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Trima 300mg Tablet

Written By Dr. Anuj Saini, MMST, MBBS
Reviewed By Dr. Mekhala Chandra, MD, MBBS
Last updated on 07 Apr 2026 | 02:54 PM (IST)
Trima 300mg Tablet helps treat depression. It reduces and gradually eliminates the symptoms of depression such as deep sadness, feelings of worthlessness, loss of interest in activities, sleep disturbances, tiredness, feelings of anxiety, and weight changes.
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General Information

Contains

Moclobemide (300mg)

Marketer

Intas Pharmaceuticals Ltd

Storage

Store below 30°C
The content is shown in English
Trima 300mg Tablet image
Trima 300mg Tablet image

Product introduction

Trima 300mg Tablet should be taken with food. However, it is advised to take it at a fixed time each day to maintain a consistent level of medicine in the blood. If you have missed any doses, take it as soon as you remember and finish the full course of treatment even if you feel better. Do not stop taking it suddenly without talking to your doctor as it may worsen your symptoms.

Some common side effects of this medicine include nausea, vomiting, headache, fatigue, insomnia (difficulty sleeping), and dry mouth. Other side effects that may also be observed are constipation, restlessness, diarrhea, and agitation. However, these are temporary and usually resolve on their own in some time. Please consult your doctor if these do not subside or worry you. It even causes dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you.

Before taking this medicine, please tell your doctor if you suffer from any liver problems or diabetes. If you have been taking this medicine for a long time, regular monitoring of blood and liver functions may be required. It is important to inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or suicidal thoughts. Pregnant and breastfeeding mothers should consult their doctor before taking this medicine.

Uses of Trima Tablet

Benefits of Trima Tablet

Depression
Trima 300mg Tablet is used to relieve symptoms of depression by improving mood, energy levels, and interest in daily activities. It helps restore the balance of certain natural chemicals in the brain, making it easier to cope with emotional stress and feel more positive and motivated.

Side effects of Trima Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Trima
  • Nausea
  • Vomiting
  • Headache
  • Insomnia (difficulty in sleeping)
  • Dizziness
  • Dryness in mouth
  • Constipation
  • Restlessness
  • Diarrhea
  • Agitation

How to use Trima Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Trima 300mg Tablet should be taken with or after food.
Avoid Trima 300mg Tablet with tyramine-rich food such as cheese, smoked fish, meats and some types of beer.

How Trima Tablet works

Trima 300mg Tablet increases the levels of chemical messengers in the brain that helps in regulating the mood and treat depression.

Quick tips

  • Trima 300mg Tablet should be taken with food, preferably at the same time every day.
  • Do not drive or do anything requiring concentration until you know how Trima 300mg Tablet affects you.
  • As a precaution, foods high in tyramine (e.g., aged cheeses, air-dried meats, soy sauce, tap/draft beers and red wines) should be avoided when taking Trima 300mg Tablet, as it may cause an unsafe rise in your blood pressure.
  • Inform your doctor if you notice sudden mood changes or develop suicidal thoughts.
  • Do not stop taking the medication suddenly without talking to your doctor.

Safety advice

Alcohol

Alcohol

CAUTION
Alcohol should be used with caution while taking Trima 300mg Tablet.
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
Trima 300mg Tablet is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Trima 300mg Tablet may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.
Driving

Driving

UNSAFE
Trima 300mg Tablet may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney

Kidney

SAFE IF PRESCRIBED
Trima 300mg Tablet is safe to use in patients with kidney disease. No dose adjustment is recommended.
Liver

Liver

CAUTION
Trima 300mg Tablet should be used with caution in patients with liver disease. Dose adjustment may be needed.

Interaction with drugs

Taking Trima with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Life-threatening

Dextromethorphan Hydrobromide (Oral Route)

Do not consume Moclobemide with Dextromethorphan Hydrobromide. Moclobemide may decrease the metabolism of Dextromethorphan Hydrobromide.
Life-threatening

Amitriptyline (Oral Route)

Do not consume Moclobemide with Amitriptyline. If Moclobemide is essential, ensure a gap of at least 1 day after discontinuing Amitriptyline. Please consult your doctor.
Life-threatening

Bupropion (Oral Route)

Do not consume Moclobemide with Bupropion. If Moclobemide is essential, ensure a gap of at least 24 hours after discontinuing Bupropion. Please consult your doctor.
Life-threatening

Citalopram (Oral Route)

Do not consume Moclobemide with Citalopram. If Moclobemide is essential, ensure a gap of at least 1 week after discontinuing Citalopram. Please consult your doctor.
Life-threatening

Clomipramine (Oral Route)

Do not consume Moclobemide with Clomipramine. If Moclobemide is essential, ensure a gap of at least 1 day after discontinuing Clomipramine. Please consult your doctor.

Frequently asked questions

Trima 300mg Tablet is an antidepressant that is used to treat depression and improves your mood.
Trima 300mg Tablet may take from a few days to several weeks to be really effective. The length of the treatment will depend on how quickly your symptoms improve. Most antidepressants take time to work so don't be discouraged if you don't feel better right away.
Trima 300mg Tablet should be taken morning and evening at the end of your meal.
Dry mouth may occur as a side effect. Frequent mouth rinses, good oral hygiene, increased water intake, and sugarless candy may help.
No, Trima 300mg Tablet is not recommended for children since its safety is not established in this population.
Trima 300mg Tablet may cause eye pain, changes in vision, or swelling or redness in or around the eye. Seek immediate medical help if you notice such symptoms.
Trima 300mg Tablet may cause blurred vision or make some people drowsy or less alert than they are normally. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that requires mental alertness and vision.
Yes, headache is one of the side effects of Trima 300mg Tablet. Take rest and drink plenty of water and ask a pharmacist to recommend a suitable painkiller. If the headache continues, speak with your doctor.
Yes, Trima 300mg Tablet may cause constipation. Try to eat a well-balanced diet with lots of fibre and drink plenty of water. Do not take any laxatives without consulting your doctor.
Nausea and vomiting are some of the common side effects of this medicine. Eat smaller, more frequent meals to reduce the feeling of nausea. Avoid food that is salty, spicy, fried, or fatty.
Yes, Trima 300mg Tablet may cause a feeling of light-headedness and faintness. Do not stand up too quickly and try to lie down when you see it coming on.
Trima 300mg Tablet is non addictive
Trima 300mg Tablet has no sedative properties
Trima 300mg Tablet targets norepinephrine, serotonin and, to a lesser extent, dopamine neurotransmitter
Trima 300mg Tablet may cause these side effects. Call your doctor if you experience any unusual problems during your treatment.

Fact Box

Chemical Class

4- halobenzoic acid derivative

Habit Forming

No

Therapeutic Class

NEURO CNS

Action Class

Monoamine Oxidase (MAO) Inhibitors

References

  1. Stahl SM, editor. Moclobemide. In: Stahl's Essential Pschopharmacology: Prescriber's Guide. 5th ed. New York, New York: Cambridge University Press; 2014. pp. 447-52.
  2. Moclobemide. Hertfordshire, UK: Mylan Products Limited; 2009 [revised Feb. 2018]. [Accessed 25 Mar. 2019] (online) Available from:
  3. Central Drugs Standard Control Organisation (CDSCO). [Accessed 25 Mar. 2019] (online) Available from:
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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Intas Pharmaceuticals Ltd
Address: Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India.

Vendor Details

Country of origin: India

Lab tests offered by us

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Most medicines cannot be sold without a valid prescription, as per the Drugs and Cosmetics Act, 1940 and Rules, 1945
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