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Clomipramine is used in the treatment of depression and obsessive-compulsive disorder

How it works

Clomipramine increases the levels of chemical messengers in the brain that help in regulating the mood and treat depression.

Common side effects

Sleepiness, Blurred vision, Dry mouth, Difficulty in urination, Constipation, Orthostatic hypotension (sudden lowering of blood pressure on standing), Weight gain, Increased heart rate

Available Medicine

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    Intas Pharmaceuticals Ltd
    4 variant(s)
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    Sun Pharmaceutical Industries Ltd
    4 variant(s)
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    Talent Healthcare
    3 variant(s)
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    La Pharmaceuticals
    3 variant(s)
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    Triko Pharmaceuticals
    3 variant(s)
  • ₹75
    Zenith Healthcare Ltd
    1 variant(s)
  • ₹20 to ₹107
    Psychotropics India Ltd
    2 variant(s)
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    Aurum Life Science Pvt Ltd
    2 variant(s)
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    Sigmund Promedica
    3 variant(s)
  • ₹20 to ₹63
    Reliance Formulation Pvt Ltd
    3 variant(s)

Expert advice

  • Do not start or continue clomipramine tablets, if you are allergic (hypersensitive) to tricyclic antidepressants, clomipramine or any of the other ingredients of clomipramine medication.
  • Do not take clomipramine if you have history of suicide-related events.
  • Avoid using clomipramine if you are pregnant or breast feeding.
  • Advice care givers to monitor the patient carefully.
  • Doctor’s advice should be considered in case of following disease conditions: heart disorders, serotonin syndrome, fits (convulsions), increased pressure inside the eye causing visual problems (narrow angle glaucoma), urinary retention, liver disease, and chronic constipation.

Frequently asked questions



Is clomipramine safe?
Clomipramine is safe if used at prescribed dose and duration as advised by your doctor


Is clomipramine a MAOI/anticholinergic/benzodiazepine/SSRI/narcotic?
Clomipramine is tricyclic antidepressant. It treats depression through inhibiting the neuronal re-uptake of chemical substances present in the brain called noradrenaline and mainly serotonin (SSRI). It is not MAOI/anticholinergic/benzodiazepine/narcotic


Is clomipramine a controlled substance?
No, it is not a controlled substance

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Is clomipramine addictive?
Clomipramine is not addictive if used at prescribed dose and duration as advised by your doctor


Can I take paracetamol/diazepam/5htp with clomipramine?
Taking other medicines may alter the effects of clomipramine. Always consult your doctor for the change of dose regimen or an alternative drug of choice that may strictly be required


Does clomipramine cause weight loss/weight gain/make you sleepy/cause constipation/affect fertility?
Clomipramine may cause these side effects; effect on fertility is very rare side effect. However, consult your doctor if you experience any of these side effects


Does clomipramine help premature ejaculation?
Clomipramine effectively increases ejaculatory latency in men with primary premature ejaculation, while treatment is not effective in those with premature ejaculation and erectile dysfunction


Does clomipramine work for obsessive-compulsive disorder (OCD)?
Yes, clomipramine is used for obsessive-compulsive disorder. Patients should follow the advice of the doctor regarding its use.

Content on this page was last updated on 07 March, 2017, by Dr. Varun Gupta (MD Pharmacology)