Sevolex 400 Tablet

Sevelamer (400mg)

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Sevolex 400 Tablet is used to treat increased phosphate levels in the blood. It is used in patients who are on dialysis due to severe kidney disease. It inhibits the absorption of phosphate from the intestine and lowers the phosphate levels in the blood.

Written By Dr. Subita Alagh, BDS,
Reviewed By Dr. Sachin Gupta, MD Pharmacology, MBBS,
Last updated on 05 Sep 2026 | 01:02 AM (IST)

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General Information

Contains

Sevelamer (400mg)

Marketer

NUORIK HEALTHCARE PVT. LTD.

Storage

Store below 25°C

The content is shown in English

Product introduction

Sevolex 400 Tablet should be taken with food. Take it in the dose and duration as advised by your doctor. Take it regularly and at a fixed time each day to get the maximum benefit of the medicine.

Sevolex 400 Tablet may cause side effects such as nausea, vomiting, abdominal pain, constipation, and diarrhea. You may also develop low levels of calcium, folic acid, and vitamins A, D, E, and K in your blood. Take necessary supplements as advised by your doctor.

Uses of Sevolex Tablet

High phosphate levels in blood

Benefits of Sevolex Tablet

High phosphate levels in blood
Sevolex 400 Tablet is used to manage high phosphate levels in the blood, especially in people with chronic kidney disease on dialysis. It helps control phosphate buildup, which supports healthy bones and prevents problems like bone pain, itching, and complications related to the heart and blood vessels.

Side effects of Sevolex Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Sevolex

Diarrhea
Nausea
Vomiting
Indigestion
Gastrointestinal disorder

How to use Sevolex Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Sevolex 400 Tablet should be taken with or after food.

How Sevolex Tablet works

Sevolex 400 Tablet inhibits the absorption of phosphate from the intestine and lower the phosphate levels in the blood.

All substitutes for Sevolex 400 Tablet

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

Sevolex 400 Tablet is used to control blood phosphate level in patients that are on dialysis treatment.
You must take it with food and stick to the diet prescribed by your doctor.
You may develop low levels of calcium, folic acid, and vitamins A,D,E, and K in your blood. Your doctor may prescribe supplements, if necessary.
Avoid taking any other medicine 1 hour before or 3 hours after taking Sevolex 400 Tablet.
Inform your doctor if you have nausea, vomiting, constipation, pain in the abdomen, or if you have undergone any major stomach surgery.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Sevolex 400 Tablet. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

Sevolex 400 Tablet is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.

Breast feeding

CONSULT YOUR DOCTOR

Sevolex 400 Tablet may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.

Driving

SAFE

Sevolex 400 Tablet does not usually affect your ability to drive.

Kidney

CONSULT YOUR DOCTOR

There is limited data available on the use of Sevolex 400 Tablet in patients with kidney disease. Please consult your doctor.

Liver

SAFE IF PRESCRIBED

Sevolex 400 Tablet is probably safe to use in patients with liver disease. Limited data suggest dose adjustment may not be needed.

Interaction with drugs

Taking Sevolex with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Moderate

Ciprofloxacin (Oral Route)

To take Ciprofloxacin, ensure a gap of at least 1 hour before and 6 hours after taking Sevelamer. Sevelamer may reduce blood levels of Ciprofloxacin.

Moderate

Amiodarone (Oral Route)

To take Amiodarone, ensure a gap of at least 1 hour before or 3 hours after taking Sevelamer. Your doctor may monitor your treatment and adjust the doses as per the observations.

Moderate

Carbamazepine (Oral Route)

To take Carbamazepine, ensure a gap of at least 1 hour before or 3 hours after taking Sevelamer. Your doctor may monitor your treatment and adjust the doses as per the observations.

Moderate

Dexlansoprazole (Oral Route)

If concurrent use is essential, your doctor may monitor your potassium levels along with your overall treatment and adjust the doses as per the observations.

Moderate

Diltiazem (Oral Route)

To take Diltiazem, ensure a gap of at least 1 hour before or 3 hours after taking Sevelamer. Your doctor may monitor your treatment and adjust the doses as per the observations.

Frequently asked questions

Is Sevolex 400 Tablet taken with food?

Yes, Sevolex 400 Tablet can be taken with food. It is recommended to take 1-2 tablets (based on individual needs) thrice daily. It is important to take it with meals because Sevolex 400 Tablet works by binding to phosphate from food. Take it exactly as advised by your doctor.

Can Sevolex 400 Tablet be crushed?

No, you should not crush, chew, or break Sevolex 400 Tablet into pieces. You should swallow it as a whole with water.

Why is it important for me to take Sevolex 400 Tablet?

