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Clomipramine is used in the treatment of depression

How it works

Clomipramine works in depression by increasing the levels of chemical messengers in the brain that helps in regulating mood.

Common side effects

Neuroleptic malignant syndrome, Nightmare, Orthostatic hypotension (sudden lowering of blood pressure on standing), Palpitations, Increased sensitivity to light, Pneumonitis, Increased white blood cell count (eosinophils), Liver enzyme increased, Gastrointestinal discomfort, Abnormal heart rhythm, Abnormal milky discharge from breast, Activation of psychotic symptoms, Acute confusional state, Aggravation of depression, Aggression, Agitation, Allergic reaction, Anaphylactic reaction, Decreased blood pressure, Anxiety, Blurred vision, Breast enlargement, Bruise, Convulsion, Depersonalisation (feelings of being outside the body), Diarrhoea, Dilation of the pupil of the eye, Disorientation (alteration of mental status), Difficulty in paying attention, Dizziness, Altered taste, Difficulty in urination, Ecg changes, Eeg changes, Erectile dysfunction, Fatigue, Hair loss, Headache, Hepatitis (viral infection of liver), Jaundice, High grade fever, Hot flashes, Hypomania, Inability to empty the urinary bladder, Increase in body weight, Increased appetite, Increased blood pressure, Visual disorder, Increased intraocular pressure, Increased sweating, Insomnia, Itching, Loss of appetite, Extremes of being happy or sad, Memory impairment, Muscle damage, Muscle twitching, Muscle weakness, Restlessness, Ringing in ear, Skin bleeding, Sleep disorder, Sleepiness, Speech disorder, Swelling, Syndrome of inappropriate antidiuretic hormone secretion, Tremor, Unsteadiness, Auditory hallucination, Visual hallucination, Vomiting, Yawning, Abnormal sensation in skin, Altered sexual function

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Expert advice

  • Do not start or continue clomipramine tablets, if you are allergic (hypersensitive) to tricyclic antidepressants, clomipramine or any of the other ingredients of clomipramine medication.
  • Do not take clomipramine if you have history of suicide-related events.
  • Avoid using clomipramine if you are pregnant or breast feeding.
  • Advice care givers to monitor the patient carefully.
  • Doctor’s advice should be considered in case of following disease conditions: heart disorders, serotonin syndrome, fits (convulsions), increased pressure inside the eye causing visual problems (narrow angle glaucoma), urinary retention, liver disease, and chronic constipation.

Frequently asked questions


Q. Is clomipramine safe?
Clomipramine is safe if used at prescribed dose and duration as advised by your doctor

Q. Is clomipramine a MAOI/anticholinergic/benzodiazepine/SSRI/narcotic?
Clomipramine is tricyclic antidepressant. It treats depression through inhibiting the neuronal re-uptake of chemical substances present in the brain called noradrenaline and mainly serotonin (SSRI). It is not MAOI/anticholinergic/benzodiazepine/narcotic

Q. Is clomipramine a controlled substance?
No, it is not a controlled substance

Q. Is clomipramine addictive?
Clomipramine is not addictive if used at prescribed dose and duration as advised by your doctor

Q. Can I take paracetamol/diazepam/5htp with clomipramine?
Taking other medicines may alter the effects of clomipramine. Always consult your doctor for the change of dose regimen or an alternative drug of choice that may strictly be required

Q. Does clomipramine cause weight loss/weight gain/make you sleepy/cause constipation/affect fertility?
Clomipramine may cause these side effects; effect on fertility is very rare side effect. However, consult your doctor if you experience any of these side effects

Q. Does clomipramine help premature ejaculation?
Clomipramine effectively increases ejaculatory latency in men with primary premature ejaculation, while treatment is not effective in those with premature ejaculation and erectile dysfunction

Q. Does clomipramine work for obsessive-compulsive disorder (OCD)?
Yes, clomipramine is used for obsessive-compulsive disorder. Patients should follow the advice of the doctor regarding its use.

Content on this page was last updated on 09 January, 2017, by Dr. Varun Gupta (MD Pharmacology)