Topamate 25mg Tablet is a medicine used to treat epilepsy (seizures) and to prevent migraines. It is also used in the treatment of Lennox-Gastaut syndrome (a rare, but severe form of epilepsy that starts in early childhood).

Topamate 25mg Tablet may be taken with or without food, preferably at the same time, each day. If you have missed a dose, take it as soon as you remember it and finish the full course of treatment even if you feel better. Stopping the medication suddenly without talking to your doctor may cause an increased frequency of seizures. Your doctor may advise regular monitoring of serum bicarbonate levels while you are taking this medicine.

Some of the common side effects of this medicine include nausea, taste change, fatigue, diarrhea, weight loss, loss of appetite, and memory impairment. It may also cause vision problems like myopia or glaucoma, so it is important to get your eyesight checked before you start the treatment and regularly thereafter. You may experience dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you. Please consult your doctor if these side effects bother you or do not go away.

Uses of Topamate Tablet

Epilepsy/Seizures
Prevention of Migraine
Lennox–Gastaut syndrome

Benefits of Topamate Tablet

In Epilepsy/Seizures

Topamate 25mg Tablet is an anticonvulsant (or anti-epileptic) medicine that works by decreasing the nerve impulses which cause the seizures. By controlling the frequency of seizures, it will help you go about your daily activities with more confidence. It helps reduce symptoms such as confusion, uncontrollable jerking movements, loss of awareness, and fear or anxiety.
This medicine is not associated with any physical or psychological dependence (addiction) but it should not be stopped suddenly. It must be taken regularly as prescribed to be effective. Missing doses may trigger a seizure.

In Prevention of Migraine

It is not fully established how Topamate 25mg Tablet helps prevent migraines. It may change the abnormal and excessive activity of the nerve cells in the brain or increase the activity in a region of the brain associated with migraines. By preventing and reducing the frequency of headaches, it can help you carry out your daily activities and have a better quality of life.

In Lennox–Gastaut syndrome

Lennox-Gastaut syndrome (LGS) is a rare but severe form of epilepsy that usually starts in early childhood. Affected children may experience several different types of seizures. Topamate 25mg Tablet helps prevent and control these seizures by decreasing the nerve impulses which cause the seizures.

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Side effects of Topamate Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Topamate

Abdominal pain
Diarrhea
Dizziness
Fatigue
Fever
Loss of appetite
Memory impairment
Nausea
Nervousness
Numbness
Psychomotor impairment
Sleepiness
Speech disorder
Taste change
Upper respiratory tract infection
Visual impairment
Weight loss

How to use Topamate Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Topamate 25mg Tablet may be taken with or without food, but it is better to take it at a fixed time.

How Topamate Tablet works

Topamate 25mg Tablet is an antiepileptic medication. It controls seizures or fits by decreasing the abnormal and excessive activity of the nerve cells in the brain.

Safety advice

Alcohol

UNSAFE

It is unsafe to consume alcohol with Topamate 25mg Tablet.

Pregnancy

CONSULT YOUR DOCTOR

Topamate 25mg Tablet is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.

Breast feeding

CONSULT YOUR DOCTOR

Topamate 25mg Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

Driving

UNSAFE

Topamate 25mg Tablet may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Kidney

CAUTION

Topamate 25mg Tablet should be used with caution in patients with kidney disease. Dose adjustment of Topamate 25mg Tablet may be needed. Please consult your doctor.

Liver

CAUTION

Topamate 25mg Tablet should be used with caution in patients with liver disease. Dose adjustment of Topamate 25mg Tablet may be needed. Please consult your doctor.

What if you forget to take Topamate Tablet?

If you miss a dose of Topamate 25mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.

Topamate 25mg Tablet

₹3.71/Tablet

Topaz 25 Tablet

Intas Pharmaceuticals Ltd

₹6.47/tablet

74% costlier

Topamac 25mg Tablet

Janssen Pharmaceuticals

₹11.8/tablet

218% costlier

Topirol 25 Tablet

Sun Pharmaceutical Industries Ltd

₹9.02/tablet

143% costlier

Leptomate 25 Tablet

La Renon Healthcare Pvt Ltd

₹4.14/tablet

12% costlier

Nextop 25 Tablet

Torrent Pharmaceuticals Ltd

₹8.16/tablet

120% costlier

View all substitutes

Quick tips

Take your medication regularly as directed by your doctor as missing doses can trigger seizures.
Do not change the brand of your medicine and make sure that you have sufficient amount of medicine present with you.
Some healthy tips to prevent seizures:
- Practice yoga every day.
- Get enough sleep at nighttime.
- Limit the use of screen time such as mobile/laptop.
- Take your medication on time.
It may cause dizziness and sleepiness. Do not drive or do anything that requires mental focus until you know how it affects you.
Keep yourself hydrated by drinking plenty of fluids throughout the day while taking Topamate 25mg Tablet. This can reduce the risk of kidney stones.
Monitor your weight during treatment with this medicine as it can cause weight gain.
Talk to your doctor if you notice sudden mood changes or develop suicidal thoughts.
Do not stop taking the medication suddenly without talking to your doctor as it may increase the seizure frequency.

Fact Box

Chemical Class

Dioxolopyrans Derivative

Habit Forming

Therapeutic Class

NEURO CNS

Action Class

Sodium channel modulators (AED)

Interaction with drugs

Taking Topamate with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Alprazolam

Brand(s): Eurolam, Alwel, Tenzo

Serious

Carbamazepine

Brand(s): Antep, C Lep, Ametol

Serious

Chlordiazepoxide

Brand(s): Equblam, Raipox, Equiliser

Serious

Clobazam

Brand(s): Risure

Serious

View all interactions

Patient concerns

She has problem of epilepsy from last two years

Dr. Rahul Yadav

Paediatrics

Hello, epilepsy and seizures cannot be treated online without physically examining the child and detailed history.

