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    Information about Clomipramine

    Clomipramine uses

    Clomipramine is used in the treatment of obsessive-compulsive disorder. It is used in patients intolerant of or unresponsive to alternative treatment options for depression.

    How clomipramine works

    Clomipramine is a tricyclic antidepressant. It increases the levels of chemical messengers in the brain that help in regulating the mood and treat depression.

    Common side effects of clomipramine

    Constipation, Dryness in mouth, Sleepiness, Indigestion, Altered libido, Ejaculation disorder, Abnormal micturition frequency
    Content Details
    Written By
    Dr. Swati Mishra
    Reviewed By
    Dr. Ashish Ranjan
    MD (Pharmacology), MBBS
    Last updated on:
    23 Jan 2020 | 11:35 AM (IST)
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    Read Our Editorial Policy

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    Expert advice for Clomipramine

    • It may take 4 to 6 weeks for Clomipramine to start working. Keep taking it as prescribed.
    • It may cause sleepiness. Take it at bedtime and do not drive or do anything requiring concentration until you know how it affects you.
    • Avoid consuming alcohol when taking Clomipramine as it may cause excessive sleepiness.
    • Monitor your weight during the treatment as this medicine can cause weight gain and increased appetite.
    • Talk to your doctor if you notice sudden mood changes or develop suicidal thoughts.

    Frequently asked questions for Clomipramine


    Q. Can Clomipramine cause impotence?

    Yes, Clomipramine can cause impotence. Both men and women may experience decreased sexual desire and inability to have an organsm. In males, difficulty in maintaining erection (impotence) or painful ejaculation may be observed. You should consult your doctor immediately if you face any such problems while taking Clomipramine.

    Q. Is Clomipramine safe?

    Yes, Clomipramine is safe to use if taken in the dose and duration as prescribed by the doctor. Clomipramine is a medicine that treats Obsessive-Compulsive Disorder (OCD), stabilises mood and behavior. Thus, it restores the chemical imbalance in the brain and creates a feeling of well being.

    Q. What are the side effects of Clomipramine?

    The side effects of Clomipramine are abnormal micturition frequency, altered libido, constipation, dryness in mouth, ejaculation disorder, indigestion, and sleepiness. Please consult your doctor if these side effects worry you, to know about ways of treating or preventing them.

    Q. What happens if I overdose?

    If you have taken an overdose of Clomipramine, you may experience symptoms such as drowsiness, restlessness, agitation, delirium, severe sweating, fast heartbeat, fainting, seizures (fits), and you may even go into a state of coma. If you think you have taken too much of this medicine please get emergency medical help.

    Q. If I am feeling good, can I stop taking Clomipramine?

    No, you must not stop taking Clomipramine suddenly even if you are feeling good as it may worsen your existing symptoms and also cause withdrawal symptoms such as dizziness, nausea, vomiting, headache, weakness, sleep problems, fever, and irritability. Continue taking Clomipramine for the duration as prescribed by your doctor to get maximum benefit. If you are not able to tolerate a dose or if you have completed your course of treatment, your doctor will reduce your dose gradually before taking you off this medicine completely.

    Content on this page was last updated on 23 January, 2020, by Dr. Varun Gupta (MD Pharmacology)