Toficalm 50 Tablet

Reviewed By Dr. Rajeev Sharma, MBA, MBBS

Last updated on 23 Jan 2026 | 10:15 AM (IST)

Toficalm 50 Tablet belongs to a class of medicines called benzodiazepines. It is used in the treatment of depression and anxiety associated with depression. It has a calming effect on the brain by relaxing the nerves, thus relieving the symptoms of anxiety.

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General Information

Contains

Tofisopam (50mg)

Marketer

Sun Pharmaceutical Industries Ltd

Storage

Store below 30°C

The content is shown in English

Product introduction

Toficalm 50 Tablet may be taken with or without food. However, take it at the same time each day as this helps to maintain a consistent level of medicine in the body. Take this medicine in the dose and duration as advised by your doctor as it has a high potential of habit-forming.

If you have missed a dose, take it as soon as you remember and finish the full course of treatment even if you feel better. It is important that this medication is not stopped suddenly without talking to your doctor as it may cause nausea and anxiety. It should only be used for a limited period as long-term use of this medicine is not recommended.

Toficalm 50 Tablet may cause loss of appetite, nausea, dry mouth, headaches, insomnia, and constipation. These are usually temporary and resolve on their own. Consult your doctor if these side effects bother you or do not go away. Do not operate heavy machinery or drive if you have taken this medicine until you know how it affects your body.

It should be noted that in elderly patients this medicine may reduce muscle tone and increased the risk of falls. You should avoid alcohol intake while taking this medicine as it will increase drowsiness. Please inform your doctor if you are pregnant, planning to conceive or breastfeeding, before taking this medicine.

Uses of Toficalm Tablet

Benefits of Toficalm Tablet

Treatment of Anxiety
Toficalm 50 Tablet reduces the symptoms of excessive anxiety and worry. It can also reduce feelings of restlessness, tiredness, difficulty concentrating, irritability, and sleep problems that often come with Anxiety Disorder. It will therefore help you go about your daily activities more easily and be more productive. Keep taking this medicine even if you feel well. Stopping suddenly can cause serious problems.

Treatment of Depression
Toficalm 50 Tablet increases the levels of certain chemicals in the brain that improve our mood and behavior. This creates a feeling of wellbeing, relieves anxiety, reduces tension, helps you sleep better, and increases your energy levels. It is an effective antidepressant but may cause drowsiness. You need to take it regularly as it is prescribed for it to be most effective and should not stop taking it suddenly, even if you feel better, as it may worsen your condition.

Side effects of Toficalm Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Toficalm

Loss of appetite
Nausea
Headache
Dryness in mouth
Insomnia (difficulty in sleeping)

How to use Toficalm Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Toficalm 50 Tablet may be taken with or without food.

How Toficalm Tablet works

Toficalm 50 Tablet is a benzodiazepine. It works by increasing the action of a chemical messenger (GABA) which suppresses the abnormal and excessive activity of the nerve cells in the brain.Toficalm 50 Tablet works by balancing certain chemical messengers in the brain, mainly dopamine and serotonin, which play key roles in mood and anxiety regulation. Unlike common anti-anxiety medicines, it does not cause sedation or muscle relaxation. It restores the balance, it helps reduce anxiety, improve mood, and promote mental calmness without affecting alertness or concentration.

Quick tips

The addiction / habit-forming potential of this medicine is very high. Take it only as per the dose and duration advised by your doctor
It may cause dizziness. Do not drive or do anything that requires mental focus until you know how this medicine affects you.
Avoid consuming alcohol as it may increase dizziness and drowsiness.
Inform your doctor if you are pregnant, planning to conceive or breastfeeding.
Do not stop taking medication suddenly without talking to your doctor as that may lead to nausea, anxiety, agitation, flu-like symptoms, sweating, tremor, and confusion.

Safety advice

Alcohol

UNSAFE

Do not drink alcohol while you are taking this medicine. Toficalm 50 Tablet may cause excessive drowsiness when taken with alcohol.

Pregnancy

CONSULT YOUR DOCTOR

Toficalm 50 Tablet is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.

Breast feeding

CONSULT YOUR DOCTOR

Information regarding the use of Toficalm 50 Tablet during breastfeeding is not available. Please consult your doctor.

Driving

SAFE

Toficalm 50 Tablet does not usually affect your ability to drive.

Kidney

CAUTION

Toficalm 50 Tablet should be used with caution in patients with kidney disease. Dose adjustment may be needed.

Liver

CAUTION

Toficalm 50 Tablet should be used with caution in patients with liver disease. Dose adjustment may be needed.

Interaction with drugs

Taking Toficalm with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Severe

Tramadol (Injection Route)

If concurrent use is essential, watch out for symptoms of Tofisopam side effects such as drowsiness, excessive sedation, tiredness, dizziness or slurred speech and consult your doctor if you experience them. They may adjust the dose of Tofisopam as per the observations. It is advised to avoid driving or undertaking other tasks requiring skill and alertness.

Severe

Clozapine (Oral Route)

If concurrent use is essential, watch out for symptoms such as dizziness, headaches, tremors, sleep disturbances or mood changes and consult your doctor if you experience them. They may adjust the doses as per the observations.

