. Using hot and cold treatments on the joints can help reduce pain temporarily. Concentrate on your breathing when you are in pain. Try to get enough sleep. Practice some relaxation techniques or mediation. Avoid smoking as it can worsen your condition. Losing weight can make a big difference to the amount of pain. Ask your doctor to recommend some suitable painkillers if the pain bothers you or does not go away.

How to use Zin Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Zin 500mg Tablet may be taken with or without food, but it is better to take it at a fixed time.

How Zin Tablet works

Zin 500mg Tablet is an antitubercular medicine. In the body, it gets converted to pyrazinoic acid. This pyrazinoic acid inhibits fatty acid synthase I (bacterial enzyme), which is essential for bacterial growth. Thus, it works as a bacteriocidal to prohibit their growth and treats tuberculosis.

Safety Advice

Alcohol
CAUTION
Caution is advised when consuming alcohol with Zin 500mg Tablet. Please consult your doctor.
Pregnancy
CONSULT YOUR DOCTOR
Zin 500mg Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Breastfeeding
SAFE IF PRESCRIBED
Zin 500mg Tablet is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Driving
CONSULT YOUR DOCTOR
It is not known whether Zin 500mg Tablet alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.
Kidney
CAUTION
Zin 500mg Tablet should be used with caution in patients with severe kidney disease. Dose adjustment of Zin 500mg Tablet may be needed. Please consult your doctor.
Kidney function tests are advised before you start taking this medicine.
Liver
CAUTION
Zin 500mg Tablet should be used with caution in patients with liver disease. Dose adjustment of Zin 500mg Tablet may be needed. Please consult your doctor.
Regular monitoring of liver function tests is advised before and after the start of the treatment.

What if you forget to take Zin Tablet?

If you miss a dose of Zin 500mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Alternate Brands

For informational purposes only. Consult a doctor before taking any medicines.
Zin 500mg Tablet
₹4.1/Tablet
₹1.8/Tablet
save 56%
Pyranij 500mg Tablet
Sunij Pharma Pvt Ltd
₹3.96/Tablet
save 3%
Macrozide 500 Tablet
Macleods Pharmaceuticals Pvt Ltd
₹4.35/Tablet
6% costlier
₹4.42/Tablet
8% costlier
P Zide 500 Tablet
Cadila Pharmaceuticals Ltd
₹4.43/Tablet
8% costlier

Quick Tips

  • Zin 500mg Tablet along with other medications effectively treats tuberculosis.
  • Do not to forget a dose, as this increases the risk of the bacteria becoming resistant to the medicine, and also increases the risk of getting side effects.
  • Your doctor may check your liver function before starting treatment and regularly thereafter. Inform your doctor if you notice yellowing of eyes or skin, dark urine, or stomach pain.
  • Avoid drinking alcohol while taking Zin 500mg Tablet as this may increase the risk of side effects on the liver.
  • Use a reliable contraceptive method (such as condoms or a diaphragm) to prevent pregnancy while you are taking Zin 500mg Tablet as it may make hormonal contraceptives such as the pill less effective.

Fact Box

Chemical Class
Nicotinic acid derivatives
Habit Forming
No

Interaction with Drugs

Taking Zin with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Brand(s): Urinol, Zeric, Seloric
LIFE-THREATENING

Patient Concerns

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Erectile dysfunction taking l r zin forte from last 2 months but not effective properly
Dr. Deepak Kumar Soni
Ayurveda
Erectile dysfunction is the condition in which a man is unable to maintain an erection of the penis that is sufficient for sexual intercourse. A person may be able to get an erection while masturbating but fails to get an erection when he is with the sexual partner. There are many reasons for this condition. It includes narrowing of the blood vessels to the penis, changes in hormones, anxiety, depression, relationship problem or any injury. Tips for controlling ED: Dried dates offer good strength to the body and have the ability to increase sexual drive in humans. Mix a handful of dried date, pistachio nuts, almonds and quince seeds in equal proportions and then pound them into fine powder. Mix this powder in a glass of milk and consume it daily to see effective results.
My daughter is given tb medicine even though she is not infected taking these medicine will cause tb???
Dr. Rahul Yadav
Paediatrics
Hello, TB medicines are given only when there is indication of tuberculosis. They are for treating tuberculosis.
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FAQs

Q. What is Zin and what is it used for?

Zin is an antibiotic. It is used in combination with other antibiotics in the treatment of tuberculosis

Q. Is Zin bactericidal?

Zin is both a bacteriostatic and a bactericidal antibiotic. It stops the growth of bacteria (bacteriostatic) in certain cases and kills (bactericidal) the tuberculosis causing bacteria in other cases

Q. How does Zin work/treat tuberculosis?

Zin kills or stops growth of bacteria that causes tuberculosis (Mycobacterium tuberculosis). The exact mechanism of action for Zin is not known

Q. How does Zin cause hyperuricemia and gout?

Following oral intake of Zin, it gets converted in the body to pyrazinoic acid (active chemical form of Zin). Pyrazinoic acid blocks the excretion of urates (salt form of uric acid) by the kidneys. This causes an increase in blood levels of uric acid (hyperuricemia). Excess uric acid accumulation between joints causes pain, swelling, redness and stiffness in joints (gout).

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Disclaimer:

1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover all possible side effects, drug interactions or warnings or alerts. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

  1. Gumbo T. Chemotherapy of Tuberculosis, Mycobacterium Avium Complex Disease, and Leprosy. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1554-555.
  2. Chambers HF, Deck DH. Antimycobacterial Drugs. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 827.
  3. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1171-72.
  4. Drugs.com. Pyrazinamide. [Accessed 31 Mar. 2019] (online) Available from:External Link
  5. Chaves RG, Lamounier JA. Breastfeeding and maternal medications. J Pediatr (Rio J). 2004;80(5 Suppl):S189-S198 [Accessed 29 Mar. 2019] (online) Available from:External Link
  6. Central Drugs Standard Control Organisation (CDSCO). [Accessed 31 Mar. 2019] (online) Available from:External Link

Manufacturer/Marketer Address

B-117, Okhla Industrial Area, Phase I, New Delhi 110020
Country of Origin: India
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