Zemakool Tablet

Reviewed By Dr. Rajeev Sharma, MBA, MBBS

Last updated on 14 Apr 2026 | 04:21 PM (IST)

Zemakool Tablet is an anti-inflammatory medicine used to treat a type of bowel disease known as ulcerative colitis. It helps to reduce symptoms such as diarrhea, bleeding and stomach pain by reducing inflammation in the bowel.

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₹58.9 MRP ₹65.1810% off

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Mesalacure 400mg Tablet

₹67.8~~₹75~~

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Zemakool Tablet

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Same composition

Mesalacure 400mg Tablet

strip of 10 tablets

Mesalazine (400mg)

by Emcure Pharmaceuticals Ltd

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₹67.8

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General Information

Storage

Store below 30°C

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Product introduction

Zemakool Tablet may also be used to treat another type of bowel disease known as Crohn’s ileocolitis. It should be taken with food. The dose will depend on what you are being treated for but take it exactly as your doctor prescribes. You should keep taking this medicine for as long as your doctor recommends. If you stop treatment too early your symptoms may come back and your condition may worsen.

The most common side effects of this medicine include nausea, diarrhea, stomach pain, headache, itching, flatulence, and vomiting. If these symptoms bother you, do not go away, or get worse, let your doctor know. There may be ways of reducing or preventing them. Some people may get a severe allergic reaction that needs urgent medical attention. Contact your doctor immediately if you notice symptoms like swelling of the face, tongue, throat, or lips, unusual bleeding, bruising, rash, fever, sore throat, or excessive tiredness.

Before taking it, tell your doctor if you have any kidney or liver problems or a blockage in your stomach. Your age may also be a factor in deciding whether this medicine is suitable. Pregnant or breastfeeding women should also consult their doctor before taking this medicine. Let your doctor know about all other medications you are taking as some may affect, or be affected by this medicine.

Uses of Zemakool Tablet

Benefits of Zemakool Tablet

Ulcerative colitis
Ulcerative colitis is a form of inflammatory bowel disease (IBD) that causes inflammation and ulcers in the colon and rectum. Zemakool Tablet helps reduce the inflammation in the intestinal lining by targeting the disease locally. Reduction in inflammation promotes mucosal healing and causes symptoms like abdominal pain, diarrhea, and rectal bleeding to subside.

Crohn’s disease
Crohn’s disease is a type of inflammatory bowel disease that can affect any part of the digestive tract, causing symptoms like abdominal pain, diarrhea, and fatigue. Zemakool Tablet is used in mild to moderate cases to reduce inflammation and manage flare-ups. It can help prevent disease progression, reduce the need for steroids, and support intestinal health over time.

Side effects of Zemakool Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Zemakool

Flatulence
Headache
Vomiting
Diarrhea
Nausea
Abdominal pain
Rash
Stomach pain/epigastric pain

How to use Zemakool Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Zemakool Tablet may be taken with or without food.

How Zemakool Tablet works

Zemakool Tablet is an aminosalicylate. It works by suppressing the production of chemical messengers (prostaglandins) that cause inflammation (swelling) in the intestines. This reduces ulceration, bleeding and stomach pain, and prevents future flare-ups of the disease.

All substitutes for Zemakool Tablet

For information purposes only. Consult a doctor before taking any medicine.

Cosala 400mg Tablet

by Tas Med India Pvt Ltd

₹6.72/tablet

14% costlier

Mesalacure 400mg Tablet

by Emcure Pharmaceuticals Ltd

₹6.78/tablet

15% costlier

Quick tips

You have been prescribed Zemakool Tablet for treating and lowering the symptoms of mild inflammatory bowel disease such as ulcerative colitis.
Your doctor may monitor your kidney and liver functions before you start treatment with this medicine and regularly thereafter. Inform your doctor if you have severely decreased kidney or liver function.
Do not take Zemakool Tablet if you are allergic to aspirin or if you have blood disorders.
Do not stop taking the medication suddenly without talking to your doctor.
You have been prescribed Zemakool Tablet for treating and lowering the symptoms of mild inflammatory bowel disease such as ulcerative colitis.
Take it with food. Do not break, chew, or crush the tablets or granules. Swallow them whole with plenty of water.
Do not take antacids with Zemakool Tablet as it can make your inflammation worse.
Your doctor may monitor your kidney and liver functions before you start treatment with this medicine and regularly thereafter. Inform your doctor if you have severely decreased kidney or liver function.
Do not take Zemakool Tablet if you are allergic to aspirin or if you have blood disorders.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Zemakool Tablet. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

Zemakool Tablet is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.

