Tryplena 10mg Tablet

Reviewed By Dr. Rajeev Sharma, MBA, MBBS

Last updated on 10 Feb 2026 | 04:22 PM (IST)

Tryplena 10mg Tablet is a medicine used to treat depression by helping improve mood and reduce anxiety. It works by restoring the natural balance of certain brain chemicals that affect emotions. This helps relieve sadness, improves mental well-being, and makes daily life easier to manage.

Genuine

Authenticity Assured

Prescription

required

NPPA Regulated

Show Details

₹22.6 MRP ₹24.9810% off

Tryplena 10mg Tablet is currently sold out

Same composition alternative:

Tryptoford 10 Tablet

₹19.9~~₹25.4~~

12% cheaper alternative available

Sold out

Tryplena 10mg Tablet

strip of 10 tablets

₹22.6

~~₹24.98~~

Same composition

Tryptoford 10 Tablet

strip of 10 tablets

Amitriptyline (10mg)

by Leeford Healthcare Ltd

Get by 2pm, Tomorrow

₹19.9

₹1.69 per tablet

₹16.9

order for

₹1200

Save more with additional offers

10% cashback up to 200 on Min Transaction of Rs.1000, for first time users of Airtel Payments Bank.

Get cashback up to ₹500

Get upto Rs.500 Cashback on minimum transaction of Rs.999/- with Mobikwik Wallet.

Assured cashback up to ₹300*

Save more with additional offers

10% cashback up to 200 on Min Transaction of Rs.1000, for first time users of Airtel Payments Bank.

Get cashback up to ₹500

Get upto Rs.500 Cashback on minimum transaction of Rs.999/- with Mobikwik Wallet.

Assured cashback up to ₹300*

Get upto Rs.150 Cashback

General Information

Contains

Amitriptyline (10mg)

Marketer

Unistar Biotech Ltd

Storage

Store below 30°C

The content is shown in English

Product introduction

Tryplena 10mg Tablet is normally taken before bedtime because it can make you sleepy. It can be taken with or without food. The dose and how often you need to take it will be decided by your doctor so that you get the right amount to control your symptoms.

How long you need to use it will depend on what you are taking it for, but it is important to continue taking this medication even if you feel well. Do not stop taking the medicine suddenly without talking to your doctor. Stopping the medicine suddenly can worsen your condition or cause other symptoms. Your dose may be modified or gradually decreased before stopping the medication.

The most common side effects of this medicine include constipation, dry mouth, sleepiness, dizziness, and headache. It may also make you aggressive or confused, and can cause weight gain in some people.

This medicine is not addictive, but you can experience additional side effects (withdrawal symptoms) if you stop taking it suddenly. Your doctor may be able to suggest ways of preventing or reducing side effects if they bother you or do not go away. Serious side effects associated with this medicine are rare.

Uses of Tryplena Tablet

Treatment of Depression

Benefits of Tryplena Tablet

Treatment of Depression
Tryplena 10mg Tablet helps relieve symptoms of depression by increasing the levels of certain mood-regulating chemicals, such as serotonin and norepinephrine, in the brain. It improves mood, reduces feelings of sadness or hopelessness, and improves sleep quality. When use consistently as prescribed by the doctor, it can significantly improve a patient’s daily functioning and overall quality of life.

Side effects of Tryplena Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Tryplena

Constipation
Dryness in mouth
Sleepiness
Dizziness
Headache
Fatigue
Confusion

How to use Tryplena Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Tryplena 10mg Tablet may be taken with or without food.

How Tryplena Tablet works

Tryplena 10mg Tablet contains amitriptyline, an antidepressant (tricyclic antidepressant) that helps overcome depression. It works by increasing certain natural brain chemicals (serotonin and noradrenaline) that improve mood and reduce anxiety. This helps relieve depression and stabilize emotions.

