Tofirex 50 Tablet

Reviewed By Dr. Lalit Kanodia, MBA, MD Pharmacology

Last updated on 12 Nov 2025 | 11:03 PM (IST)

Tofirex 50 Tablet belongs to a class of medicines called benzodiazepines. It is used in the treatment of depression and anxiety associated with depression. It has a calming effect on the brain by relaxing the nerves, thus relieving the symptoms of anxiety.

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General Information

Contains

Tofisopam (50mg)

Marketer

Adivis Pharma Pvt Ltd

Storage

Store below 30°C

The content is shown in English

Product introduction

Tofirex 50 Tablet may be taken with or without food. However, take it at the same time each day as this helps to maintain a consistent level of medicine in the body. Take this medicine in the dose and duration as advised by your doctor as it has a high potential of habit-forming.

If you have missed a dose, take it as soon as you remember and finish the full course of treatment even if you feel better. It is important that this medication is not stopped suddenly without talking to your doctor as it may cause nausea and anxiety. It should only be used for a limited period as long-term use of this medicine is not recommended.

Tofirex 50 Tablet may cause loss of appetite, nausea, dry mouth, headaches, insomnia, and constipation. These are usually temporary and resolve on their own. Consult your doctor if these side effects bother you or do not go away. Do not operate heavy machinery or drive if you have taken this medicine until you know how it affects your body.

It should be noted that in elderly patients this medicine may reduce muscle tone and increased the risk of falls. You should avoid alcohol intake while taking this medicine as it will increase drowsiness. Please inform your doctor if you are pregnant, planning to conceive or breastfeeding, before taking this medicine.

Uses of Tofirex Tablet

Benefits of Tofirex Tablet

Treatment of Anxiety
Tofirex 50 Tablet reduces the symptoms of excessive anxiety and worry. It can also reduce feelings of restlessness, tiredness, difficulty concentrating, irritability, and sleep problems that often come with Anxiety Disorder. It will therefore help you go about your daily activities more easily and be more productive. Keep taking this medicine even if you feel well. Stopping suddenly can cause serious problems.

Treatment of Depression
Tofirex 50 Tablet increases the levels of certain chemicals in the brain that improve our mood and behavior. This creates a feeling of wellbeing, relieves anxiety, reduces tension, helps you sleep better, and increases your energy levels. It is an effective antidepressant but may cause drowsiness. You need to take it regularly as it is prescribed for it to be most effective and should not stop taking it suddenly, even if you feel better, as it may worsen your condition.

Side effects of Tofirex Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Tofirex

Loss of appetite
Nausea
Headache
Dryness in mouth
Insomnia (difficulty in sleeping)

How to use Tofirex Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Tofirex 50 Tablet may be taken with or without food.

How Tofirex Tablet works

Tofirex 50 Tablet is a benzodiazepine. It works by increasing the action of a chemical messenger (GABA) which suppresses the abnormal and excessive activity of the nerve cells in the brain.Tofirex 50 Tablet works by balancing certain chemical messengers in the brain, mainly dopamine and serotonin, which play key roles in mood and anxiety regulation. Unlike common anti-anxiety medicines, it does not cause sedation or muscle relaxation. It restores the balance, it helps reduce anxiety, improve mood, and promote mental calmness without affecting alertness or concentration.

Quick tips

The addiction / habit-forming potential of this medicine is very high. Take it only as per the dose and duration advised by your doctor
It may cause dizziness. Do not drive or do anything that requires mental focus until you know how this medicine affects you.
Avoid consuming alcohol as it may increase dizziness and drowsiness.
Inform your doctor if you are pregnant, planning to conceive or breastfeeding.
Do not stop taking medication suddenly without talking to your doctor as that may lead to nausea, anxiety, agitation, flu-like symptoms, sweating, tremor, and confusion.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Tofirex 50 Tablet. Please consult your doctor.

Pregnancy

UNSAFE

Tofirex 50 Tablet is highly unsafe during pregnancy. It can cause serious harm to the unborn baby, including birth defects and pregnancy loss. Do not use this medicine if you are pregnant or planning to become pregnant.

Breast feeding

UNSAFE

Tofirex 50 Tablet is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

Driving

CONSULT YOUR DOCTOR

It is not known whether Tofirex 50 Tablet alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Please consult your doctor.

Kidney

CONSULT YOUR DOCTOR

There is limited data available on the use of Tofirex 50 Tablet in patients with kidney disease. Please consult your doctor.

Liver

CONSULT YOUR DOCTOR

There is limited data available on the use of Tofirex 50 Tablet in patients with liver disease.

Interaction with drugs

Taking Tofirex with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Severe

Tramadol (Injection Route)

If concurrent use is essential, watch out for symptoms of Tofisopam side effects such as drowsiness, excessive sedation, tiredness, dizziness or slurred speech and consult your doctor if you experience them. They may adjust the dose of Tofisopam as per the observations. It is advised to avoid driving or undertaking other tasks requiring skill and alertness.