It is important to take Sevolex 400 Tablet as patients undergoing dialysis cannot control the phosphate levels in their blood, especially after a meal. When the level of phosphate exceeds above the range in the blood, it may cause problems such as itchy skin, red eyes, high blood pressure, bone pain, and also increase the risk of fractures. These increased serum phosphate levels are reduced by Sevolex 400 Tablet, as it binds phosphate from food in the digestive tract.

Does Sevolex 400 Tablet cause constipation?

A common side effect of Sevolex 400 Tablet is constipation, though it does not occur in everyone. The other common side effects of the stomach and intestine include diarrhea, indigestion, flatulence, and pain in the abdomen. Immediately consult your doctor if these side effects become severe and disturb you.

Who should not take Sevolex 400 Tablet?

Patients who are allergic to Sevolex 400 Tablet and who have low levels of phosphate in blood should avoid taking Sevolex 400 Tablet. Additionally, patients having intestinal obstruction should also avoid using Sevolex 400 Tablet.

Can I take ciprofloxacin while I am taking Sevolex 400 Tablet?

Ciprofloxacin may interfere with the working of Sevolex 400 Tablet and therefore it should not be taken at the same time as Sevolex 400 Tablet. However, if taken together then a gap of at least 2 hours before or 6 hours after taking Sevolex 400 Tablet should be maintained.

How long do I need to take Sevolex 400 Tablet?

Continue taking Sevolex 400 Tablet as long as recommended by your doctor. Sevolex 400 Tablet lowers your dietary phosphate levels but does not cure your disease. Hence, you may have to take it lifelong, as stopping Sevolex 400 Tablet may increase your phosphate levels.

Do I need to have any tests while taking Sevolex 400 Tablet?

Yes, serum phosphate levels should be monitored regularly while you are taking Sevolex 400 Tablet. Also, the use of Sevolex 400 Tablet may decrease the levels of vitamin D, A, E, K, and folic acid and hence the levels need to be monitored during the treatment.

Fact Box

Chemical Class

Epoxides

Habit Forming

Therapeutic Class

BLOOD RELATED

Action Class

Phosphorus Binders

Related lab tests

Calcium

Phosphorus, Serum

Phosphorus, Urine

References

Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. p. 1259.
Sevelamer hydrochloride. Guildford, Surrey: SANOFI; 2000 [revised 20 Dec. 2018]. [Accessed 30 Jan. 2019] (online) Available from:
Sevelamer. Cambridge, USA: Genzyme Corporation; 1998. [Accessed 6 Apr. 2019] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 6 Apr. 2019] (online) Available from:
Sevelamer Carbonate [Product Information]. Ahmedabad, Gujarat: La Renon. [Accessed 06 Aug. 2023]. (online) Available from:
National Center for Biotechnology Information. PubChem Compound Summary for , Sevelamer. [Accessed 06 Aug. 2023]. (online) Available from:

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Manufacturer details

Name: A)Vrindavan Global
Address: A)Plot No. 23-B & C, Ind. Area Lodhimajra, Baddi, Distt. Solan (H.P.) 173205

Marketer details

Name: NUORIK HEALTHCARE PVT. LTD.
Address: A23/58, Gulab Bagh, Uttam Nagar, New Delhi - 110059

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Sevolex 400 Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

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Blood Related

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Sevolex 400 Tablet

Sevolex 400 Tablet

Payment, Returns & Expiry

Cash on delivery available

7 day free return

Product expires after Dec, 2026

Price Info

Save more with additional offers

General Information

Contains

Marketer

Storage

Product introduction

Uses of Sevolex Tablet

Benefits of Sevolex Tablet

Side effects of Sevolex Tablet

How to use Sevolex Tablet

How Sevolex Tablet works

All substitutes for Sevolex 400 Tablet

Revlamer 400 Tablet

Sevcar 400 Tablet

Acutrol C 400 Tablet

Acutrol 400 Tablet

Phoscut 400 Tablet

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Ciprofloxacin (Oral Route)

Amiodarone (Oral Route)

Carbamazepine (Oral Route)

Dexlansoprazole (Oral Route)

Diltiazem (Oral Route)

Frequently asked questions

Is Sevolex 400 Tablet taken with food?

Can Sevolex 400 Tablet be crushed?

Why is it important for me to take Sevolex 400 Tablet?

Does Sevolex 400 Tablet cause constipation?

Who should not take Sevolex 400 Tablet?

Can I take ciprofloxacin while I am taking Sevolex 400 Tablet?

How long do I need to take Sevolex 400 Tablet?

Do I need to have any tests while taking Sevolex 400 Tablet?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

Related lab tests

Calcium

Phosphorus, Serum

Phosphorus, Urine

References

Want to know more

Have issue with the content

Disclaimer

Manufacturer details

Marketer details

Vendor Details

In case of any issues, contact us

Lab tests offered by us

Related/Popular tests