All substitutes for Tryplena 10mg Tablet

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

Tryplena 10mg Tablet may cause sleepiness. Take it at bedtime and do not drive or do anything requiring concentration until you know how it affects you.
Avoid consuming alcohol when taking Tryplena 10mg Tablet, as it may cause excessive sleepiness.
Monitor your weight during the treatment, as this medicine can cause weight gain and increased appetite.
It may cause a sudden drop in your blood pressure. Rise slowly if you have been sitting or lying down.
Talk to your doctor if you notice sudden mood changes or develop suicidal thoughts.
Pay close attention to any changes, especially sudden changes, in mood, behaviors, thoughts, or feelings. This is very important when an antidepressant medicine is started or when the dose is changed.

Safety advice

Alcohol

UNSAFE

Do not drink alcohol while you are taking this medicine. Tryplena 10mg Tablet may cause excessive drowsiness when taken with alcohol.

Pregnancy

CONSULT YOUR DOCTOR

The safety of Tryplena 10mg Tablet during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.

Breast feeding

CONSULT YOUR DOCTOR

Tryplena 10mg Tablet may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.

Driving

UNSAFE

Tryplena 10mg Tablet may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Tryplena 10mg Tablet may impair your alertness which may affect your ability to drive.

Kidney

CONSULT YOUR DOCTOR

There is limited data available on the use of Tryplena 10mg Tablet in patients with kidney disease. Please consult your doctor.

Liver

CAUTION

Tryplena 10mg Tablet should be used with caution in patients with liver disease. Dose adjustment may be needed.
Use of Tryplena 10mg Tablet is not recommended in patients with severe liver disease.

Interaction with drugs

Taking Tryplena with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Life-threatening

Moclobemide (Oral Route)

Do not consume Moclobemide with Amitriptyline. If Moclobemide is essential, ensure a gap of at least 1 day after discontinuing Amitriptyline. Please consult your doctor.

Life-threatening

Domperidone (Oral Route)

Do not consume Domperidone with Amitriptyline.

Life-threatening

Tranylcypromine (Oral Route)

Do not consume Tranylcypromine with Amitriptyline. If Tranylcypromine is essential, ensure a gap of at least 2 weeks after discontinuing Amitriptyline. Please consult your doctor.

Severe

Tramadol (Injection Route)

Careful consideration is advised if you have epilepsy. Watch out for symptoms of serotonin syndrome, such as sedation, respiratory impairment, tremors, fever, diarrhea, or agitation, and consult your doctor if you experience them. Your doctor may alter or discontinue the medicines accordingly.

Severe

Thioridazine (Oral Route)

If concurrent use is essential, watch out for symptoms such as sleepiness, dry mouth, impaired voluntary movements, weight gain, constipation, muscle stiffness or tremors and consult your doctor if you experience them. Factors such as old age, chronic heart issues, or low potassium levels may more frequently cause disturbance in heart rhythm, and your doctor may consider ECG monitoring in their presence.

Frequently asked questions

What other lifestyle changes should I make to get maximum benefit of Tryplena 10mg Tablet?

Antidepressants, including Tryplena 10mg Tablet, are just one of several approaches to treat depression. Certain lifestyle changes can help you get the maximum benefit from Tryplena 10mg Tablet and help you recover fast. Keeping active and eating a healthy diet can make a significant difference in how quickly you recover from depression. Think positively and try to discuss your thoughts with others to reduce stress. Practice yoga or take up a hobby. Ensure that you have a sound sleep to calm your mind. Stay away from smoking or alcohol consumption, as these will only worsen your depression. Take your medicines as prescribed, even if you start feeling better.

Is there anything I need to be careful about while on therapy with Tryplena 10mg Tablet?

Tryplena 10mg Tablet may cause drowsiness and dizziness, especially at the beginning of the treatment. So, avoid driving or using machinery until you know how the medicine affects you. Also, it is not advisable to drink alcohol during treatment with this medicine, as it might increase sleepiness.

Can the use of Tryplena 10mg Tablet affect my sex life?

Yes, Tryplena 10mg Tablet can affect sex life in both men and women. It may cause decreased sexual desire, or you may experience discomfort during intercourse. Men may experience an inability to develop or maintain an erection during sexual activity and may be unable to have an orgasm. If you notice these symptoms, do not stop taking the medicine and consult your doctor.

I have been taking Tryplena 10mg Tablet for depression for a week, and recently I have been wanting to harm myself. What should I do? Is it because of the medicine?