Severe

Tramadol (Oral Route)

Severe

Morphine (Oral Route)

Severe

Sirolimus (Injection Route)

Your doctor may monitor the effects of Sirolimus and adjust the doses as per the observations. Tofisopam may raise blood levels of Sirolimus.

Frequently asked questions

What is Toficalm 50 Tablet used for?

Toficalm 50 Tablet is mainly used to treat anxiety and stress-related symptoms without causing significant sedation. It helps improve mood, mental alertness, and overall daily functioning in people with anxiety disorders.

How does Toficalm 50 Tablet work for anxiety?

Toficalm 50 Tablet belongs to a unique class of medicines called benzodiazepines. Unlike traditional benzodiazepines, it reduces anxiety without causing strong drowsiness or affecting mental clarity, making it suitable for daytime use.

Can Toficalm 50 Tablet cause dependence or withdrawal symptoms?

Toficalm 50 Tablet has a lower risk of dependence compared to traditional anti-anxiety medicines, but long-term or high-dose use can still lead to dependence. It should only be stopped gradually under a doctor’s supervision.

Who should not take Toficalm 50 Tablet?

Individuals should not take Toficalm 50 Tablet if they are allergic to it, have severe liver problems, uncontrolled seizures, or certain rare genetic disorders related to sugar metabolism.

Can Toficalm 50 Tablet be taken with alcohol?

No, you should avoid alcohol while taking Toficalm 50 Tablet, as it can increase drowsiness, dizziness, and reduce mental alertness.

Does Toficalm 50 Tablet interact with other medicines?

Yes, Toficalm 50 Tablet can interact with medicines such as antipsychotics, antidepressants, anti-seizure medicines, and certain antibiotics. Always inform your doctor about all medicines and supplements you are taking.

Is Toficalm 50 Tablet safe for elderly patients?

Elderly patients should take Toficalm 50 Tablet with caution, as they may be more sensitive to its effects, including dizziness and changes in coordination, which can increase the risk of falls.

Can Toficalm 50 Tablet be used in patients with epilepsy?

Toficalm 50 Tablet may have some anti-seizure properties, but its use in epilepsy should be carefully monitored by a doctor, especially if combined with other anti-epileptic medicines.

What precautions should people with liver or kidney problems take before using Toficalm 50 Tablet?

Patients with liver or kidney impairment may need dose adjustments and close monitoring while taking Toficalm 50 Tablet to avoid side effects.

Can Toficalm 50 Tablet be used for depression?

Toficalm 50 Tablet is not an antidepressant, but it may be prescribed alongside antidepressants in patients who have both anxiety and depression to improve overall mood and reduce tension.

Fact Box

Chemical Class

Benzodiazepines

Habit Forming

Yes

Therapeutic Class

NEURO CNS

Action Class

Benzodiazepines

References

User feedback

Patients taking Toficalm 50 Tablet

Twice A Day

49%

Once A Day

45%

Thrice A Day

Alternate Day

What are you using Toficalm Tablet for?

Depression

70%

Others

30%

How much was the improvement?

Average

58%

Excellent

30%

Poor

12%

What were the side-effects while using Toficalm 50 Tablet?

No Side Effect

65%

Loss of appetite

12%

Constipation

12%

Headache

Nausea

How do you take Toficalm Tablet?

With or without food

75%

With food

25%

Please rate Toficalm 50 Tablet on price

Average

57%

Expensive

35%

Not Expensive

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Sun Pharmaceutical Industries Ltd
Address: Khasra No. 1335-1340,Near EPIP- I, Vill - Bhatoli Kalan ,Baddi, Solan, Himachal Pradesh, 173205 || Plot no 107/108,Namli block , Ranipool, East Sikkim 737135

Vendor Details

Country of origin: India

Lab tests offered by us

Why we need a prescription?

Provide right medicines

Prescriptions are complex documents. We proof read and recheck at various steps to provide you the right medication in the correct form and dose

In accordance with the law

Most medicines cannot be sold without a valid prescription, as per the Drugs and Cosmetics Act, 1940 and Rules, 1945

Toficalm 50 Tablet

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General Information

Contains

Marketer

Storage

Product introduction

Uses of Toficalm Tablet

Benefits of Toficalm Tablet

Side effects of Toficalm Tablet

How to use Toficalm Tablet

How Toficalm Tablet works

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Tramadol (Injection Route)

Clozapine (Oral Route)

Tramadol (Oral Route)

Morphine (Oral Route)

Sirolimus (Injection Route)

Frequently asked questions

What is Toficalm 50 Tablet used for?

How does Toficalm 50 Tablet work for anxiety?

Can Toficalm 50 Tablet cause dependence or withdrawal symptoms?

Who should not take Toficalm 50 Tablet?

Can Toficalm 50 Tablet be taken with alcohol?

Does Toficalm 50 Tablet interact with other medicines?

Is Toficalm 50 Tablet safe for elderly patients?

Can Toficalm 50 Tablet be used in patients with epilepsy?

What precautions should people with liver or kidney problems take before using Toficalm 50 Tablet?

Can Toficalm 50 Tablet be used for depression?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

References

User feedback

Patients taking Toficalm 50 Tablet

What are you using Toficalm Tablet for?

How much was the improvement?

What were the side-effects while using Toficalm 50 Tablet?

How do you take Toficalm Tablet?

Please rate Toficalm 50 Tablet on price

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

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