I m taking 1.5gm sodium valporate,1.5 levectram, 1gm clobezam then also seizure r their at period of weekly is there alternate treatment in Ayurveda as every time at multiplying the doses at every visit As MRI eeg every tests r normal

Dr. M. K. Ansari

Neurology

not aware of any ayurvedic medications for epilepsy is not my specialization. However you seems to have difficult to control (intractable) seizures plz follow doctors advice deligently for ur own welfare

?? ???? ?????? ?? ?????? ?? ?? ??? encorate Charon 200 500 tablet use krta hu kya iska koi solution h Jisse main completely thk ho jau

Dr. Jyoti Kapoor Madan

Psychiatry

Epilepsy requires regular treatment with anticonvulsants like encorate chrono for at least 3 years of seizure free period after which medicines may be tapered off unless seizures reappear. At present, there are no other effective treatment options.

Hi I am suffering from epilepsy from the past 1.5 years but before that I have no issues with my health the symptoms are I will get vomiting sensation from evening & heavy body pains & fits will comes only in early morning from 4 & 5 am i will get un concious for about 20 or 30 minutes & I will bite my tongue & after that I will have heavy nerve pains for a day or two from 5 days I am taking encorte 500 tablets between day & night before that I used to take homeopathy treatment

Dr. Jyoti Kapoor Madan

Psychiatry

Epilepsy is a central nervous system disorder (neurological disorder) in which nerve cell activity in the brain becomes disrupted, causing seizures or periods of unusual behavior, sensations and sometimes loss of consciousness. Medicines for epilepsy are initially recommended for at least 3 years of seizure free interval but may continue longer depending on recurrence. Epileptic patient needs to carry a warning card or a medical emergency bracelet with identification details, his/ her epilepsy status and what people can do if fit occurs in public place.

I am Epilepsy peshent said u take tab Phen Phen 50 up to 3 to 5 years

Dr. Jyoti Kapoor Madan

Psychiatry

User feedback

Patients taking Topamate 25mg Tablet

Once A Day

55%

Twice A Day

36%

Thrice A Day

FAQs

Q. For how long do I need to take Topamate 25mg Tablet?

The dose and duration of this medicine will depend on your doctor’s advice. Topamate 25mg Tablet does not cure your condition (seizures/migraine) but prevents them from occurring. So, you may have to keep taking it for months or years depending on improvement in your symptoms and side effects that may occur.

Q. Is Topamate 25mg Tablet good for anxiety?

Topamate 25mg Tablet is not indicated for the treatment of anxiety. Please consult your doctor before taking the medicine.

Q. What are the serious side effects of Topamate 25mg Tablet?

Serious side effects of Topamate 25mg Tablet are rare. The serious effects of Topamate 25mg Tablet may include glaucoma (difficulty in seeing, eye pain, and blurred vision), kidney stones (sharp pain in your sides or lower back), and metabolic acidosis (tiredness, loss of appetite, irregular and faint heartbeat). Other serious side effects of Topamate 25mg Tablet could be suicidal thoughts and insufficient sweating (some children taking Topamate 25mg Tablet may not sweat enough in hot weather, causing their body temperatures to rise).

Q. I am taking valproic acid for fits. Will Topamate 25mg Tablet interfere with the working of valproic acid? Can this combination be taken?

Topamate 25mg Tablet does not interfere with the working of valproic acid, but it increases the risk of getting excess levels of ammonia in the blood (hyperammonemia). Increased levels of ammonia in the blood can be dangerous and may cause difficulty in thinking, remembering information, or solving problems. It may also decrease your alertness and make you feel very sleepy with low energy. Immediately inform your doctor if you notice these symptoms. It is important to know that, in rare cases, Topamate 25mg Tablet alone can cause hyperammonemia.

Q. Can Topamate 25mg Tablet be used in children?

Yes, Topamate 25mg Tablet is used for seizures in children more than 2 years of age. However, because of the lack of any reports, this medicine is not recommended to be used in children for migraines.

Q. Since I have started using Topamate 25mg Tablet people are saying that I have lost weight. Is it because of Topamate 25mg Tablet or something else for which I should get investigated?

It could be due to Topamate 25mg Tablet because Topamate 25mg Tablet commonly causes weight loss probably due to a decrease in appetite. If you still have any doubts, talk to your doctor who will advise you appropriately.

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

Stahl SM, editor. Topiramate. In: Stahl's Essential Pschopharmacology: Prescriber's Guide. 5th ed. New York, New York: Cambridge University Press; 2014. pp. 669-73.
McNamara JO. Pharmacotherapy of the Epilepsies. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 601.
Porters RJ, Meldrum BS. Antiseizure Drugs. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 12.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1380-82.
Topiramate. High Wycombe, Bucks: Janssen-Cilag Ltd.; 1995 [revised 13 Dec. 2017]. [Accessed 22 Jan. 2019] (online) Available from:
Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Topiramate. [Updated 2020 Jan 20]. [Accessed 20 Feb. 2020] (online) Available from:
Topiramate. Gurabo, Puerto Rico: Janssen Ortho; 2012. [Accessed 18 Mar. 2019] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 19 Mar. 2019] (online) Available from:

Manufacturer

Name: Cipla Ltd

Address: Cipla House, Peninsula Business Park, Ganpatrao Kadam Marg, Lower Parel, Mumbai-400013

Country of origin: India

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