Breast feeding

CAUTION

Zemakool Tablet should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from the body.
If you are taking Zemakool Tablet, monitor the baby for diarrhea.

Driving

SAFE

Zemakool Tablet does not usually affect your ability to drive.

Kidney

UNSAFE

Zemakool Tablet is unsafe to use in patients with kidney disease and should be avoided.
Use of Zemakool Tablet is not recommended in patients with severe kidney disease.

Liver

CONSULT YOUR DOCTOR

There is limited data available on the use of Zemakool Tablet in patients with liver disease.

Interaction with drugs

Taking Zemakool with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Moderate

Clozapine (Oral Route)

Your doctor may monitor your blood cell count and adjust the doses as per the observations.

Moderate

Azathioprine (Oral Route)

If concurrent use can not be avoided, your doctor may monitor your blood cell counts.

Moderate

Deferiprone (Oral Route)

If concurrent use can not be avoided, your doctor may monitor your blood cell counts.

Moderate

Mercaptopurine (Oral Route)

If concurrent use cannot be avoided, your doctor may monitor your blood cell counts.

Mild

Chlorpromazine (Oral Route)

Talk to your doctor if you notice any unusual symptoms.

Frequently asked questions

My symptoms have improved can I stop taking Zemakool Tablet?

Continue to take Zemakool Tablet as advised by the doctor, even if you feel better at the beginning of your treatment. Do not stop taking Zemakool Tablet without consulting your doctor.

Can I drink alcohol while taking Zemakool Tablet?

You should avoid alcohol if you have ulcerative colitis, as alcohol will irritate your stomach and intestine which will worsen your condition. Although alcohol does not interfere with the working of Zemakool Tablet, you should consult your doctor before taking alcohol.

Does Zemakool Tablet cause joint pain?

Yes, Zemakool Tablet may cause joint pain. If the pain continues and bothers you inform your doctor.

When is the best time to take Zemakool Tablet?

Take Zemakool Tablet exactly as directed by your doctor.

Fact Box

Chemical Class

Aminobenzoic acids

Habit Forming

Therapeutic Class

GASTRO INTESTINAL

Action Class

5-Aminosalicylic Acid (5-ASA)

Related lab tests

Anti Neutrophilic Cytoplasmic Antibody - P

Anti Saccharomyces Cerevisiae (ASCA), IgA

Anti Saccharomyces Cerevisiae (ASCA), IgG

C- Reactive Protein Quantitative

Erythrocyte Sedimentation Rate

References

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Alembic Pharmaceuticals Ltd
Address: Alembic Road, Vadodara - 390 003, Gujarat,INDIA

Vendor Details

Country of origin: India

Lab tests offered by us

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Zemakool Tablet

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General Information

Contains

Salt Synonyms

Marketer

Storage

Product introduction

Uses of Zemakool Tablet

Benefits of Zemakool Tablet

Side effects of Zemakool Tablet

How to use Zemakool Tablet

How Zemakool Tablet works

All substitutes for Zemakool Tablet

Cosala 400mg Tablet

Mesalacure 400mg Tablet

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Clozapine (Oral Route)

Azathioprine (Oral Route)

Deferiprone (Oral Route)

Mercaptopurine (Oral Route)

Chlorpromazine (Oral Route)

Frequently asked questions

My symptoms have improved can I stop taking Zemakool Tablet?

Can I drink alcohol while taking Zemakool Tablet?

Does Zemakool Tablet cause joint pain?

When is the best time to take Zemakool Tablet?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

Related lab tests

Anti Neutrophilic Cytoplasmic Antibody - P

Anti Saccharomyces Cerevisiae (ASCA), IgA

Anti Saccharomyces Cerevisiae (ASCA), IgG

C- Reactive Protein Quantitative

Erythrocyte Sedimentation Rate

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

Related/Popular tests