Topline 50 Tablet
Prescription Required
Product introduction
Topline 50 Tablet is a medicine used to treat epilepsy (seizures) and to prevent migraines. It is also used in the treatment of Lennox-Gastaut syndrome (a rare, but severe form of epilepsy that starts in early childhood).
Topline 50 Tablet may be taken with or without food, preferably at the same time, each day. If you have missed a dose, take it as soon as you remember it and finish the full course of treatment even if you feel better. Stopping the medication suddenly without talking to your doctor may cause an increased frequency of seizures. Your doctor may advise regular monitoring of serum bicarbonate levels while you are taking this medicine.
Some of the common side effects of this medicine include nausea, taste change, fatigue, diarrhea, weight loss, loss of appetite, and memory impairment. It may also cause vision problems like myopia or glaucoma, so it is important to get your eyesight checked before you start the treatment and regularly thereafter. You may experience dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you. Please consult your doctor if these side effects bother you or do not go away.
Uses of Topline Tablet
- Epilepsy
- Mania
- Epilepsy/Seizures
- Lennox–Gastaut syndrome
- Migraine
- Trigeminal neuralgia
- Seizures
Benefits of Topline Tablet
In Epilepsy/Seizures
Topline 50 Tablet is an anticonvulsant (or anti-epileptic) medicine that works by decreasing the nerve impulses which cause the seizures. By controlling the frequency of seizures, it will help you go about your daily activities with more confidence. It helps reduce symptoms such as confusion, uncontrollable jerking movements, loss of awareness, and fear or anxiety.
This medicine is not associated with any physical or psychological dependence (addiction) but it should not be stopped suddenly. It must be taken regularly as prescribed to be effective. Missing doses may trigger a seizure.
This medicine is not associated with any physical or psychological dependence (addiction) but it should not be stopped suddenly. It must be taken regularly as prescribed to be effective. Missing doses may trigger a seizure.
In Lennox–Gastaut syndrome
Lennox-Gastaut syndrome (LGS) is a rare but severe form of epilepsy that usually starts in early childhood. Affected children may experience several different types of seizures. Topline 50 Tablet helps prevent and control these seizures by decreasing the nerve impulses which cause the seizures.
Side effects of Topline Tablet
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Topline
- Abdominal pain
- Diarrhea
- Dizziness
- Fatigue
- Fever
- Loss of appetite
- Memory impairment
- Nausea
- Nervousness
- Numbness
- Psychomotor impairment
- Sleepiness
- Speech disorder
- Taste change
- Upper respiratory tract infection
- Visual impairment
- Weight loss
How to use Topline Tablet
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Topline 50 Tablet may be taken with or without food, but it is better to take it at a fixed time.
How Topline Tablet works
Topline 50 Tablet is an antiepileptic medication. It controls seizures or fits by decreasing the abnormal and excessive activity of the nerve cells in the brain.
Safety advice
Alcohol
UNSAFE
It is unsafe to consume alcohol with Topline 50 Tablet.
Pregnancy
CONSULT YOUR DOCTOR
Topline 50 Tablet is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
Breast feeding
CONSULT YOUR DOCTOR
Topline 50 Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Driving
UNSAFE
Topline 50 Tablet may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney
CAUTION
Topline 50 Tablet should be used with caution in patients with kidney disease. Dose adjustment of Topline 50 Tablet may be needed. Please consult your doctor.
Liver
CAUTION
Topline 50 Tablet should be used with caution in patients with liver disease. Dose adjustment of Topline 50 Tablet may be needed. Please consult your doctor.
What if you forget to take Topline Tablet?
If you miss a dose of Topline 50 Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
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Quick tips
- Take your medication regularly as directed by your doctor as missing doses can trigger seizures.
- Do not change the brand of your medicine and make sure that you have sufficient amount of medicine present with you.
- Some healthy tips to prevent seizures:
- Practice yoga every day.
- Get enough sleep at nighttime.
- Limit the use of screen time such as mobile/laptop.
- Take your medication on time.
- It may cause dizziness and sleepiness. Do not drive or do anything that requires mental focus until you know how it affects you.
- Keep yourself hydrated by drinking plenty of fluids throughout the day while taking Topline 50 Tablet. This can reduce the risk of kidney stones.
- Monitor your weight during treatment with this medicine as it can cause weight gain.
- Talk to your doctor if you notice sudden mood changes or develop suicidal thoughts.
- Do not stop taking the medication suddenly without talking to your doctor as it may increase the seizure frequency.