Severe

Clozapine (Oral Route)

If concurrent use is essential, watch out for symptoms such as dizziness, headaches, tremors, sleep disturbances or mood changes and consult your doctor if you experience them. They may adjust the doses as per the observations.

Severe

Tramadol (Oral Route)

Severe

Morphine (Oral Route)

Severe

Sirolimus (Injection Route)

Your doctor may monitor the effects of Sirolimus and adjust the doses as per the observations. Tofisopam may raise blood levels of Sirolimus.

Frequently asked questions

What is Tofirex 50 Tablet used for?

Tofirex 50 Tablet is mainly used to treat anxiety and stress-related symptoms without causing significant sedation. It helps improve mood, mental alertness, and overall daily functioning in people with anxiety disorders.

How does Tofirex 50 Tablet work for anxiety?

Tofirex 50 Tablet belongs to a unique class of medicines called benzodiazepines. Unlike traditional benzodiazepines, it reduces anxiety without causing strong drowsiness or affecting mental clarity, making it suitable for daytime use.

Can Tofirex 50 Tablet cause dependence or withdrawal symptoms?

Tofirex 50 Tablet has a lower risk of dependence compared to traditional anti-anxiety medicines, but long-term or high-dose use can still lead to dependence. It should only be stopped gradually under a doctor’s supervision.

Who should not take Tofirex 50 Tablet?

Individuals should not take Tofirex 50 Tablet if they are allergic to it, have severe liver problems, uncontrolled seizures, or certain rare genetic disorders related to sugar metabolism.

Can Tofirex 50 Tablet be taken with alcohol?

No, you should avoid alcohol while taking Tofirex 50 Tablet, as it can increase drowsiness, dizziness, and reduce mental alertness.

Does Tofirex 50 Tablet interact with other medicines?

Yes, Tofirex 50 Tablet can interact with medicines such as antipsychotics, antidepressants, anti-seizure medicines, and certain antibiotics. Always inform your doctor about all medicines and supplements you are taking.

Is Tofirex 50 Tablet safe for elderly patients?

Elderly patients should take Tofirex 50 Tablet with caution, as they may be more sensitive to its effects, including dizziness and changes in coordination, which can increase the risk of falls.

Can Tofirex 50 Tablet be used in patients with epilepsy?

Tofirex 50 Tablet may have some anti-seizure properties, but its use in epilepsy should be carefully monitored by a doctor, especially if combined with other anti-epileptic medicines.

What precautions should people with liver or kidney problems take before using Tofirex 50 Tablet?

Patients with liver or kidney impairment may need dose adjustments and close monitoring while taking Tofirex 50 Tablet to avoid side effects.

Can Tofirex 50 Tablet be used for depression?

Tofirex 50 Tablet is not an antidepressant, but it may be prescribed alongside antidepressants in patients who have both anxiety and depression to improve overall mood and reduce tension.

Fact Box

Chemical Class

Benzodiazepines

Habit Forming

Yes

Therapeutic Class

NEURO CNS

Action Class

Benzodiazepines

References

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Adivis Pharma Pvt Ltd
Address: P NO-19-WZ-5-A-1,Vishnu Garden, West Delhi, Delhi,India-110018

Vendor Details

Country of origin: India

Lab tests offered by us

Why we need a prescription?

Provide right medicines

Prescriptions are complex documents. We proof read and recheck at various steps to provide you the right medication in the correct form and dose

In accordance with the law

Most medicines cannot be sold without a valid prescription, as per the Drugs and Cosmetics Act, 1940 and Rules, 1945

Tofirex 50 Tablet

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General Information

Contains

Marketer

Storage

Product introduction

Uses of Tofirex Tablet

Benefits of Tofirex Tablet

Side effects of Tofirex Tablet

How to use Tofirex Tablet

How Tofirex Tablet works

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Tramadol (Injection Route)

Clozapine (Oral Route)

Tramadol (Oral Route)

Morphine (Oral Route)

Sirolimus (Injection Route)

Frequently asked questions

What is Tofirex 50 Tablet used for?

How does Tofirex 50 Tablet work for anxiety?

Can Tofirex 50 Tablet cause dependence or withdrawal symptoms?

Who should not take Tofirex 50 Tablet?

Can Tofirex 50 Tablet be taken with alcohol?

Does Tofirex 50 Tablet interact with other medicines?

Is Tofirex 50 Tablet safe for elderly patients?

Can Tofirex 50 Tablet be used in patients with epilepsy?

What precautions should people with liver or kidney problems take before using Tofirex 50 Tablet?

Can Tofirex 50 Tablet be used for depression?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

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