Clomipramine

Last updated 25 Nov 2025 | 09:34 AM (UTC)

Clomipramine Uses

Clomipramine is used in the treatment of depression, obsessive-compulsive disorder and phobia.

How Clomipramine works

Clomipramine works by increasing the activity of serotonin, a natural chemical messenger in the brain that influences mood, thoughts, and behavior. It blocks the reuptake of serotonin into nerve cells, which helps keep more of it available between brain cells. This action helps reduce obsessive thoughts, lessen compulsive behaviors, ease anxiety from phobias, and improve mood in depression.

Common side effects of Clomipramine

Dryness in mouth, Constipation, Nausea, Indigestion, Decreased appetite, Sleepiness, Tremors, Dizziness, Nervousness, Myoclonus, Altered libido, Ejaculation disorder, Impotence, Micturition disorders, Fatigue, Increased sweating, Increased appetite, Weight gain, Altered vision

Want to Know More

Read Our Editorial Policy

Medicine brands for Clomipramine

Clofranil

Sun Pharmaceutical Industries Ltd

₹65 to ₹189

3 variant(s)

CLOnil

Intas Pharmaceuticals Ltd

Triko Pharmaceuticals

₹29 to ₹154

4 variant(s)

Clomistar

Gentech Healthcare Pvt Ltd

₹45 to ₹100

3 variant(s)

Cloclam

Aurum Life Science Pvt Ltd

₹52 to ₹79

2 variant(s)

Clomine

Psychotropics India Ltd

₹18 to ₹103

2 variant(s)

Clomivon

Shine Pharmaceuticals Ltd

₹31 to ₹31

1 variant(s)

Clomip

Reliance Formulation Pvt Ltd

₹23 to ₹61

3 variant(s)

Expert advice for Clomipramine

Take Clomipramine at the same time every day to build a routine and avoid missed doses.
Do not stop the medicine suddenly, even if you feel better; always consult your doctor before making changes.
Avoid driving or operating heavy machines until you know how it affects you, as Clomipramine may cause drowsiness.
Limit or avoid alcohol, as it can increase drowsiness and side effects.
Make sure to attend all follow-up visits with the doctor to monitor your dose and progress.

Frequently asked questions for Clomipramine

Q. What is Clomipramine and what does it treat?

Clomipramine is a tricyclic antidepressant used to treat obsessive-compulsive disorder (OCD), phobic states, and depression (when sedation is helpful). It is often prescribed when obsessive thoughts, intense fears, or depressed mood interfere with daily life.

Q. How long before I notice improvement?

Some people may notice early improvements in a few weeks, but meaningful benefit for OCD or depression often takes 6–12 weeks, and full effects can take longer. Steady drug levels may take 1–3 weeks after dose changes. Continue taking it for as long as prescribed and do not stop it suddenly.

Q. How should I take it?

Take it exactly as your doctor prescribes. Treatment usually starts at a low dose and is increased gradually to reduce side effects. Take doses with meals if advised; this will help reduce upset stomach. Take it at the same time each day and ensure to attend all follow-up visits so your doctor can review your dose and response.

Q. Are there any serious risks I should know about?

Yes. Clomipramine may cause seizures, heart rhythm problems, and can increase suicidal thoughts in young people early in treatment. Do not use it with MAO inhibitors or within 14 days of stopping them due to the risk of life-threatening serotonin syndrome. Get urgent help for new suicidal thoughts, fainting, chest pain, severe heartbeat changes, or signs of serotonin syndrome like high fever, stiff muscles, or confusion.