Fact Box
Chemical Class
Dioxolopyrans Derivative
Habit Forming
No
Therapeutic Class
NEURO CNS
Action Class
Sodium Channel Modulators- Antiepileptic drugs (AEDs)
Interaction with drugs
Taking Topline with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Concurrent use may increase the risk of breakthrough bleeding and contraceptive failure.
It is recommended to use barrier methods (like condoms), IUDs, or a depot for contraceptio
Concurrent use may increase the risk of breakthrough bleeding and contraceptive failure.
It is recommended to use barrier methods (like condoms), IUDs, or a depot for contraceptio
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Orlistat may reduce efficacy of Topiramate.
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Topiramate may reduce blood levels and efficacy of Imatinib mesylate.
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Patient concerns
FAQs
For how long do I need to take Topline 50 Tablet?
The dose and duration of this medicine will depend on your doctor’s advice. Topline 50 Tablet does not cure your condition (seizures/migraine) but prevents them from occurring. So, you may have to keep taking it for months or years depending on improvement in your symptoms and side effects that may occur.
Is Topline 50 Tablet good for anxiety?
Topline 50 Tablet is not indicated for the treatment of anxiety. Please consult your doctor before taking the medicine.
What are the serious side effects of Topline 50 Tablet?
Serious side effects of Topline 50 Tablet are rare. The serious effects of Topline 50 Tablet may include glaucoma (difficulty in seeing, eye pain, and blurred vision), kidney stones (sharp pain in your sides or lower back), and metabolic acidosis (tiredness, loss of appetite, irregular and faint heartbeat). Other serious side effects of Topline 50 Tablet could be suicidal thoughts and insufficient sweating (some children taking Topline 50 Tablet may not sweat enough in hot weather, causing their body temperatures to rise).
I am taking valproic acid for fits. Will Topline 50 Tablet interfere with the working of valproic acid? Can this combination be taken?
Topline 50 Tablet does not interfere with the working of valproic acid, but it increases the risk of getting excess levels of ammonia in the blood (hyperammonemia). Increased levels of ammonia in the blood can be dangerous and may cause difficulty in thinking, remembering information, or solving problems. It may also decrease your alertness and make you feel very sleepy with low energy. Immediately inform your doctor if you notice these symptoms. It is important to know that, in rare cases, Topline 50 Tablet alone can cause hyperammonemia.
Can Topline 50 Tablet be used in children?
Yes, Topline 50 Tablet is used for seizures in children more than 2 years of age. However, because of the lack of any reports, this medicine is not recommended to be used in children for migraines.
Since I have started using Topline 50 Tablet people are saying that I have lost weight. Is it because of Topline 50 Tablet or something else for which I should get investigated?
It could be due to Topline 50 Tablet because Topline 50 Tablet commonly causes weight loss probably due to a decrease in appetite. If you still have any doubts, talk to your doctor who will advise you appropriately.
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Disclaimer:
Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.References
- Stahl SM, editor. Topiramate. In: Stahl's Essential Pschopharmacology: Prescriber's Guide. 5th ed. New York, New York: Cambridge University Press; 2014. pp. 669-73.
- McNamara JO. Pharmacotherapy of the Epilepsies. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 601.
- Porters RJ, Meldrum BS. Antiseizure Drugs. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 12.
- Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1380-82.
- Topiramate. High Wycombe, Bucks: Janssen-Cilag Ltd.; 1995 [revised 13 Dec. 2017]. [Accessed 22 Jan. 2019] (online) Available from:
- Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Topiramate. [Updated 2020 Jan 20]. [Accessed 20 Feb. 2020] (online) Available from:
- Topiramate. Gurabo, Puerto Rico: Janssen Ortho; 2012. [Accessed 18 Mar. 2019] (online) Available from:
- Central Drugs Standard Control Organisation (CDSCO). [Accessed 19 Mar. 2019] (online) Available from:
- Topiramate [Prescribing Information]. 2012. Titusville, NJ: Janssen Pharmaceuticals, Inc.; 2009. [Accessed 20 Feb. 2024] (online) Available from:
Marketer details
Name: Chinar Therapeutics Pvt.&Ltd.
Address: Transport Nagar,Balicha - Udaipur 313604 (Raj.)
Country of origin: India
The list of available options shown with the same composition has been prepared upon the advice of registered medical practitioners, pharmacists affiliated with TATA 1MG. TATA 1MG does not promote any pharmaceutical product of any particular company, and all recommendations are based on the medical opinion, advisories from specialist medical and pharmaceutical professionals.
The list of available options shown with the same composition has been prepared upon the advice of registered medical practitioners, pharmacists affiliated with TATA 1MG. TATA 1MG does not promote any pharmaceutical product of any particular company, and all recommendations are based on the medical opinion, advisories from specialist medical and pharmaceutical professionals.
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