You should immediately consult your doctor or go to the hospital. Your suicidal tendencies may have increased because of your disease or the medicine. Generally, Tryplena 10mg Tablet takes about 2 weeks to show its effect, but it may take longer. Therefore, when you start taking Tryplena 10mg Tablet, you may have thoughts about killing or harming yourself. This is more common in people who previously had suicidal tendencies or are young adults (less than 25 years old). However, the effect of medicine is different for every individual.

Does Tryplena 10mg Tablet cause any effect on pregnancy or the newborn?

Do not take Tryplena 10mg Tablet during pregnancy unless recommended by the doctor. If you take this medicine during the last trimester of pregnancy, the newborn may develop symptoms such as irritability, rigidity, irregular body movements, irregular breathing, poor feeding, loud crying, difficulty in urinating, and constipation.

How will Tryplena 10mg Tablet make me feel?

Antidepressants like Tryplena 10mg Tablet help gradually lift your mood. You may notice that you sleep better and are less anxious. You may worry less about little things that used to bother you. Tryplena 10mg Tablet will not make you feel excessively or unusually happy. It will help you feel like yourself again.

Fact Box

Chemical Class

Dibenzocycloheptenes

Habit Forming

Therapeutic Class

NEURO CNS

Action Class

Tricyclic Antidepressants (TCAs)

References

Stahl SM, editor. Amitriptyline. In: Stahl's Essential Pschopharmacology: Prescriber's Guide. 5th ed. New York, New York: Cambridge University Press; 2014. pp. 25-30.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 58-59.
Amitriptyline. Princeton: Sandoz Inc; 2014. [Accessed on 19 Mar. 2019] (online) Available from:
Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Amitriptyline. [Updated 2018 Oct 31]. [Accessed 19 Feb. 2020] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 19 Mar. 2019] (online) Available from:
Amitriptyline Hydrochloride [Drug Label]. Ahmedabad, Gujarat: Intas Pharmaceuticals Limited; 2016. [Accessed 25 Jul. 2024] (online) Available from:
Amitriptylin [Patient Information]. Versus Arthritis;. [Accessed 17 Mar. 2025] (online) Available from:
Amitriptyline Hydrochloride [Drug Label]. Ahmedabad, Gujarat: Intas Pharmaceuticals Limited; 2025. [Accessed 17 Mar. 2025] (online) Available from:

Want to know more

We provide you with authentic, trustworthy and relevant information

Have issue with the content

Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Unistar Biotech Ltd
Address: 5/6, Calico Nagar, Narol Ahmedabad Gujarat (India) - 382405

Vendor Details

Country of origin: India

Lab tests offered by us

Why we need a prescription?

Provide right medicines

Prescriptions are complex documents. We proof read and recheck at various steps to provide you the right medication in the correct form and dose

In accordance with the law

Most medicines cannot be sold without a valid prescription, as per the Drugs and Cosmetics Act, 1940 and Rules, 1945

Tryplena 10mg Tablet

Save more with additional offers

Save more with additional offers

General Information

Contains

Marketer

Storage

Product introduction

Uses of Tryplena Tablet

Benefits of Tryplena Tablet

Side effects of Tryplena Tablet

How to use Tryplena Tablet

How Tryplena Tablet works

All substitutes for Tryplena 10mg Tablet

Tryptinol 10mg Tablet

Tryptoford 10 Tablet

Tryptomer 10mg Tablet

ELIwel 10mg Tablet

amiTONE 10mg Tablet

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Moclobemide (Oral Route)

Domperidone (Oral Route)

Tranylcypromine (Oral Route)

Tramadol (Injection Route)

Thioridazine (Oral Route)

Frequently asked questions

What other lifestyle changes should I make to get maximum benefit of Tryplena 10mg Tablet?

Is there anything I need to be careful about while on therapy with Tryplena 10mg Tablet?

Can the use of Tryplena 10mg Tablet affect my sex life?

I have been taking Tryplena 10mg Tablet for depression for a week, and recently I have been wanting to harm myself. What should I do? Is it because of the medicine?

Does Tryplena 10mg Tablet cause any effect on pregnancy or the newborn?

How will Tryplena 10mg Tablet make me feel?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

Related/Popular tests